VCP - valosin containing protein Gene

Also Known as p97; TERA; CDC48; FTDALS6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7415

About VCP

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:35,056,064-35,072,625 (from NCBI)

This gene has 36 transcripts (splice variants), 229 orthologues, 5 paralogues and is associated with 12 phenotypes. Ubiquitous expression in appendix (RPKM 60.7), thyroid (RPKM 56.9) and 25 other tissues.

Summary

This gene encodes a member of the AAA ATPase family of proteins. The encoded protein plays a role in protein degradation, intracellular membrane fusion, DNA repair and replication, regulation of the cell cycle, and activation of the NF-kappa B pathway. This protein forms a homohexameric complex that interacts with a variety of cofactors and extracts ubiquitinated proteins from lipid membranes or protein complexes. Mutations in this gene cause IBMPFD (inclusion body myopathy with paget disease of bone and frontotemporal dementia), ALS (amyotrophic lateral sclerosis) and Charcot-Marie-Tooth disease in human patients. [provided by RefSeq, Aug 2017]

VCP Products (3)

mRNA	Protein	Name
NM_001354927.2	NP_001341856.1	transitional endoplasmic reticulum ATPase isoform 2
NM_007126.5	NP_009057.1	transitional endoplasmic reticulum ATPase isoform 1
NM_001354928.2	NP_001341857.1	transitional endoplasmic reticulum ATPase isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	24129571	GOA
enables ATP hydrolysis activity	IMP IMP: Inferred from mutant phenotype	23349634	GOA
enables BAT3 complex binding	IPI IPI: Inferred from physical interaction	21636303	GOA
enables K48-linked polyubiquitin modification-dependent protein binding	IDA IDA: Inferred from direct assay	37816088	GOA
enables deubiquitinase activator activity	IDA IDA: Inferred from direct assay	22970133	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	20512113	GOA
enables polyubiquitin modification-dependent protein binding	IDA IDA: Inferred from direct assay	11483959	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9452483	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	15362974	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	10364224	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	22590560	GOA
enables ubiquitin-like protein ligase binding	IPI IPI: Inferred from physical interaction	16186510	GOA
enables ubiquitin-modified protein reader activity	IDA IDA: Inferred from direct assay	29033132	GOA
enables ubiquitin-specific protease binding	IPI IPI: Inferred from physical interaction	22590560	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	16140914	GOA
involved in ERAD pathway	IDA IDA: Inferred from direct assay	17872946	GOA
involved in ERAD pathway	IMP IMP: Inferred from mutant phenotype	20104022	GOA
involved in NADH metabolic process	IMP IMP: Inferred from mutant phenotype	23498975	GOA
involved in autophagosome maturation	IMP IMP: Inferred from mutant phenotype	20104022	GOA
involved in autophagy	IMP IMP: Inferred from mutant phenotype	20104022	GOA
involved in cellular response to arsenite ion	IMP IMP: Inferred from mutant phenotype	29804830	GOA
involved in cellular response to heat	IMP IMP: Inferred from mutant phenotype	29804830	GOA
involved in cellular response to misfolded protein	IMP IMP: Inferred from mutant phenotype	24089527	GOA
involved in cytoplasm protein quality control	IDA IDA: Inferred from direct assay	29033132	GOA
involved in double-strand break repair	IDA IDA: Inferred from direct assay	10855792	GOA
involved in endoplasmic reticulum stress-induced pre-emptive quality control	IMP IMP: Inferred from mutant phenotype	26565908	GOA
involved in endosome to lysosome transport via multivesicular body sorting pathway	IMP IMP: Inferred from mutant phenotype	21822278	GOA
involved in flavin adenine dinucleotide catabolic process	IMP IMP: Inferred from mutant phenotype	23498975	GOA
involved in macroautophagy	IMP IMP: Inferred from mutant phenotype	27753622	GOA
involved in negative regulation of hippo signaling	IGI IGI: Inferred from genetic interaction	38710747	GOA
involved in negative regulation of protein localization to chromatin	IDA IDA: Inferred from direct assay	35013556	GOA
involved in negative regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	23747190	GOA
involved in positive regulation of ATP biosynthetic process	IMP IMP: Inferred from mutant phenotype	23498975	GOA
involved in positive regulation of Lys63-specific deubiquitinase activity	IDA IDA: Inferred from direct assay	22970133	GOA
involved in positive regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	28689657	GOA
involved in positive regulation of mitochondrial membrane potential	IMP IMP: Inferred from mutant phenotype	23498975	GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	37816088	GOA
involved in positive regulation of oxidative phosphorylation	IMP IMP: Inferred from mutant phenotype	23498975	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	9452483	GOA
involved in positive regulation of protein K63-linked deubiquitination	IDA IDA: Inferred from direct assay	22970133	GOA
involved in positive regulation of protein catabolic process	IDA IDA: Inferred from direct assay	11483959	GOA
involved in positive regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	18775313	GOA
involved in proteasomal protein catabolic process	IMP IMP: Inferred from mutant phenotype	26565908	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	31387940	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	20104022	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	22120668	GOA
involved in protein-DNA covalent cross-linking repair	IDA IDA: Inferred from direct assay	32152270	GOA
involved in regulation of aerobic respiration	IMP IMP: Inferred from mutant phenotype	23498975	GOA
involved in regulation of protein localization to chromatin	IDA IDA: Inferred from direct assay	32152270	GOA
involved in retrograde protein transport, ER to cytosol	IDA IDA: Inferred from direct assay	15215856	GOA
involved in retrograde protein transport, ER to cytosol	IMP IMP: Inferred from mutant phenotype	25660456	GOA
involved in stress granule disassembly	IDA IDA: Inferred from direct assay	36692217	GOA
involved in stress granule disassembly	IMP IMP: Inferred from mutant phenotype	29804830	GOA
involved in translesion synthesis	IMP IMP: Inferred from mutant phenotype	23042605	GOA
involved in viral genome replication	IMP IMP: Inferred from mutant phenotype	22379090	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Derlin-1 retrotranslocation complex	IDA IDA: Inferred from direct assay	15215856	GOA
part of VCP-NPL4-UFD1 AAA ATPase complex	IPI IPI: Inferred from physical interaction	20414249	GOA
part of VCP-NSFL1C complex	IPI IPI: Inferred from physical interaction	21645854	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	27753622	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	29804830	GOA
located in cytosol	IDA IDA: Inferred from direct assay	10855792	GOA
is active in cytosol	IMP IMP: Inferred from mutant phenotype	38710747	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	15215856	GOA
is active in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	24129571	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	17872946	GOA
located in lipid droplet	IDA IDA: Inferred from direct assay	23297223	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10855792	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16275660	GOA
part of proteasome complex	IDA IDA: Inferred from direct assay	9452483	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	21822278	GOA
located in site of double-strand break	IDA IDA: Inferred from direct assay	22120668	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VCP Protein Structure

