Ace - angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 Gene

Also Known as CD143

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11421

About Ace

Chromosome 11: 105,858,771-105,880,790 forward strand.GRCm39:CM001004.3

This gene has 4 transcripts (splice variants), 94 orthologues, 2 paralogues and is associated with 88 phenotypes. Biased expression in lung adult (RPKM 34.6), duodenum adult (RPKM 225.6) and 6 other tissues.

Summary

Enables metallopeptidase activity and peptidyl-dipeptidase activity. Involved in several processes, including cell proliferation in bone marrow; positive regulation of protein modification process; and regulation of gene expression. Acts upstream of or within several processes, including heart contraction; neutrophil mediated immunity; and positive regulation of systemic arterial blood pressure. Located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system Cancer (multiple); heart valve disease (multiple); and lung disease (multiple). Orthologous to human ACE (angiotensin I converting enzyme). [provided by Alliance of Genome Resources, Apr 2022]

Ace Products (3)

mRNA Protein Name
NM_009598.3 NP_033728.1 angiotensin-converting enzyme isoform 2 precursor
NM_207624.6 NP_997507.1 angiotensin-converting enzyme isoform 1 precursor
NM_001281819.2 NP_001268748.1 angiotensin-converting enzyme isoform 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables metallopeptidase activity IDA
IDA: Inferred from direct assay
11303049 MGI
enables peptidase activity IMP
IMP: Inferred from mutant phenotype
9231832 MGI
enables peptidyl-dipeptidase activity IDA
IDA: Inferred from direct assay
11303049 MGI
enables peptidyl-dipeptidase activity IMP
IMP: Inferred from mutant phenotype
16270063 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23055941 MGI
Biological Process GO Annotation Evidence References Source
involved in angiotensin maturation IDA
IDA: Inferred from direct assay
11303049 MGI
involved in angiotensin maturation IMP
IMP: Inferred from mutant phenotype
14757757 MGI
involved in angiotensin-activated signaling pathway IMP
IMP: Inferred from mutant phenotype
25017399 MGI
involved in cell proliferation in bone marrow IMP
IMP: Inferred from mutant phenotype
20116413 MGI
acts upstream of or within heart contraction IMP
IMP: Inferred from mutant phenotype
16585392 MGI
involved in hormone catabolic process IDA
IDA: Inferred from direct assay
11303049 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
17135368 MGI
involved in kidney development IMP
IMP: Inferred from mutant phenotype
11723129 MGI
involved in male gonad development IMP
IMP: Inferred from mutant phenotype
11723129 MGI
involved in negative regulation of gap junction assembly IMP
IMP: Inferred from mutant phenotype
25017399 MGI
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
25017399 MGI
acts upstream of or within neutrophil mediated immunity IMP
IMP: Inferred from mutant phenotype
17082641 MGI
involved in positive regulation of peptidyl-cysteine S-nitrosylation IMP
IMP: Inferred from mutant phenotype
25017399 MGI
acts upstream of or within positive regulation of systemic arterial blood pressure IMP
IMP: Inferred from mutant phenotype
9231832 MGI
involved in post-transcriptional regulation of gene expression IMP
IMP: Inferred from mutant phenotype
25017399 MGI
involved in regulation of blood pressure IDA
IDA: Inferred from direct assay
11303049 MGI
involved in regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
11723129 MGI
involved in regulation of heart rate by cardiac conduction IMP
IMP: Inferred from mutant phenotype
25017399 MGI
involved in regulation of hematopoietic stem cell proliferation IMP
IMP: Inferred from mutant phenotype
20116413 MGI
involved in regulation of synaptic plasticity IDA
IDA: Inferred from direct assay
35201898 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
17135368 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
23535237 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
23535237 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ace Protein Structure

Peptidase_M2

Peptidase_M2: pfam01401 (44 - 627)

Peptidase_M2

Peptidase_M2: pfam01401 (648 - 1225)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1312 a.a.
Protein Preferred Names Protein Names

angiotensin-converting enzyme

  • dipeptidyl carboxypeptidase I

  • dipeptidyl peptidase

  • kininase II

Ace Antibodies

Cat. No. Product Name Application Reactivity
HY-P82349 ACE Antibody (YA2094) WB, IHC-P Mouse, Rat
HY-P82349A ACE Antibody (YA2094)(PBS only) WB, IHC-P Mouse, Rat

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0331 Enalapril Inhibitor 99.96% Yes
HY-B0331A Enalapril maleate Inhibitor 99.99% Yes
HY-B0331AR Enalapril maleate (Standard) Inhibitor 99.95% Unkown
HY-B1451 Imidapril hydrochloride Inhibitor 99.91% Yes
HY-B0331B Enalapril sodium Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-123381 Gemopatrilat Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-138113 Pyrrothiogatain Inhibitor 98.61% Unkown
HY-N0217 Benzoylaconine Modulator 99.92% Unkown
HY-N5063 Plantainoside D Inhibitor 99.15% Unkown
HY-B0331AS Enalapril-d5 maleate Inhibitor 99.01% Unkown
HY-P10601 αs1-CN f(143–149) Inhibitor / Unkown
HY-19200 RB-105 Inhibitor / Unkown
HY-P11464 SARS-CoV-2 Spike receptor binding domain, RBD (371-394) / Unkown
HY-P4281 Ovotransferrin (328-332) Inhibitor / Unkown
HY-182407 CV 5975 Inhibitor / Unkown
HY-182445 FPL 66564 Inhibitor / Unkown
HY-175325 SARS-CoV-2-IN-116 Inhibitor / Unkown
HY-B0331S1 Enalapril-d3 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ace NCBI NCBI:1636