Vcp - valosin-containing protein Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116643

About Vcp

Primary_assembly 5: 57,210,168-57,229,571 reverse strand.mRatBN7.2:CM026978.1

This gene has 1 transcript (splice variant), 229 orthologues, 6 paralogues and is associated with 25 phenotypes. Biased expression in Heart (RPKM 1161.1), Muscle (RPKM 181.6) and 9 other tissues.

Summary

Enables ATP hydrolysis activity; adenyl ribonucleotide binding activity; and identical protein binding activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of ubiquitin-dependent protein catabolic process; and regulation of synapse organization. Located in cytosol and endoplasmic reticulum. Part of VCP-NPL4-UFD1 AAA ATPase complex and VCP-NSFL1C complex. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; Paget's disease of bone; amyotrophic lateral sclerosis type 14; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1; and inclusion body myositis. Orthologous to human VCP (valosin containing protein). [provided by Alliance of Genome Resources, Apr 2022]

Vcp Products (1)

mRNA Protein Name
NM_053864.2 NP_446316.1 transitional endoplasmic reticulum ATPase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ADP binding IMP
IMP: Inferred from mutant phenotype
18332143 RGD
enables ATP binding IDA
IDA: Inferred from direct assay
7806566 RGD
enables ATP binding IMP
IMP: Inferred from mutant phenotype
18332143 RGD
enables ATP hydrolysis activity IDA
IDA: Inferred from direct assay
7806566 RGD
enables ATP hydrolysis activity IMP
IMP: Inferred from mutant phenotype
18332143 RGD
enables identical protein binding IDA
IDA: Inferred from direct assay
7806566 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
7806566 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9214505 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
10811609 RGD
Biological Process GO Annotation Evidence References Source
involved in ERAD pathway IDA
IDA: Inferred from direct assay
12847084 RGD
involved in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
7806566 RGD
involved in positive regulation of ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
16103111 RGD
involved in regulation of synapse organization IDA
IDA: Inferred from direct assay
22105171 RGD
involved in regulation of synapse organization IMP
IMP: Inferred from mutant phenotype
22105171 RGD
involved in retrograde protein transport, ER to cytosol EXP
EXP: Inferred from Experiment
12847084 RGD
Cellular Component GO Annotation Evidence References Source
part of VCP-NPL4-UFD1 AAA ATPase complex EXP
EXP: Inferred from Experiment
22232657 RGD
part of VCP-NPL4-UFD1 AAA ATPase complex IDA
IDA: Inferred from direct assay
10811609 RGD
part of VCP-NSFL1C complex IPI
IPI: Inferred from physical interaction
9214505 RGD
located in cytosol IDA
IDA: Inferred from direct assay
9214505 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
22105171 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
22105171 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Vcp Protein Structure

CDC48

CDC48: cl36852 (24 - 763)

  • 0
  • 200
  • 400
  • 600
  • 806 a.a.
Protein Preferred Names Protein Names

transitional endoplasmic reticulum ATPase

  • 15S Mg(2+)-ATPase p97 subunit

  • TER ATPase

Vcp Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Vcp P46462 Nsfl1c Rattus norvegicus O35987
Anti Bait CoIP
9214505
Intra
Vcp P46462 Nsfl1c Rattus norvegicus O35987
GMS
9214505
Intra
Vcp P46462 Nsfl1c Rattus norvegicus O35987
GMS
10811609
Intra
Vcp P46462 Nsfl1c Rattus norvegicus O35987
Competition Binding
20691684
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-138233 KUS121 Modulator 99.76% Phase 2
HY-177414 BB-1701 Inhibitor 98.81% Phase 2
HY-12861 CB-5083 Inhibitor 99.90% Phase 1

Pre-clinical Phase

Bioactive Molecules (26)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15713 NMS-873 Inhibitor 99.92% Unkown
HY-123872 MSC1094308 Inhibitor 99.63% Unkown
HY-128870 Mal-PEG2-VCP-Eribulin 99.79% Unkown
HY-157508 VCP Activator 1 Activator 99.94% Unkown
HY-15714 NMS-859 Inhibitor 98.02% Unkown
HY-168323 UP163 Activator 98.08% Unkown
HY-168324 UP158 Activator 99.88% Unkown
HY-RS15621 VCP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-168325 UP12 Activator 97.69% Unkown
HY-124776 NPD8733 Inhibitor 99.92% Unkown
HY-130084 Mal-PEG2-VCP-NB 98.25% Unkown
HY-139606 VCP/p97 inhibitor-1 Inhibitor 98.64% Unkown
HY-RS15623 Vcp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-113608 VCP171 Modulator 99.18% Unkown
HY-128871 VCP-Eribulin / Unkown
HY-148122 NW 1028 Inhibitor / Unkown
HY-160981 Mal-PEG4-VCP-NB / Unkown
HY-160982 Mal-PEG3-VCP-NB / Unkown
HY-168007 NSC804515 Inhibitor / Unkown
HY-174847 VCP/p97 IN-2 Inhibitor / Unkown
HY-174984 VCP/p97 IN-3 / Unkown
HY-177549 Fmoc-PEG6-VCP-Eribulin / Unkown
HY-183257 ATI-1 / Unkown
HY-184291 VCP/p97 IN-4 / Unkown
HY-RS15622 Vcp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-118460 ACJI-99C Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vcp NCBI NCBI:7415