CDC48_N

CDC48_2

AAA

Vps4_C

0
200
400
600
806 a.a.

Protein Preferred Names	Protein Names
transitional endoplasmic reticulum ATPase	15S Mg(2+)-ATPase p97 subunit TER ATPase

VCP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	VCP	P55072	ATG5	Homo sapiens	A9UGY9	Y2H Prey Pooling	25416956
Intra	VCP	P55072	VCF1	Homo sapiens	Q969W3	Validated Y2H	32296183
Intra	VCP	P55072	VCF1	Homo sapiens	Q969W3	Y2H Prey Pooling	25416956
Intra	VCP	P55072	VCF1	Homo sapiens	Q969W3	Anti Tag CoIP	33961781
Intra	VCP	P55072	AMFR	Homo sapiens	Q9UKV5	Filter Binding	16275660
Intra	VCP	P55072	AMFR	Homo sapiens	Q9UKV5	Pull Down	26712280
Intra	VCP	P55072	AMFR	Homo sapiens	Q9UKV5	Pull Down	16275660
Intra	VCP	P55072	AMFR	Homo sapiens	Q9UKV5	IF	16275660
Intra	VCP	P55072	PTPN3	Homo sapiens	P26045	Anti Tag CoIP	10364224
Intra	VCP	P55072	FAF2	Homo sapiens	Q96CS3	Anti Tag CoIP	35271311
Intra	VCP	P55072	FAF2	Homo sapiens	Q96CS3	BRET	29997244
Intra	VCP	P55072	UBXN1	Homo sapiens	Q04323	Y2H Prey Pooling	25416956
Intra	VCP	P55072	METTL17	Homo sapiens	Q9H7H0-2	Validated Y2H	32296183
Intra	VCP	P55072	FCHSD2	Homo sapiens	O94868	Y2H	18654987
Cross	VCP	P55072	Cul1	Mus musculus	Q9WTX6	Anti Tag CoIP	22466964
Intra	VCP	P55072	UBXN2B	Homo sapiens	Q14CS0	Anti Tag CoIP	35271311
Intra	VCP	P55072	UBXN2B	Homo sapiens	Q14CS0	Validated Y2H	32296183
Intra	VCP	P55072	UBXN2B	Homo sapiens	Q14CS0	BRET	29997244
Intra	VCP	P55072	UBXN2B	Homo sapiens	Q14CS0	Y2H Prey Pooling	25416956
Intra	VCP	P55072	UBXN7	Homo sapiens	O94888	Anti Tag CoIP	18775313
Intra	VCP	P55072	UBXN2A	Homo sapiens	P68543	Y2H	21900206
Intra	VCP	P55072	UBXN2A	Homo sapiens	P68543	Validated Y2H	32296183
Intra	VCP	P55072	UBXN2A	Homo sapiens	P68543	Anti Tag CoIP	35271311
Intra	VCP	P55072	UBXN2A	Homo sapiens	P68543	BRET	29997244
Intra	VCP	P55072	ASPSCR1	Homo sapiens	Q9BZE9	Validated Y2H	25416956
Intra	VCP	P55072	ASPSCR1	Homo sapiens	Q9BZE9	Y2H Array	25416956
Intra	VCP	P55072	ASPSCR1	Homo sapiens	Q9BZE9	Anti Tag CoIP	26496610
Intra	VCP	P55072	ASPSCR1	Homo sapiens	Q9BZE9	Y2H	21900206
Intra	VCP	P55072	ASPSCR1	Homo sapiens	Q9BZE9	BRET	29997244
Intra	VCP	P55072	UBXN8	Homo sapiens	O00124	Anti Tag CoIP	35271311
Intra	VCP	P55072	UBXN8	Homo sapiens	O00124	Lumier	29997244
Intra	VCP	P55072	UBXN8	Homo sapiens	O00124	BRET	29997244
Intra	VCP	P55072	UBXN6	Homo sapiens	Q9BZV1	Anti Tag CoIP	35271311
Intra	VCP	P55072	UBXN6	Homo sapiens	Q9BZV1	Lumier	29997244
Intra	VCP	P55072	UBXN6	Homo sapiens	Q9BZV1	Anti Tag CoIP	18775313
Intra	VCP	P55072	UBXN6	Homo sapiens	Q9BZV1	Y2H	18656546
Intra	VCP	P55072	UBXN6	Homo sapiens	Q9BZV1	BRET	29997244
Intra	VCP	P55072	UBXN6	Homo sapiens	Q9BZV1	GMS	18656546
Intra	VCP	P55072	UBXN10	Homo sapiens	Q96LJ8	BRET	29997244
Intra	VCP	P55072	PLAA	Homo sapiens	Q9Y263	Validated Y2H	32296183
Intra	VCP	P55072	PLAA	Homo sapiens	Q9Y263	Anti Tag CoIP	35271311
Intra	VCP	P55072	PLAA	Homo sapiens	Q9Y263	Validated Y2H	25416956
Intra	VCP	P55072	UFD1	Homo sapiens	Q92890	X-Ray Diffraction	26712280
Intra	VCP	P55072	UFD1	Homo sapiens	Q92890	Anti Tag CoIP	18775313
Intra	VCP	P55072	UFD1	Homo sapiens	Q92890	Pull Down	26712280
Intra	VCP	P55072	UFD1	Homo sapiens	Q92890	Anti Tag CoIP	20414249
Intra	VCP	P55072	UFD1	Homo sapiens	Q92890	Anti Tag CoIP	35271311
