2. Gene
  3. Ptk2 - PTK2 protein tyrosine kinase 2 Gene

Ptk2 - PTK2 protein tyrosine kinase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as FAK; FRNK; Fadk; FADK 1; p125FAK

Gene ID: 14083 | Gene type: protein coding

About Ptk2

Chromosome 15: 73,076,951-73,295,129 reverse strand.GRCm39:CM001008.3

This gene has 16 transcripts (splice variants), 230 orthologues, 32 paralogues and is associated with 64 phenotypes. Ubiquitous expression in cortex adult (RPKM 12.3), CNS E11.5 (RPKM 11.8) and 28 other tissues.

Summary

Enables non-membrane spanning protein tyrosine kinase activity. Involved in positive regulation of cell population proliferation; positive regulation of ubiquitin-dependent protein catabolic process; and protein phosphorylation. Acts upstream of or within several processes, including blood vessel morphogenesis; generation of neurons; and peptidyl-tyrosine autophosphorylation. Located in several cellular components, including apical plasma membrane; focal adhesion; and lamellipodium. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and yolk sac. Human ortholog(s) of this gene implicated in leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Orthologous to human PTK2 (protein tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ptk2 Products(3)

mRNA Protein Name
NM_001358045.1 NP_001344974.1 focal adhesion kinase 1 isoform 3
NM_001358046.1 NP_001344975.1 focal adhesion kinase 1 isoform 4
NM_007982.2 NP_032008.2 focal adhesion kinase 1 isoform 1

Ptk2 Protein Structure

FERM_N_2

FERM_N_2: pfam18038 (34 - 129)

B41

B41: smart00295 (35 - 257)

FERM_C_FAK1

FERM_C_FAK1: cd13190 (253 - 363)

PTKc_FAK

PTKc_FAK: cd05056 (414 - 683)

Focal_AT

Focal_AT: pfam03623 (915 - 1044)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1052 a.a.
Protein Preferred Names Protein Names

focal adhesion kinase 1

focal adhesion kinase-related nonkinase

focal ashension kinase 1

pp125FAK

protein-tyrosine kinase 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-111546 BI-3663 Inhibitor 99.90% Unkown
HY-123919 TL13-112 Inhibitor 98.15% Unkown
HY-124625 BI-4464 Inhibitor 99.27% Unkown
HY-148063 DB0614 98.80% Unkown
HY-122582 TL13-12 Inhibitor 98.06% Unkown
HY-130422 Tos-PEG4-t-butyl ester ≥97.0% Unkown
HY-148061 DB1113 99.28% Unkown
HY-130521 Pomalidomide-amido-PEG3-C2-NH2 99.55% Unkown
HY-136194 TL13-22 Inhibitor / Unkown
HY-136195 TL13-110 Inhibitor / Unkown
HY-148065 FMF-06-098-1 / Unkown
HY-RS11399 PTK2 Human Pre-designed siRNA Set A / Unkown
HY-RS11400 Ptk2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS11401 Ptk2 Rat Pre-designed siRNA Set A / Unkown
HY-RS11402 PTK2B Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptk2 NCBI NCBI:5747