TMEM115 - transmembrane protein 115 Gene

Also Known as PL6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11070

About TMEM115

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:50,354,750-50,359,521 (from NCBI)

This gene has 1 transcript (splice variant) and 203 orthologues. Ubiquitous expression in placenta (RPKM 15.3), kidney (RPKM 14.6) and 25 other tissues.

Summary

Enables identical protein binding activity. Involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in Golgi cisterna membrane and nucleus. Colocalizes with Golgi transport complex. [provided by Alliance of Genome Resources, Apr 2022]

TMEM115 Products (1)

mRNA Protein Name
NM_007024.5 NP_008955.1 transmembrane protein 115

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IDA
IDA: Inferred from direct assay
24806965 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24806965 GOA
Biological Process GO Annotation Evidence References Source
involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
IMP: Inferred from mutant phenotype
24806965 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
17973242 GOA
located in Golgi cisterna membrane IDA
IDA: Inferred from direct assay
24806965 GOA
part of Golgi transport complex IDA
IDA: Inferred from direct assay
24806965 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17973242 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM115 Protein Structure

DUF1751

DUF1751: Eukaryotic integral membrane protein (DUF1751) (49 - 151)

  • 0
  • 100
  • 200
  • 300
  • 351 a.a.
Protein Preferred Names Protein Names

transmembrane protein 115

  • PP6

TMEM115 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TMEM115 Q12893 TMED8 Homo sapiens Q6PL24
Validated Y2H
32296183
Intra
TMEM115 Q12893 HTATIP2 Homo sapiens Q9BUP3-3
Validated Y2H
32296183
Intra
TMEM115 Q12893 TLCD4 Homo sapiens Q96MV1
Y2H Array
32296183
Intra
TMEM115 Q12893 TLCD4 Homo sapiens Q96MV1
Y2H Prey Pooling
32296183
Intra
TMEM115 Q12893 TLCD4 Homo sapiens Q96MV1
Validated Y2H
32296183
Intra
TMEM115 Q12893 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
TMEM115 Q12893 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra
TMEM115 Q12893 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
TMEM115 Q12893 ASPG Homo sapiens Q86U10
Y2H Prey Pooling
32296183
Intra
TMEM115 Q12893 ASPG Homo sapiens Q86U10
Validated Y2H
32296183
Intra
TMEM115 Q12893 ASPG Homo sapiens Q86U10
Y2H Array
32296183
Intra
TMEM115 Q12893 LAMP2 Homo sapiens P13473-2
Y2H Pooling
32814053
Intra
TMEM115 Q12893 LAMP2 Homo sapiens P13473-2
Validated Y2H
32814053
Intra
TMEM115 Q12893 LAMP2 Homo sapiens P13473-2
Y2H Array
32814053
Intra
TMEM115 Q12893 SH3GLB1 Homo sapiens Q9Y371
Validated Y2H
32814053
Intra
TMEM115 Q12893 SH3GLB1 Homo sapiens Q9Y371
Y2H Array
32814053
Intra
TMEM115 Q12893 SH3GLB1 Homo sapiens Q9Y371
Y2H Pooling
32814053
Intra
TMEM115 Q12893 MANBAL Homo sapiens Q9NQG1
Y2H Array
32296183
Intra
TMEM115 Q12893 MANBAL Homo sapiens Q9NQG1
Y2H Prey Pooling
32296183
Intra
TMEM115 Q12893 MANBAL Homo sapiens Q9NQG1
Validated Y2H
32296183
Intra
TMEM115 Q12893 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
TMEM115 Q12893 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
TMEM115 Q12893 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
TMEM115 Q12893 RABAC1 Homo sapiens Q9UI14
Validated Y2H
32296183
Intra
TMEM115 Q12893 SYNE4 Homo sapiens Q8N205
Validated Y2H
25416956
Intra
TMEM115 Q12893 SYNE4 Homo sapiens Q8N205
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Short-Rib Thoracic Dysplasia 2 With Or Without Polydactyly

  • Asphyxiating Thoracic Dystrophy 2

  • SRTD2

  • Atd2

  • Jatd

  • Jeune Asphyxiating Thoracic Dystrophy

  • Jeune Syndrome 2
Louse-Borne Relapsing Fever

  • Relapsing Fever, Louse-Borne

  • Relapsing Fever Due To Borrelia Recurrentis
Tick-Borne Relapsing Fever

  • Relapsing Fever, Tick-Borne

  • Relapsing Fever Due To Any Borrelia Species Other Than Borrelia Recurrentis

  • African Tick-Borne Fever
Uterus Carcinoma In Situ
Cervix Uteri Carcinoma In Situ

  • Carcinoma In Situ Of Cervix

  • Carcinoma In Situ Of Uterine Cervix

  • Cervical Intraepithelial Neoplasia

  • Carcinoma Of Cervix Stage 0

  • Cervical Intraepithelial Neoplasia Grade Iii With Severe Dysplasia

  • Cervix Ca In Situ

  • Cin Iii

  • Cin Iii - Carcinoma In Situ Of Cervix

  • Cin Iii - Severe Dyskaryosis

  • Severe Dysplasia Of Cervix

  • Severe Dysplasia Of The Cervix Uteri

  • Squamous Intraepithelial Neoplasia, Grade Iii

  • Cervix Intraepithelial Neoplasia Grade 3 Ajcc V7
Gaucher Disease, Type Iiic

  • Gaucher Disease-Ophthalmoplegia-Cardiovascular Calcification Syndrome

  • Gaucher-Like Disease

  • GD3C

  • Gaucher'S Disease Type Iiic

  • Cardiovascular Gaucher Disease

  • Gaucher Disease Type 3c

  • Gaucher Disease 3c

  • Pseudo-Gaucher Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14652 TMEM115 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TMEM115 VGNC VGNC:47452
Felis catus TMEM115 VGNC VGNC:66261
Bos taurus TMEM115 VGNC VGNC:35952
Rattus norvegicus TMEM115 RGD RGD:1310540
Macaca mulatta TMEM115 VGNC VGNC:110327
Mus musculus TMEM115 MGD MGI:1930765
Others TMEM115 NCBI