Intra	VCP	P55072	NPLOC4	Homo sapiens	Q8TAT6	Anti Tag CoIP	35271311
Intra	VCP	P55072	NPLOC4	Homo sapiens	Q8TAT6	Anti Tag CoIP	18775313
Intra	VCP	P55072	NPLOC4	Homo sapiens	Q8TAT6	Anti Tag CoIP	20414249
Intra	VCP	P55072	NPLOC4	Homo sapiens	Q8TAT6	Anti Bait CoIP	20414249
Intra	VCP	P55072	NPLOC4	Homo sapiens	Q8TAT6	Anti Tag CoIP	33961781
Intra	VCP	P55072	RNF125	Homo sapiens	Q96EQ8	Pull Down	26471729
Intra	VCP	P55072	YOD1	Homo sapiens	Q5VVQ6	Validated Y2H	32296183
Intra	VCP	P55072	XAF1	Homo sapiens	Q6GPH4	Validated Y2H	32296183
Intra	VCP	P55072	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	VCP	P55072	YWHAZ	Homo sapiens	P63104	Y2H Array	21988832
Intra	VCP	P55072	NSFL1C	Homo sapiens	Q9UNZ2	Anti Tag CoIP	20414249
Intra	VCP	P55072	NSFL1C	Homo sapiens	Q9UNZ2	ITC	21645854
Intra	VCP	P55072	NSFL1C	Homo sapiens	Q9UNZ2	Anti Bait CoIP	20414249
Intra	VCP	P55072	NSFL1C	Homo sapiens	Q9UNZ2	ITC	26712280
Intra	VCP	P55072	NSFL1C	Homo sapiens	Q9UNZ2	Anti Tag CoIP	26496610
Intra	VCP	P55072	NSFL1C	Homo sapiens	Q9UNZ2	Y2H Prey Pooling	25416956
Intra	VCP	P55072	NSFL1C	Homo sapiens	Q9UNZ2	BRET	29997244
Intra	VCP	P55072	NSFL1C	Homo sapiens	Q9UNZ2	Validated Y2H	25416956
Intra	VCP	P55072	NSFL1C	Homo sapiens	Q9UNZ2	Anti Tag CoIP	33961781
Intra	VCP	P55072	NSFL1C	Homo sapiens	Q9UNZ2	Filter Binding	16275660
Intra	VCP	P55072	NSFL1C	Homo sapiens	Q9UNZ2	Lumier	29997244
Intra	VCP	P55072	PSMA1	Homo sapiens	P25786	Y2H Prey Pooling	25416956
Intra	VCP	P55072	PSMA1	Homo sapiens	P25786	Validated Y2H	25416956
Intra	VCP	P55072	RNF8	Homo sapiens	O76064	Y2H Array	25416956
Intra	VCP	P55072	GRB2	Homo sapiens	P62993	Y2H Array	25814554
Intra	VCP	P55072	GRB2	Homo sapiens	P62993	Lumier	25814554
Intra	VCP	P55072	CUL4A	Homo sapiens	Q13619	Anti Tag CoIP	22466964
Intra	VCP	P55072	UBXN4	Homo sapiens	Q92575	Anti Tag CoIP	18775313
Intra	VCP	P55072	UBXN4	Homo sapiens	Q92575	Anti Tag CoIP	35271311
Intra	VCP	P55072	UBXN4	Homo sapiens	Q92575	BRET	29997244
Intra	VCP	P55072	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	VCP	P55072	LNX1	Homo sapiens	Q8TBB1	Y2H Array	29892012
Intra	VCP	P55072	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	25416956
Intra	VCP	P55072	DTNB	Homo sapiens	O60941	Validated Y2H	25416956
Intra	VCP	P55072	DTNB	Homo sapiens	O60941	Y2H Array	31515488
Intra	VCP	P55072	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	25416956
Intra	VCP	P55072	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	VCP	P55072	NTAQ1	Homo sapiens	Q96HA8	Y2H Array	25416956
Intra	VCP	P55072	CEP19	Homo sapiens	Q96LK0	Validated Y2H	25416956
Intra	VCP	P55072	CEP19	Homo sapiens	Q96LK0	Validated Y2H	32296183
Intra	VCP	P55072	CEP19	Homo sapiens	Q96LK0	Y2H Prey Pooling	25416956
Intra	VCP	P55072	UBOX5	Homo sapiens	O94941	Validated Y2H	25416956
Intra	VCP	P55072	UBOX5	Homo sapiens	O94941	Y2H Prey Pooling	25416956
Intra	VCP	P55072	UBE4B	Homo sapiens	B1AQ61	Anti Tag CoIP	20414249
Intra	VCP	P55072	ATXN3	Homo sapiens	P54252-1	Pull Down	16525503
Intra	VCP	P55072	ATXN3	Homo sapiens	P54252-1	Anti Bait CoIP	20414249
Intra	VCP	P55072	ATXN3	Homo sapiens	P54252-1	Peptide Array	16525503
Intra	VCP	P55072	ATXN3	Homo sapiens	P54252-1	Pull Down	12944474
Intra	VCP	P55072	ATXN3	Homo sapiens	P54252-1	Anti Tag CoIP	20414249

