DCD - dermcidin Gene

Also Known as PIF; AIDD; DSEP; HCAP; DCD-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 117159

About DCD

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:54,644,589-54,648,365 (from NCBI)

This gene has 3 transcripts (splice variants), 17 orthologues and 1 paralogue. Low expression observed in reference dataset.

Summary

This antimicrobial gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has Antibacterial and Antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in Cancer patients. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

DCD Products (2)

mRNA	Protein	Name
NM_001300854.2	NP_001287783.1	dermcidin isoform 2 preproprotein
NM_053283.4	NP_444513.1	dermcidin isoform 1 preproprotein

DCD Protein Structure

Dermcidin

0
100
110 a.a.

Protein Preferred Names	Protein Names
dermcidin	diffusible survival/evasion peptide

DCD Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DCD	P81605	ASPH	Homo sapiens	Q12797-6	Validated Y2H	32296183
Intra	DCD	P81605	APPBP2	Homo sapiens	Q92624	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DCD Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71729	DCD Protein, Human (P.pastoris, His)	P81605-1 (Y20-L110)	≥ 95%, as determined by reducing SDS-PAGE.

DCD Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89769	Dermcidin Antibody (YA9113)	WB, ICC/IF, IF-Tissue, IHC-P, IP	human, mouse, rat

Related Diseases

Diseases	Alias
Root Caries	Cementum Caries Dental Caries Of Root Surface
Spondylometaphyseal Dysplasia With Corneal Dystrophy	SMDCD Spondylometaphyseal Dysplasia-Corneal Dystrophy Syndrome Smd-Corneal Dystrophy Syndrome
Netherton Syndrome	NETH Ns Netherton Disease Comel-Netherton Syndrome Erythroderma, Ichthyosiform, With Hypotrichosis And Hyper-Ige Bamboo Hair Syndrome Ichthyosis Linearis Circumflexa Ichthyosiform Erythroderma With Hypotrichosis And Hyper-Ige Ilc Nts N Syndrome
Cholinergic Urticaria
Angiomyoma	Vascular Leiomyoma
Miliaria	Eccrine Miliaria Heat Rash Sweat Rash Sweat Retention Syndrome
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Sweat Gland Disease	Sweat Gland Diseases

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12308	TCS 2314	Antagonist	≥99.0%	Unkown
HY-N0154S	Neohesperidin Dihydrochalcone-d3		/	Unkown
HY-RS03572	DCD Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Bioactive MoleculesInhibitory Antibodies (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990178	Anti-Mouse NKG2D/CD314 Antibody (CX5)		95.00%	Unkown
HY-P99656	Iladatuzumab		96.97%	Unkown
HY-P992138	Vadalentamig	Inhibitor	/	Unkown
HY-P990829	Anti-NKG2D/CD314 Antibody (1D11)	Inhibitor	95%	Unkown
HY-P990804	Anti-Mouse NKG2D/CD314 Antibody (HMG2D)	Inhibitor	/	Unkown