Cd44 - CD44 antigen Gene

Also Known as Ly-24; Pgp-1; HERMES

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12505

Summary

Enables hyaluronic acid binding activity and type II transforming growth factor beta receptor binding activity. Contributes to cytokine binding activity and cytokine receptor activity. Involved in several processes, including negative regulation of T cell activation; positive regulation of protein phosphorylation; and regulation of intracellular signal transduction. Acts upstream of or within several processes, including Wnt signaling pathway; morphogenesis of a branching epithelium; and wound healing involved in inflammatory response. Located in basolateral plasma membrane; external side of plasma membrane; and microvillus. Part of macrophage migration inhibitory factor receptor complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and limb. Human ortholog(s) of this gene implicated in breast carcinoma (multiple); carcinoma (multiple); and prostate Cancer. Orthologous to human CD44 (CD44 molecule (Indian blood group)). [provided by Alliance of Genome Resources, Apr 2022]

Cd44 Products (6)

mRNA Protein Name
NM_001039150.1 NP_001034239.1 CD44 antigen isoform b precursor
NM_001039151.1 NP_001034240.1 CD44 antigen isoform c precursor
NM_001177785.1 NP_001171256.1 CD44 antigen isoform d precursor
NM_001177786.1 NP_001171257.1 CD44 antigen isoform e precursor
NM_001177787.1 NP_001171258.1 CD44 antigen isoform f precursor
NM_009851.2 NP_033981.2 CD44 antigen isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cargo receptor activity IDA
IDA: Inferred from direct assay
1703543 MGI
enables cargo receptor activity IMP
IMP: Inferred from mutant phenotype
26528478 MGI
contributes to cytokine binding IDA
IDA: Inferred from direct assay
18056708 MGI
contributes to cytokine receptor activity IDA
IDA: Inferred from direct assay
17045821 MGI
enables hyaluronic acid binding IMP
IMP: Inferred from mutant phenotype
10926769 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7535771 MGI
enables type II transforming growth factor beta receptor binding IPI
IPI: Inferred from physical interaction
25065622 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Wnt signaling pathway IDA
IDA: Inferred from direct assay
19056892 MGI
acts upstream of or within branching involved in prostate gland morphogenesis IMP
IMP: Inferred from mutant phenotype
9374396 MGI
acts upstream of or within branching involved in ureteric bud morphogenesis IMP
IMP: Inferred from mutant phenotype
10926769 MGI
involved in hyaluronan catabolic process IDA
IDA: Inferred from direct assay
26528478 MGI
involved in hyaluronan catabolic process IMP
IMP: Inferred from mutant phenotype
26528478 MGI
involved in negative regulation of CD4-positive, alpha-beta T cell proliferation IMP
IMP: Inferred from mutant phenotype
25065622 MGI
involved in negative regulation of DNA damage response, signal transduction by p53 class mediator IMP
IMP: Inferred from mutant phenotype
17045821 MGI
involved in negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
25065622 MGI
involved in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
IMP: Inferred from mutant phenotype
17045821 MGI
involved in negative regulation of mature B cell apoptotic process IDA
IDA: Inferred from direct assay
18056708 MGI
involved in negative regulation of regulatory T cell differentiation IMP
IMP: Inferred from mutant phenotype
25065622 MGI
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
17045821 MGI
acts upstream of or within positive regulation of gene expression IGI
IGI: Inferred from genetic interaction
9847236 MGI
involved in receptor-mediated endocytosis IDA
IDA: Inferred from direct assay
26528478 MGI
involved in receptor-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
26528478 MGI
acts upstream of or within wound healing involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
11935029 MGI
Cellular Component GO Annotation Evidence References Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
10027409 MGI
located in cell surface IDA
IDA: Inferred from direct assay
9324354 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
7538697 MGI
part of macrophage migration inhibitory factor receptor complex IDA
IDA: Inferred from direct assay
17045821 MGI
located in microvillus IDA
IDA: Inferred from direct assay
9472040 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
9374396 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CD44 antigen

  • ECMR-III

  • GP90 lymphocyte homing/adhesion receptor

  • HUTCH-I

  • PGP-I

  • extracellular matrix receptor III

  • hermes antigen

  • hyaluronate receptor

  • lymphocyte antigen 24

  • phagocytic glycoprotein 1

  • phagocytic glycoprotein I

Recombinant Cd44 Proteins

Cat. No. Product Name Accession Purity
HY-P74291 CD44 Protein, Mouse (HEK293, His) NP_001034240.1 (Q25-T224) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-154812 Gintemetostat Inhibitor 99.81% Unkown
HY-149897 HA-CD44 interaction inhibitor 2 Inhibitor 99.36% Unkown
HY-149898 HA-CD44 interaction inhibitor 1 Inhibitor 99.34% Unkown
HY-B0633D Hyaluronic acid sodium (MW 200-1560) Ligand 99.41% Unkown
HY-B0633E Hyaluronic acid, low endotoxin Ligand / Unkown
HY-P5352 Hyaluronan-IN-1 Inhibitor 99.84% Unkown
HY-W015860 3-Methylbenzene-1,2-diamine Ligand / Unkown
HY-181781 LSD1-IN-48 Inhibitor / Unkown
HY-E70182 Hyaluronidase 2 Inhibitor / Unkown
HY-175809 SRT6 Inhibitor / Unkown
Inhibitory Antibodies (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99126 Anti-Mouse/Human CD44 Antibody (IM7) Inhibitor 99.07% Unkown
HY-P992437 PF-03475952 Inhibitor / Unkown
HY-P991756 Anti-Mouse CD44 Antibody (KM703) Inhibitor / Unkown
HY-P991559 Anti-CD44 Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd44 NCBI NCBI:960