Cross: Cross-species interaction Intra: Intraspecies interaction

VCP Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82630	VCP Antibody (YA2375)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P82630A	VCP Antibody (YA2375)(PBS only)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P84401	VCP Antibody (YA4098)	WB, ICC/IF, FC, ELISA	Human, Mouse
HY-P84401A	VCP Antibody (YA4098)(PBS only)	WB, ICC/IF, FC, ELISA	Human, Mouse

Related Diseases

Diseases	Alias
Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia	Ibmpfd Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia Pagetoid Amyotrophic Lateral Sclerosis Pagetoid Neuroskeletal Syndrome Inclusion Body Myopathy With Paget Disease Of Bone And/Or Frontotemporal Dementia Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone And/Or Frontotemporal Dementia Multisystem Proteinopathy Limb-Girdle Muscular Dystrophy With Paget Disease Of Bone Inclusion Body Myopathy With Paget'S Disease Of Bone And Frontotemporal Dementia Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dement Lower Motor Neuron Degeneration With Paget-Like Bone Disease Muscular Dystrophy, Limb-Girdle, With Paget Disease Of Bone Myopathy, Inclusion Body, With Early-Onset Paget Disease And Frontotemporal Dementia
Movement Disease	Movement Disorders Movement Disorder
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1	FTDALS1 Frontotemporal Dementia And/Or Motor Neuron Disease Ftdmnd Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia Alsftd Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1 Frontotemporal Dementia With Motor Neuron Disease Ftdals Ftd-Als Ftd-Mnd Frontotemporal Dementia With Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1 Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1 Frontotemporal Lobar Degeneration Grn-Related Frontotemporal Dementia
Myofibrillar Myopathy	Desmin Related Myopathy Myotilinopathy Myopathy, Myofibrillar Alpha Beta Crystallinopathy Desmin Storage Myopathy Desminopathy Filaminopathy Protein Surplus Myopathy Zaspopathy Myofibrillar Myopathies Myopathy, Myofibrillar, Desmin-Related Myopathy, Desmin Storage Mfm - [Myofibrillar Myopathy]
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Amyotrophic Lateral Sclerosis Type 15	Amyotrophic Lateral Sclerosis 15, With Or Without Frontotemporal Dementia Als15 Amyotrophic Lateral Sclerosis 15
Supranuclear Palsy, Progressive, 1	Progressive Supranuclear Palsy Steele-Richardson-Olszewski Syndrome Supranuclear Palsy, Progressive Psp Progressive Supranuclear Ophthalmoplegia PSNP1 Familial Progressive Supranuclear Palsy Richardson'S Syndrome Psp Syndrome Progressive Supranuclear Palsy 1 Supranuclear Palsy Progressive Ophthalmoplegia, Supranuclear, Progressive Steele-Richardson-Olszewksi Syndrome
Amyotrophic Lateral Sclerosis 16, Juvenile	Amyotrophic Lateral Sclerosis Type 16 ALS16 Amyotrophic Lateral Sclerosis 16 Sclerosis, Lateral, Amyotrophic, Type 16, Juvenile
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone With Or Without Frontotemporal Dementia 1	Ibmpfd1 Msp1 Multisystem Proteinopathy 1
Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone With Or Without Frontotemporal Dementia 2	Ibmpfd2 Msp2 Multisystem Proteinopathy 2
Amyotrophic Lateral Sclerosis 6 With Or Without Frontotemporal Dementia	ALS6 Amyotrophic Lateral Sclerosis 6, With Or Without Frontotemporal Dementia Amyotrophic Lateral Sclerosis 6 Without Frontotemporal Dementia Amyotrophic Lateral Sclerosis 6
Muscle Tissue Disease
Dysgraphia	Agraphia
Werner Syndrome	Werner'S Syndrome WRN Adult Progeria Ws Adult Premature Ageing Syndrome Adult Premature Aging Syndrome Werners Syndrome
Aphasia
Dementia	Dementias Presenile Dementia Alzheimer Type Dementia Alzheimer Sclerosis Alzheimer Disease Dementia Alzheimer Dementia Primary Degenerative Alzheimer Type Dementia End Stage Alzheimer'S Dementia Alzheimer'S Type Atypical Dementia Alzheimer Type Presenile Dementia Early Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 2 Dementia In Alzheimer Disease With Early Onset Early Onset Alzheimer Type Dementia, Uncomplicated Primary Degenerative Alzheimer Type Dementia, Early Onset Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated Alzheimer Disease Dementia With Early Onset Presenile Sclerosis Presenile Brain Sclerosis Presenile Alzheimer Brain Sclerosis Late Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 1 Dementia In Alzheimer Disease With Late Onset Primary Degenerative Alzheimer Type Dementia, Late Onset Sdat - [Senile Dementia, Alzheimer Type] Alzheimer Disease Dementia With Late Onset Late Onset Alzheimer Brain Sclerosis Senile Alzheimer Brain Disease Senile Alzheimer Brain Sclerosis Senile Primary