TMEM115 - transmembrane protein 115 Gene

Homo sapiens

Also known as PL6

Gene ID: 11070 | Gene type: protein coding

About TMEM115

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:50,354,750-50,359,521 (from NCBI)

This gene has 1 transcript (splice variant) and 203 orthologues. Ubiquitous expression in placenta (RPKM 15.3), kidney (RPKM 14.6) and 25 other tissues.

Summary

Enables identical protein binding activity. Involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in Golgi cisterna membrane and nucleus. Colocalizes with Golgi transport complex. [provided by Alliance of Genome Resources, Apr 2022]

TMEM115 Products(1)

mRNA	Protein	Name
NM_007024.5	NP_008955.1	transmembrane protein 115

TMEM115 Protein Structure

DUF1751

0
100
200
300
351 a.a.

Protein Preferred Names

Protein Names

transmembrane protein 115

PP6

Related Diseases

Diseases

Alias

Short-Rib Thoracic Dysplasia 2 With Or Without Polydactyly

Asphyxiating Thoracic Dystrophy 2	SRTD2
Atd2	Jatd
Jeune Asphyxiating Thoracic Dystrophy	Jeune Syndrome 2

Louse-Borne Relapsing Fever

Relapsing Fever, Louse-Borne

Relapsing Fever Due To Borrelia Recurrentis

Tick-Borne Relapsing Fever

Relapsing Fever, Tick-Borne	Relapsing Fever Due To Any Borrelia Species Other Than Borrelia Recurrentis
African Tick-Borne Fever

Uterus Carcinoma In Situ

Cervix Uteri Carcinoma In Situ

Carcinoma In Situ Of Cervix	Carcinoma In Situ Of Uterine Cervix
Cervical Intraepithelial Neoplasia	Carcinoma Of Cervix Stage 0
Cervical Intraepithelial Neoplasia Grade Iii With Severe Dysplasia	Cervix Ca In Situ
Cin Iii	Cin Iii - Carcinoma In Situ Of Cervix
Cin Iii - Severe Dyskaryosis	Severe Dysplasia Of Cervix
Severe Dysplasia Of The Cervix Uteri	Squamous Intraepithelial Neoplasia, Grade Iii
Cervix Intraepithelial Neoplasia Grade 3 Ajcc V7

Gaucher Disease, Type Iiic

Gaucher Disease-Ophthalmoplegia-Cardiovascular Calcification Syndrome	Gaucher-Like Disease
GD3C	Gaucher'S Disease Type Iiic
Cardiovascular Gaucher Disease	Gaucher Disease Type 3c
Gaucher Disease 3c	Pseudo-Gaucher Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14652	TMEM115 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TMEM115	VGNC	VGNC:47452
Felis catus	TMEM115	VGNC	VGNC:66261
Bos taurus	TMEM115	VGNC	VGNC:35952
Rattus norvegicus	TMEM115	RGD	RGD:1310540
Macaca mulatta	TMEM115	VGNC	VGNC:110327
Mus musculus	TMEM115	MGD	MGI:1930765

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