Il1b - interleukin 1 beta Gene

Also Known as Il-1b; IL-1beta

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16176

About Il1b

Chromosome 2: 129,206,490-129,213,059 reverse strand.GRCm39:CM000995.3

This gene has 3 transcripts (splice variants), 233 orthologues, 6 paralogues and is associated with 31 phenotypes. Broad expression in spleen adult (RPKM 1.3), lung adult (RPKM 1.) and 19 other tissues.

Summary

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by Caspase 1. The encoded protein plays a role in thymocyte proliferation and is involved in the inflammatory response. [provided by RefSeq, Aug 2015]

Il1b Products (1)

mRNA Protein Name
NM_008361.4 NP_032387.1 interleukin-1 beta

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cytokine activity IDA
IDA: Inferred from direct assay
12925700 MGI
enables receptor ligand activity IDA
IDA: Inferred from direct assay
16260493 MGI
enables receptor ligand activity IGI
IGI: Inferred from genetic interaction
16260493 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of JNK cascade IDA
IDA: Inferred from direct assay
16260493 MGI
acts upstream of JNK cascade IGI
IGI: Inferred from genetic interaction
16260493 MGI
acts upstream of or within astrocyte activation IDA
IDA: Inferred from direct assay
28377412 MGI
involved in cellular response to interleukin-17 IDA
IDA: Inferred from direct assay
30294880 MGI
acts upstream of or within ectopic germ cell programmed cell death IGI
IGI: Inferred from genetic interaction
11536012 MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: Inferred from mutant phenotype
11536012 MGI
acts upstream of or within interleukin-1 beta production IGI
IGI: Inferred from genetic interaction
19158679 MGI
acts upstream of interleukin-6 production IDA
IDA: Inferred from direct assay
15292196 MGI
acts upstream of or within interleukin-6 production IDA
IDA: Inferred from direct assay
15843532 MGI
acts upstream of or within leukocyte migration IDA
IDA: Inferred from direct assay
15034066 MGI
acts upstream of or within macrophage cytokine production IDA
IDA: Inferred from direct assay
15843532 MGI
involved in negative regulation of D-glucose transmembrane transport IDA
IDA: Inferred from direct assay
16865359 MGI
involved in negative regulation of MAP kinase activity IDA
IDA: Inferred from direct assay
16865359 MGI
involved in negative regulation of adiponectin secretion IDA
IDA: Inferred from direct assay
16865359 MGI
involved in negative regulation of insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
16865359 MGI
involved in negative regulation of lipid metabolic process IDA
IDA: Inferred from direct assay
16865359 MGI
involved in negative regulation of synaptic transmission IMP
IMP: Inferred from mutant phenotype
20739563 MGI
acts upstream of or within neutrophil chemotaxis IDA
IDA: Inferred from direct assay
12925700 MGI
acts upstream of or within positive regulation of JNK cascade IDA
IDA: Inferred from direct assay
16260493 MGI
acts upstream of or within positive regulation of JNK cascade IGI
IGI: Inferred from genetic interaction
16260493 MGI
involved in positive regulation of JNK cascade IGI
IGI: Inferred from genetic interaction
20739563 MGI
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
12598651 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
16260493 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IGI
IGI: Inferred from genetic interaction
16260493 MGI
acts upstream of or within positive regulation of chemokine production IDA
IDA: Inferred from direct assay
12925700 MGI
involved in positive regulation of fever generation IDA
IDA: Inferred from direct assay
19940926 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: Inferred from direct assay
19666510 MGI
acts upstream of or within positive regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
12925700 MGI
involved in positive regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
20554964 MGI
involved in positive regulation of lipid catabolic process IDA
IDA: Inferred from direct assay
16865359 MGI
involved in positive regulation of p38MAPK cascade IGI
IGI: Inferred from genetic interaction
20739563 MGI
involved in positive regulation of prostaglandin secretion IDA
IDA: Inferred from direct assay
19940926 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19734906 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
19666510 MGI
involved in positive regulation of vascular endothelial growth factor production IMP
IMP: Inferred from mutant phenotype
12598651 MGI
involved in regulation of defense response to virus by host IDA
IDA: Inferred from direct assay
24784232 MGI
involved in regulation of nitric-oxide synthase activity IDA
IDA: Inferred from direct assay
15899045 MGI
acts upstream of or within response to ATP IDA
IDA: Inferred from direct assay
15905573 MGI
acts upstream of or within response to ATP IMP
IMP: Inferred from mutant phenotype
18490713 MGI
acts upstream of or within response to carbohydrate IDA
IDA: Inferred from direct assay
16301672 MGI
acts upstream of or within response to lipopolysaccharide IDA
IDA: Inferred from direct assay
16423834 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
18490713 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
11016935 MGI
located in secretory granule IDA
IDA: Inferred from direct assay
16423834 MGI
located in vesicle IDA
IDA: Inferred from direct assay
15905573 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il1b Protein Structure

IL1_propep

IL1_propep: pfam02394 (0 - 101)

IL1

IL1: smart00125 (119 - 264)

  • 0
  • 100
  • 200
  • 269 a.a.
Protein Preferred Names Protein Names

interleukin-1 beta

  • IL-1 beta

Recombinant Il1b Proteins

Cat. No. Product Name Accession Purity
HY-P7073 IL-1 beta Protein, Mouse P10749 (V118-S269) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7073A IL-1 beta Protein, Mouse (CHO) P10749 (V118-S269) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700187AF Animal-Free IL-1 beta Protein, Mouse (His) P10749 (V118-S269) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1117 MMK1 99.71% Unkown
HY-141852 STAMBP-IN-1 Inhibitor 98.73% Unkown
HY-111662 Fc 11a-2 Inhibitor 99.75% Unkown
HY-147105A (+)-LRH-1 agonist-2 Modulator 99.38% Unkown
HY-RS06716 IL1B Human Pre-designed siRNA Set A / Unkown
HY-162168 Anti-inflammatory agent 71 Inhibitor / Unkown
HY-179407 LT-104A Inhibitor / Unkown
HY-P1117A MMK1 TFA / Unkown
HY-RS06717 Il1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06718 Il1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174627 Human IL1B mRNA / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99139 Anti-Mouse IL-1b Antibody (B122) 99% Unkown
HY-P990563 CDP-484 99.34% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il1b NCBI NCBI:3553