Degenerative Alzheimer Type Dementia Senile Dementia Of The Alzheimer Type Arteriosclerotic Dementia Strategic-Infarct Dementia Post Stroke Dementia Vascular Cognitive Impairment Vascular Dementia Dementia Of The Lewy Body Type Dementia With Lewy Bodies Sdlt - [Senile Dementia Of The Lewy Body Type] Senile Dementia Of The Lewy Body Type Alcohol-Related Dementia Alcoholic Dementia Nos Alcohol-Induced Dementia Alcoholic Brain Syndrome Chronic Alcoholic Brain Syndrome Alcohol Dementia Late Onset Alcoholic Psychosis Residual And Late-Onset Alcohol-Induced Psychotic Disorder Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder Late-Onset Psychoactive Substance-Induced Psychotic Disorder Inhalant Dementia Volatile Solvents Dementia Dementia In Paralysis Agitans Pdd - [Parkinson Disease Dementia] Dementia Syndrome Of Parkinson Disease Dementia In Parkinson Disease Parkinson Related Dementia Dementia In Huntington Chorea Hiv - [Human Immunodeficiency Virus] Dementia Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex Aids Related Dementia Dementia Due To Niacin Deficiency
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7	Ftd3 Frontotemporal Dementia, Chromosome 3-Linked Amyotrophic Lateral Sclerosis, Chmp2b-Related Chromosome 3-Linked Frontotemporal Dementia FTDALS7 Chmp2b-Related Frontotemporal Dementia Amyotrophic Lateral Sclerosis 17, Formerly Als17, Formerly Amyotrophic Lateral Sclerosis Type 17 Dtm1 Ftd-3 Ftd-Chmp2b Als17 Amyotrophic Lateral Sclerosis 17 Sclerosis, Lateral, Amyotrophic, Type 17 Dementia, Frontotemporal, Chromosome 3-Linked
Prosopagnosia
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Myositis	Idiopathic Inflammatory Myopathy Idiopathic Inflammatory Myositis Iim Imm Idiopathic Inflammatory Myopathies Myopathy, Familial Idiopathic Inflammatory Inflammatory Disorder Of Muscle Idiopathic Inflammatory Myopathy, Familial Inflammatory Myopathy, Idiopathic Myopathies Idiopathic Inflammatory Familial Idiopathic Inflammatory Myopathy
Muscular Dystrophy	Muscular Dystrophies Congenital Md Congenital Muscular Dystrophy Cmd Mdc Dystrophy, Muscular Gower'S Muscular Dystrophy Progressive Musclular Dystrophy Pseudohypertrophic Atrophy Pseudohypertrophic Muscle Paralysis Pseudohypertrophic Muscular Atrophy Pseudohypertrophic Muscular Dystrophy Pseudohypertrophic Paralysis Pseudomuscular Hypertrophy
Writing Disorder
Nominal Aphasia	Anomia Anomic Aphasia
Tooth Disease	Tooth Diseases Teeth Disease Tooth Disorders
Motor Neuron Disease	Anterior Horn Cell Disease Motor Neuron Diseases Mnd - [Motor Neurone Disease] Lou Gehrig Disease Creeping Palsy Creeping Paralysis Bulbar Motor Neuron Disease Bulbar Syndrome Anterior Horn Cell Disorder Hereditary Motor Neuron Disease
Dementia, Lewy Body	Lewy Body Dementia Lewy Body Disease Diffuse Lewy Body Disease Dementia With Lewy Bodies DLB Autosomal Dominant Diffuse Lewy Body Disease Cortical Lewy Body Disease Dementia, Lewy Body, Susceptibility To Lewy Body Dementia, Susceptibility To Senile Dementia Of The Lewy Body Type Dementia Of The Lewy Body Type Lbd Diffuse Lewy Body Disease With Gaze Palsy Dysphasic Dementia Hereditary Lewy Body Type Senile Dementia Lewy Body Variant Of Alzheimer Disease Lewy Bodies Lewy Body Dlbd - [Diffuse Lewy Body Disease] Clbd - [Cortical Lewy Body Disease]
Mammary Paget'S Disease	Paget'S Disease Mammary Paget Disease Paget'S Disease Of The Breast Paget Disease Of The Breast Paget'S Disease Of The Nipple Paget'S Disease, Mammary Paget Cell Neoplasm Paget Disease Of The Nipple Pagets Disease Mammary Osteitis Deformans
Inclusion Body Myopathy With Early-Onset Paget Disease With Or Without Frontotemporal Dementia 1	IBMPFD1 Multisystem Proteinopathy 1 Pagetoid Amyotrophic Lateral Sclerosis Pagetoid Neuroskeletal Syndrome Lower Motor Neuron Degeneration With Paget-Like Bone Disease Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia Msp1 Muscular Dystrophy, Limb-Girdle, With Paget Disease Of Bone Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia 1 Limb-Girdle Muscular Dystrophy With Paget Disease Of Bone Inclusion Body Myopathy Without Early-Onset Paget Disease And Frontotemporal Dementia 1
Lateral Sclerosis	Primary Lateral Sclerosis Adult-Onset Primary Lateral Sclerosis Adult-Onset Pls Motor Neuron Disease Pls Pls - [Primary Lateral Sclerosis] Lateral Spinal Sclerosis Lateral Complete Paralysis Lateral Incomplete Paralysis Lateral Paralysis
Cerebellar Disease	Cerebellar Diseases Cerebellar Dysfunction Cerebellar Abnormality Cerebellar Disorders
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Autosomal Dominant Cerebellar Ataxia	Spinocerebellar Ataxia Adca Pierre Marie Cerebellar Ataxia Ataxia, Spinocerebellar Sca Autosomal Dominant Spinocerebellar Ataxia Spinocerebellar Ataxias
