Afp - alpha fetoprotein Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11576

Summary

Predicted to enable fatty acid binding activity and zinc ion binding activity. Acts upstream of or within SMAD protein signal transduction; ovulation from ovarian follicle; and progesterone metabolic process. Located in cytoplasm and extracellular space. Is expressed in several structures, including amniotic fluid; egg cylinder; gut; liver and biliary system; and metanephros. Human ortholog(s) of this gene implicated in hepatitis C. Orthologous to human AFP (alpha fetoprotein). [provided by Alliance of Genome Resources, Apr 2022]

Afp Products (1)

mRNA Protein Name
NM_007423.4 NP_031449.3 alpha-fetoprotein precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within apoptotic process IMP
IMP: Inferred from mutant phenotype
36301669 MGI
acts upstream of or within homeostasis of number of cells IMP
IMP: Inferred from mutant phenotype
36301669 MGI
acts upstream of or within immune response IMP
IMP: Inferred from mutant phenotype
36301669 MGI
acts upstream of or within ovulation from ovarian follicle IMP
IMP: Inferred from mutant phenotype
12297623 MGI
acts upstream of or within progesterone metabolic process IMP
IMP: Inferred from mutant phenotype
12297623 MGI
acts upstream of or within sexual reproduction IMP
IMP: Inferred from mutant phenotype
12297623 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
8607965 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
67170 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alpha-fetoprotein

  • alpha-1-fetoprotein

  • alpha-fetoglobulin

  • alpha-foetoprotein

Recombinant Afp Proteins

Cat. No. Product Name Accession Purity
HY-P7464 Alpha-Fetoprotein Protein, Mouse (HEK293, His) P02772 (K19-V605) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0600 Tafluprost Control 99.69% Yes
HY-B0601 Tafluprost acid 99.97% Unkown
HY-116733 Tafluprost ethyl ester Agonist / Unkown

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-16031B AFP464 dihydrochloride 99.45% Phase 2
HY-16031 AFP464 free base / Phase 2
HY-16031A AFP464 / Phase 2

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-103469 Peroxy Orange 1 99.20% Unkown
HY-175606 EVT0185 Inhibitor 99.39% Unkown
HY-160042 AFP aptamer sodium 94.04% Unkown
HY-105315 AFP-07 Agonist / Unkown
HY-129293 AFP-07 free acid Agonist / Unkown
HY-187304S [U-15N]-AFP / Unkown
HY-187307S [U-15N]-PIVKA-II / Unkown
HY-NP228 Alpha fetoprotein, human / Unkown
HY-RS00435 AFP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15031 TRIM26 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-129922 16(R)-AFP 07 free acid / Unkown
HY-160042A AFP aptamer sodium scrambled negative control / Unkown
HY-160042B FAM labled AFP aptamer sodium / Unkown
HY-160042C Cy3 labled AFP aptamer sodium / Unkown
HY-RS16874 Afp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23316 Afp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991858 Anti-AFP Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Afp NCBI NCBI:174