Ptk2 - PTK2 protein tyrosine kinase 2 Gene

Also Known as FAK; FRNK; Fadk; FADK 1; p125FAK

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14083

About Ptk2

Chromosome 15: 73,076,951-73,295,129 reverse strand.GRCm39:CM001008.3

This gene has 16 transcripts (splice variants), 230 orthologues, 32 paralogues and is associated with 64 phenotypes. Ubiquitous expression in cortex adult (RPKM 12.3), CNS E11.5 (RPKM 11.8) and 28 other tissues.

Summary

Enables non-membrane spanning protein tyrosine kinase activity. Involved in positive regulation of cell population proliferation; positive regulation of ubiquitin-dependent protein catabolic process; and protein phosphorylation. Acts upstream of or within several processes, including blood vessel morphogenesis; generation of neurons; and peptidyl-tyrosine autophosphorylation. Located in several cellular components, including apical plasma membrane; focal adhesion; and lamellipodium. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and yolk sac. Human ortholog(s) of this gene implicated in leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Orthologous to human PTK2 (protein tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ptk2 Products (3)

mRNA Protein Name
NM_001358045.1 NP_001344974.1 focal adhesion kinase 1 isoform 3
NM_001358046.1 NP_001344975.1 focal adhesion kinase 1 isoform 4
NM_007982.2 NP_032008.2 focal adhesion kinase 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables non-membrane spanning protein tyrosine kinase activity IMP
IMP: Inferred from mutant phenotype
18297732 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7479864 MGI
enables protein tyrosine kinase activity EXP
EXP: Inferred from Experiment
16298995 MGI
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
7529876 MGI
enables protein tyrosine kinase activity IMP
IMP: Inferred from mutant phenotype
25059660 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
15967814 MGI
acts upstream of axonogenesis IMP
IMP: Inferred from mutant phenotype
15378065 MGI
acts upstream of or within blood vessel development IMP
IMP: Inferred from mutant phenotype
12595342 MGI
acts upstream of or within cellular response to transforming growth factor beta stimulus IDA
IDA: Inferred from direct assay
21829547 MGI
acts upstream of or within central nervous system neuron axonogenesis IMP
IMP: Inferred from mutant phenotype
15378065 MGI
acts upstream of or within endothelial cell migration IMP
IMP: Inferred from mutant phenotype
15967814 MGI
acts upstream of or within extracellular matrix organization IMP
IMP: Inferred from mutant phenotype
14642275 MGI
acts upstream of or within microtubule cytoskeleton organization IDA
IDA: Inferred from direct assay
12941275 MGI
acts upstream of or within negative regulation of autophagy IDA
IDA: Inferred from direct assay
27994061 MGI
acts upstream of or within negative regulation of autophagy IMP
IMP: Inferred from mutant phenotype
27994061 MGI
acts upstream of or within negative regulation of axonogenesis IMP
IMP: Inferred from mutant phenotype
15378065 MGI
acts upstream of or within negative regulation of organ growth IGI
IGI: Inferred from genetic interaction
16374517 MGI
acts upstream of or within negative regulation of synapse assembly IMP
IMP: Inferred from mutant phenotype
15378065 MGI
acts upstream of or within neuron migration IDA
IDA: Inferred from direct assay
12941275 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
14642275 MGI
acts upstream of or within nuclear migration IDA
IDA: Inferred from direct assay
12941275 MGI
acts upstream of organ growth IGI
IGI: Inferred from genetic interaction
16374517 MGI
acts upstream of or within peptidyl-tyrosine autophosphorylation IDA
IDA: Inferred from direct assay
27994061 MGI
acts upstream of or within peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
27994061 MGI
involved in peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
7529876 MGI
involved in peptidyl-tyrosine phosphorylation IMP
IMP: Inferred from mutant phenotype
18297732 MGI
acts upstream of or within positive regulation of cardiac muscle hypertrophy IDA
IDA: Inferred from direct assay
27994061 MGI
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
18206965 MGI
involved in positive regulation of ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
18206965 MGI
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
7529876 MGI
acts upstream of or within protein autophosphorylation IMP
IMP: Inferred from mutant phenotype
2132399 MGI
involved in regulation of modification of postsynaptic actin cytoskeleton IDA
IDA: Inferred from direct assay
19553453 MGI
involved in regulation of modification of postsynaptic actin cytoskeleton IMP
IMP: Inferred from mutant phenotype
19553453 MGI
acts upstream of or within vasculogenesis IMP
IMP: Inferred from mutant phenotype
15967814 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
10742111 MGI
located in focal adhesion IDA
IDA: Inferred from direct assay
10699171 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
19553453 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
19553453 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
15728191 MGI
located in nucleus IDA
IDA: Inferred from direct assay
18206965 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ptk2 Protein Structure

FERM_N_2

FERM_N_2: pfam18038 (34 - 129)

B41

B41: smart00295 (35 - 257)

FERM_C_FAK1

FERM_C_FAK1: cd13190 (253 - 363)

PTKc_FAK

PTKc_FAK: cd05056 (414 - 683)

Focal_AT

Focal_AT: pfam03623 (915 - 1044)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1052 a.a.
Protein Preferred Names Protein Names

focal adhesion kinase 1

  • focal adhesion kinase-related nonkinase

  • focal ashension kinase 1

  • pp125FAK

  • protein-tyrosine kinase 2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-122844B Ifebemtinib tosylate Inhibitor / Phase 3

Pre-clinical Phase

Bioactive Molecules (23)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-123919 TL13-112 Inhibitor 98.01% Unkown
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-111546 BI-3663 Inhibitor 99.84% Unkown
HY-171770 dAurAB5 99.03% Unkown
HY-124625 BI-4464 Inhibitor 98.64% Unkown
HY-122582 TL13-12 Degrader 98.16% Unkown
HY-148061 DB1113 99.86% Unkown
HY-130521 Pomalidomide-amido-PEG3-C2-NH2 99.11% Unkown
HY-103471 Y11 Activator 98.34% Unkown
HY-148063 DB0614 99.92% Unkown
HY-148066 DB0662 Degrader 99.66% Unkown
HY-130422 Tos-PEG4-t-butyl ester / Unkown
HY-136194 TL13-22 Inhibitor 99.71% Unkown
HY-RS11399 PTK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11400 Ptk2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26981 Ptk2b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-136195 TL13-110 Inhibitor / Unkown
HY-176198 BI-0319 Degrader / Unkown
HY-182478 MDL-27048 Inhibitor / Unkown
HY-RS11401 Ptk2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11402 PTK2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183946 NVP-TAC544 Inhibitor / Unkown
HY-RS20473 Ptk2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptk2 NCBI NCBI:5747