Spinal And Bulbar Muscular Atrophy, X-Linked 1	Kennedy Disease Sbma Spinal And Bulbar Muscular Atrophy Kennedy'S Disease X-Linked Spinal And Bulbar Muscular Atrophy SMAX1 Kd Kennedy Spinal And Bulbar Muscular Atrophy Spinobulbar Muscular Atrophy Bulbospinal Muscular Atrophy, X-Linked Bulbospinal Neuronopathy, X-Linked Recessive Xbsn Spinal And Bulbar Muscular Atrophy Of Kennedy Bulbospinal Muscular Atrophy X-Linked Bulbospinal Amyotrophy Bulbo-Spinal Atrophy, X-Linked Spinal Bulbar Muscular Atrophy X-Linked Bulbo-Spinal Atrophy X-Linked Spinal Bulbar Muscular Atrophy X-Linked Bsma X-Linked Bulbospinal Muscular Atrophy Spinal And Bulbar Muscular Atrophy X-Linked 1 Bulbospinal Muscular Atrophy X-Linked Bulbospinal Neuronopathy X-Linked Recessive Kennedy Disease) Kennedy Syndrome Atrophy, Muscular, Spinal And Bulbar, Kennedy Type Atrophy, Muscular, Spinobulbar Bulbospinal Neuronopathy
Machado-Joseph Disease	SCA3 MJD Spinocerebellar Ataxia 3 Azorean Disease Spinocerebellar Ataxia Type 3 Azorean Neurologic Disease Spinopontine Atrophy Nigrospinodentatal Degeneration Spinocerebellar Atrophy Spinocerebellar Atrophy Iii Spinocerebellar Atrophy Type 3 Azorean Ataxia Azorean Disease Of The Nervous System Machado Disease Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia Disease, Machado-Joseph Ataxia, Spinocerebellar
Alzheimer Disease 7	Ad7 Alzheimer'S Disease 7 Alzheimer Disease, Familial, 7 Alzheimer Disease-7 Alzheimer Disease, Familial 7
Associative Agnosia
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies
Neuronal Ceroid Lipofuscinosis	Hereditary Ceroid Lipofuscinosis Batten Disease Ncl Neuronal Ceroid-Lipofuscinoses Lipofuscinosis, Ceroid, Neuronal Juvenile Neuronal Ceroid Lipofuscinosis Cerebromacular Dystrophy Cerebromacular Degeneration Ceroid-Lipofuscinosis Ncl - [Neuronal Ceroid Lipofuscinosis] Amaurotic Familial Idiocy Amaurotic Idiocy Amaurotic Idiot Neuronal Lipofuscinosis Pigmentary Retinal Lipoid Neuronal Heredodegeneration
Cortical Deafness
Agraphia
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Familial Spastic Paraparesis Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 6	FTDALS6 Amyotrophic Lateral Sclerosis 14 With Or Without Frontotemporal Dementia, Formerly Als14, Formerly Als14 Amyotrophic Lateral Sclerosis 14, With Or Without Frontotemporal Dementia Sclerosis, Lateral, Amyotrophic, Type 14, With/Without Frontotemporal Dementia
Amyotrophic Lateral Sclerosis Type 14	Als14 Amyotrophic Lateral Sclerosis 14 Amyotrophic Lateral Sclerosis, With Or Without Frontotemporal Dementia Amyotrophic Lateral Sclerosis 14 With Or Without Frontotemporal Dementia
Myopathy	Muscular Diseases Myopathies
Spastic Paraplegia-Paget Disease Of Bone Syndrome
Primary Biliary Cholangitis	Primary Biliary Cirrhosis Biliary Liver Cirrhosis Chronic Nonsuppurative Destructive Cholangitis Familial Primary Biliary Cirrhosis Pbc Hanot Syndrome Cholestatic Cirrhosis Biliary Cirrhosis Primary Liver Cirrhosis, Biliary Hanot'S Cirrhosis Biliary Cirrhosis Pericholangiolic Biliary Cirrhosis Tannhauser-Magendantz Syndrome Hanot-Rossle Syndrome Hypertrophic Cirrhosis Todd Cirrhosis Hanot Cirrhosis Charcot Cirrhosis Mahon-Tannhauser Syndrome Toxic Cirrhosis Hypertrophic Biliary Cirrhosis Monolobular Cirrhosis Unilobar Cirrhosis Xanthomatous Biliary Cirrhosis
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Progressive Non-Fluent Aphasia	Non-Fluent Variant Ppa Non-Fluent Primary Progressive Aphasia Agramatic Variant Of Ppa Agramatic Variant Of Primary Progressive Aphasia Progressive Nonfluent Aphasia Primary Progressive Non Fluent Aphasia Primary Progressive Nonfluent Aphasia
Progressive Muscular Atrophy	Progressive Spinal Muscular Atrophy Pure Progressive Muscular Atrophy Pma Hereditary Spinal Muscle Atrophy Pma - [Progressive Muscular Atrophy] Progressive Muscle Atrophy Progressive Spinal Muscle Atrophy Duchenne-Aran Atrophy Duchenne-Aran Muscle Atrophy Hereditary Sma - [Spinal Muscle Atrophy]
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Muscular Disease
Nonaka Myopathy	Gne Myopathy Hibm Distal Myopathy With Rimmed Vacuoles Hereditary Inclusion Body Myopathy Ibm2 Inclusion Body Myopathy, Quadriceps-Sparing Qsm Dmrv Distal Myopathy, Nonaka Type Inclusion Body Myopathy 2 Inclusion Body Myopathy, Autosomal Recessive NM Nonaka Distal Myopathy Myopathy, Distal, With Or Without Rimmed Vacuoles Inclusion Body Myopathy, Hereditary, Autosomal Recessive Inclusion Body Myopathy Type 2 Quadriceps-Sparing Myopathy Quadriceps Sparing Myopathy Rimmed Vacuole Myopathy Inclusion Body Myopathy 2, Autosomal Recessive, Formerly Ibm2, Formerly Hibm2 Hereditary Inclusion Body Myopathy Type 2 Inclusion Body Myopathy 2, Autosomal Recessive Myopathy, Distal, With Rimmed Vacuoles Inclusion Body Myopathy Autosomal Recessive Myopathy, Inclusion Body, Type 2 Myopathy, Nonaka
