LYPLA2 - lysophospholipase 2 Gene

Also Known as APT2; APT-2; DJ886K2.4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11313

About LYPLA2

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:23,791,145-23,795,539 (from NCBI)

This gene has 10 transcripts (splice variants), 209 orthologues and 2 paralogues. Ubiquitous expression in placenta (RPKM 17.1), duodenum (RPKM 15.8) and 25 other tissues.

Summary

Lysophospholipases are Enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. [provided by RefSeq, Jul 2008]

LYPLA2 Products (1)

mRNA Protein Name
NM_007260.3 NP_009191.1 acyl-protein thioesterase 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables lysophospholipase activity IDA
IDA: Inferred from direct assay
25301951 GOA
enables palmitoyl-(protein) hydrolase activity IDA
IDA: Inferred from direct assay
28826475 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in acylglycerol catabolic process IDA
IDA: Inferred from direct assay
25301951 GOA
involved in prostaglandin catabolic process IDA
IDA: Inferred from direct assay
25301951 GOA
involved in protein depalmitoylation IDA
IDA: Inferred from direct assay
28826475 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
25468996 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LYPLA2 Protein Structure

Abhydrolase_2

Abhydrolase_2: Phospholipase/Carboxylesterase (13 - 227)

  • 0
  • 100
  • 200
  • 231 a.a.
Protein Preferred Names Protein Names

acyl-protein thioesterase 2

  • LPL-II

LYPLA2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LYPLA2 O95372 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
LYPLA2 O95372 INCA1 Homo sapiens Q0VD86
Validated Y2H
32296183
Intra
LYPLA2 O95372 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LYPLA2 Proteins

Cat. No. Product Name Accession Purity
HY-P70221 Acyl-protein thioesterase 2/LYPLA2 Protein, Human (His) O95372 (M1-V231) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Hypotonia-Cystinuria Syndrome

  • Cystinuria With Mitochondrial Disease

  • 2p21 Microdeletion Syndrome

  • HCS

  • Homozygous 2p16 Deletion Syndrome, Formerly

  • 2p21 Deletion Syndrome

  • Del(2)(P21)

  • Monosomy 2p21

  • Atypical Hypotonia-Cystinuria Syndrome

  • Atypical Hcs
Neuronal Ceroid Lipofuscinosis

  • Hereditary Ceroid Lipofuscinosis

  • Batten Disease

  • Ncl

  • Neuronal Ceroid-Lipofuscinoses

  • Lipofuscinosis, Ceroid, Neuronal

  • Juvenile Neuronal Ceroid Lipofuscinosis

  • Cerebromacular Dystrophy

  • Cerebromacular Degeneration

  • Ceroid-Lipofuscinosis

  • Ncl - [Neuronal Ceroid Lipofuscinosis]

  • Amaurotic Familial Idiocy

  • Amaurotic Idiocy

  • Amaurotic Idiot

  • Neuronal Lipofuscinosis

  • Pigmentary Retinal Lipoid Neuronal Heredodegeneration
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100736 ML348 Inhibitor 99.97% Unkown
HY-100737 ML349 Inhibitor 99.47% Unkown
HY-128035 ML-211 Inhibitor 99.42% Unkown
HY-129121 ML-​226 Inhibitor 98.76% Unkown
HY-120126 ML378 Inhibitor / Unkown
HY-RS07922 LYPLA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18712 Lypla2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25199 Lypla2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus LYPLA2 MGD MGI:1347000
Macaca mulatta LYPLA2 VGNC VGNC:74465
Canis familiaris LYPLA2 VGNC VGNC:42891
Felis catus LYPLA2 VGNC VGNC:68112
Bos taurus LYPLA2 VGNC VGNC:31106
Rattus norvegicus LYPLA2 RGD RGD:620210
Others LYPLA2 NCBI