CSF2RB - colony stimulating factor 2 receptor subunit beta Gene

Also Known as CD131; IL3RB; IL5RB; SMDP5; CDw131; betaGMR

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1439

About CSF2RB

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:36,913,628-36,940,439 (from NCBI)

This gene has 3 transcripts (splice variants), 132 orthologues, 7 paralogues and is associated with 2 phenotypes. Biased expression in appendix (RPKM 40.5), lymph node (RPKM 21.2) and 12 other tissues.

Summary

The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq, Jul 2008]

CSF2RB Products (2)

mRNA Protein Name
NM_000395.3 NP_000386.1 cytokine receptor common subunit beta isoform 2 precursor
NM_001410827.1 NP_001397756.1 cytokine receptor common subunit beta isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables coreceptor activity IDA
IDA: Inferred from direct assay
7957082 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
1495999 GOA
Biological Process GO Annotation Evidence References Source
involved in cell surface receptor signaling pathway via JAK-STAT IDA
IDA: Inferred from direct assay
18692472 GOA
involved in granulocyte-macrophage colony-stimulating factor signaling pathway IDA
IDA: Inferred from direct assay
18692472 GOA
involved in interleukin-3-mediated signaling pathway IDA
IDA: Inferred from direct assay
8649415 GOA
involved in interleukin-5-mediated signaling pathway IDA
IDA: Inferred from direct assay
1495999 GOA
involved in positive regulation of leukocyte proliferation IDA
IDA: Inferred from direct assay
18692472 GOA
Cellular Component GO Annotation Evidence References Source
part of granulocyte macrophage colony-stimulating factor receptor complex IDA
IDA: Inferred from direct assay
27396825 GOA
is active in plasma membrane IDA
IDA: Inferred from direct assay
1495999 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSF2RB Protein Structure

IL6Ra-bind

IL6Ra-bind: Interleukin-6 receptor alpha chain, binding (245 - 338)

fn3

fn3: Fibronectin type III domain (341 - 419)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 897 a.a.
Protein Preferred Names Protein Names

cytokine receptor common subunit beta

  • GM-CSF/IL-3/IL-5 receptor common beta subunit

CSF2RB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CSF2RB P32927 IL5RA Homo sapiens Q01344
Saturation Binding
1495999
Intra
CSF2RB P32927 IL3 Homo sapiens P08700
Saturation Binding
18692472
Intra
CSF2RB P32927 IL5 Homo sapiens P05113
Saturation Binding
1495999
Intra
CSF2RB P32927 IL5 Homo sapiens P05113
Crosslink
1495999
Intra
CSF2RB P32927 JAK2 Homo sapiens O60674
Anti Bait CoIP
18692472
Intra
CSF2RB P32927 JAK2 Homo sapiens O60674
Anti Bait CoIP
16437163
Intra
CSF2RB P32927 ITGB1 Homo sapiens P05556
Anti Bait CoIP
20802515
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CSF2RB Proteins

Cat. No. Product Name Accession Purity
HY-P73032 EPOR-CD131 Heterodimer Protein, Human (HEK293, Fc) P19235 (A25-P250)&P32927 (W17-W443) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75608 CD131 Protein, Human (HEK293, His) P32927-1 (W17-W443) ≥ 95%, as determined by reducing SDS-PAGE.

CSF2RB Antibodies

Cat. No. Product Name Application Reactivity
HY-P83661 IL-3RB Antibody(YA3396) WB, IHC-P, FC, ELISA Human, Mouse, Rat
HY-P84264 IL-3RB Antibody (YA3961) WB, IHC-P, FC, ELISA Human, Mouse, Rat
HY-P84264A IL-3RB Antibody (YA3961)(PBS only) WB, IHC-P, FC, ELISA Human, Mouse, Rat
HY-P84960 IL-3RB Antibody (YA7078)

Related Diseases

Diseases Alias
Surfactant Metabolism Dysfunction, Pulmonary, 5

  • SMDP5

  • Pulmonary Alveolar Proteinosis 5

  • Pap Due To Csf2rb Deficiency

  • Csf2rb Deficiency

  • Pulmonary Surfactant Metabolism Dysfunction 5

  • Pap5

  • Surfactant Metabolism Dysfunction, Pulmonary, Type 5
Hereditary Pulmonary Alveolar Proteinosis

  • Congenital Pap

  • Congenital Pulmonary Alveolar Proteinosis

  • Pulmonary Alveolar Proteinosis, Congenital
Pulmonary Alveolar Proteinosis
Autosomal Dominant Beta Thalassemia

  • Inclusion Body Beta-Thalassemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03233 CSF2RB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18705 Csf2rb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25192 Csf2rb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990094 Trabikibart 99.17% Unkown
HY-P990975 Birinkibart 98.26% Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CSF2RB VGNC VGNC:27756
Macaca mulatta CSF2RB VGNC VGNC:71518
Canis familiaris CSF2RB VGNC VGNC:39656
Rattus norvegicus CSF2RB RGD RGD:620189
Felis catus CSF2RB VGNC VGNC:61216
Others CSF2RB NCBI