Amyotrophic Lateral Sclerosis Type 6	Amyotrophic Lateral Sclerosis 6, Autosomal Recessive Als6 Amyotrophic Lateral Sclerosis 6, With Or Without Frontotemporal Dementia Autosomal Recessive Amyotrophic Lateral Sclerosis 6 Sclerosis, Lateral, Amyotrophic, Type Type 6 Amyotrophic Lateral Sclerosis 6
Spinocerebellar Ataxia 2	Spinocerebellar Ataxia Type 2 SCA2 Amyotrophic Lateral Sclerosis 13 Spinocerebellar Degeneration With Slow Eye Movements SDSEM Spinocerebellar Atrophy Ii Olivopontocerebellar Atrophy Ii Opca2 Cerebellar Degeneration With Slow Eye Movements Wadia-Swami Syndrome Amyotrophic Lateral Sclerosis Type 13 ALS13 Olivopontocerebellar Atrophy Holguin Type Spinocerebellar Ataxia Cuban Type Olivopontocerebellar Atrophy, Holguin Type Spinocerebellar Ataxia, Cuban Type Amyotrophic Lateral Sclerosis, Susceptibility To, 13 Olivopontocerebellar Atrophy 2 Sca 2 Spinocerebellar Ataxia With Slow Eye Movements Spinocerebellar Atrophy 2 Wadia Swami Syndrome Opca Ii Spinocerebellar Ataxia-2 Ataxia, Spinocerebellar, Type 2
Charcot-Marie-Tooth Disease, Axonal, Type 2e	Charcot-Marie-Tooth Disease Type 2 CMT2E CMT2S CMT2Y Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease Axonal Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2s Charcot-Marie-Tooth Disease, Type 2e Hereditary Motor And Sensory Neuropathy Type 2 Charcot-Marie-Tooth Neuropathy, Type 2s Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s Charcot-Marie-Tooth Disease, Axonal, Type 2y Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y Charcot-Marie-Tooth Neuropathy, Type 2y Charcot-Marie-Tooth Disease, Type 2y Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e Charcot-Marie-Tooth Neuropathy Type 2e Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation Cmt2 Due To Vcp Mutation Charcot-Marie-Tooth Disease Type 2s Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Cmt2 Charcot-Marie-Tooth Neuropathy, Type 2e Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type Hereditary Motor And Sensory Neuropathy Okinawa Type Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y Charcot-Marie-Tooth Neuropathy Type 2y Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s Charcot-Marie-Tooth Neuropathy Type 2s Charcot-Marie-Tooth Type 2 Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y Charcot-Marie-Tooth Disease 2e Charcot-Marie-Tooth Disease Axonal Type 2e Charcot-Marie-Tooth Disease Neuronal Type 2e Charcot-Marie-Tooth Disease 2s Charcot-Marie-Tooth Neuropathy Axonal Type 2s Charcot-Marie-Tooth Disease 2y Charcot-Marie-Tooth Disease, Type 2 Hereditary Motor And Sensory-Neuropathy Type Ii
Ehlers-Danlos Syndrome, Spondylodysplastic Type, 3	Spondylocheirodysplasia, Ehlers-Danlos Syndrome-Like Scd-Eds EDSSPD3 Ehlers-Danlos Syndrome Spondylodysplastic Type 3 Ehlers-Danlos Syndrome, Spondylocheirodysplastic Type Slc39a13-Related Spondylodysplastic Ehlers-Danlos Syndrome Slc39a13-Related Speds Slc39a13-Related Spondylodysplastic Eds Spondylocheirodysplastic Ehlers-Danlos Syndrome Speds-Slc39a13 Ehlers-Danlos Syndrome-Like Spondylocheirodysplasia Ehlers-Danlos Syndrome, Spondylodysplastic, Type 3
Neuromuscular Disease	Neuromuscular Diseases Neuromuscular Disorders Neuromuscular Disorder
Breast Adenocarcinoma	Mammary Adenocarcinoma Adenocarcinoma Of Breast
Adult-Onset Distal Myopathy Due To Vcp Mutation
Familial Expansile Osteolysis	FEO Mccabe Disease Osteolysis, Familial Expansile Polyostotic Osteolytic Dysplasia, Hereditary Expansile Hepod Expansile Osteolysis, Familial Eof Hereditary Expansile Polyostotic Osteolytic Dysplasia
Pick Disease Of Brain	Pick Disease Pick Disease Of The Brain Lobar Atrophy Of Brain Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions Pick'S Disease Behavioral Variant Of Frontotemporal Dementia Dementia In Pick'S Disease Lobar Atrophy Of The Brain Bvftd Bv-Ftd PIDB Picks Disease
Paget'S Disease Of Bone	Osteitis Deformans Paget Disease Of Bone Osseous Paget'S Disease Paget Disease Of Bone, Familial Bone Paget Disease Familial Paget'S Disease Of Bone Paget'S Bone Disease Familial Paget Disease Of Bone Paget Disease, Bone Pdb Pagets Bone Disease
Speech And Communication Disorders	Language Disorder Communication Disorder Language Disorders Communication Disorders Speech Language Disorder Speech-Language Disorder Communication Impairment Speech And Language Disorder
Multisystem Proteinopathy
Perry Syndrome	Parkinsonism With Alveolar Hypoventilation And Mental Depression PERRYS

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-138233	KUS121	Modulator	99.76%	Phase 2
HY-177414	BB-1701	Inhibitor	98.81%	Phase 2
HY-12861	CB-5083	Inhibitor	99.90%	Phase 1

Pre-clinical Phase

Bioactive Molecules (26)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15713	NMS-873	Inhibitor	99.92%	Unkown
HY-123872	MSC1094308	Inhibitor	99.89%	Unkown
HY-128870	Mal-PEG2-VCP-Eribulin		99.79%	Unkown
HY-157508	VCP Activator 1	Activator	99.94%	Unkown
HY-15714	NMS-859	Inhibitor	98.02%	Unkown
HY-168323	UP163	Activator	98.08%	Unkown
HY-168324	UP158	Activator	99.88%	Unkown
HY-RS15621	VCP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-168325	UP12	Activator	97.69%	Unkown
HY-124776	NPD8733	Inhibitor	99.92%	Unkown
HY-130084	Mal-PEG2-VCP-NB		98.25%	Unkown
HY-139606	VCP/p97 inhibitor-1	Inhibitor	98.64%	Unkown
HY-RS15623	Vcp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-113608	VCP171	Modulator	99.18%	Unkown
HY-128871	VCP-Eribulin		/	Unkown
HY-148122	NW 1028	Inhibitor	/	Unkown
HY-160981	Mal-PEG4-VCP-NB		/	Unkown
HY-160982	Mal-PEG3-VCP-NB		/	Unkown
HY-168007	NSC804515	Inhibitor	/	Unkown
HY-174847	VCP/p97 IN-2	Inhibitor	/	Unkown
HY-174984	VCP/p97 IN-3		/	Unkown
HY-177549	Fmoc-PEG6-VCP-Eribulin		/	Unkown
HY-183257	ATI-1		/	Unkown
HY-184291	VCP/p97 IN-4		/	Unkown
HY-RS15622	Vcp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-118460	ACJI-99C	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	VCP	VGNC	VGNC:66933
Rattus norvegicus	VCP	RGD	RGD:621595
Canis familiaris	VCP	VGNC	VGNC:48243
Mus musculus	VCP	MGD	MGI:99919
Bos taurus	VCP	VGNC	VGNC:36780
Macaca mulatta	VCP	VGNC	VGNC:78762
Others	VCP	NCBI