Limk1 - LIM-domain containing, protein kinase Gene

Also Known as Limk; KIZ-1; LIMK-1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16885

About Limk1

Chromosome 5: 134,684,893-134,717,452 reverse strand.GRCm39:CM000998.3

This gene has 6 transcripts (splice variants), 262 orthologues, 23 paralogues and is associated with 11 phenotypes. Ubiquitous expression in cerebellum adult (RPKM 15.2), whole brain E14.5 (RPKM 14.2) and 27 other tissues.

Summary

This gene encodes a member of the LIM kinase family of proteins. This protein is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein also stimulates axon growth and may play a role in brain development. Homozygous knockout mice for this gene exhibit reduced bone mass, abnormal neuronal morphology and altered synaptic function. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Limk1 Products (2)

mRNA	Protein	Name
NM_001305875.1	NP_001292804.1	LIM domain kinase 1 isoform 2
NM_010717.3	NP_034847.1	LIM domain kinase 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10431247	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of axon extension	IGI IGI: Inferred from genetic interaction	16204183	MGI
acts upstream of or within positive regulation of axon extension	IGI IGI: Inferred from genetic interaction	16204183	MGI
acts upstream of or within positive regulation of stress fiber assembly	IGI IGI: Inferred from genetic interaction	15199148	MGI
acts upstream of stress fiber assembly	IGI IGI: Inferred from genetic interaction	15199148	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16204183	MGI
located in focal adhesion	IDA IDA: Inferred from direct assay	15023529	MGI
located in lamellipodium	IDA IDA: Inferred from direct assay	25107909	MGI
located in male germ cell nucleus	IDA IDA: Inferred from direct assay	16399995	MGI
located in membrane	IDA IDA: Inferred from direct assay	24792215	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	16204183	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15023529	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Limk1 Protein Structure

LIM1_LIMK1

LIM2_LIMK1

PDZ

STKc_LIMK1

0
100
200
300
400
500
600
647 a.a.

Protein Preferred Names	Protein Names
LIM domain kinase 1

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-157442	GLPG3312	Inhibitor	98.63%	Phase 1

Pre-clinical Phase

Bioactive Molecules (18)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18305	BMS-5	Inhibitor	99.84%	Unkown
HY-136848	SM1-71	Inhibitor	96.09%	Unkown
HY-18304	BMS-3	Inhibitor	99.89%	Unkown
HY-122630	TH-257	Inhibitor	98.36%	Unkown
HY-148061	DB1113		99.86%	Unkown
HY-120097	R-10015	Inhibitor	99.72%	Unkown
HY-19353	SR7826	Inhibitor	99.30%	Unkown
HY-120025	CRT0105950	Inhibitor	99.76%	Unkown
HY-151539	TH470	Inhibitor	99.62%	Unkown
HY-128062	LIMK1 inhibitor BMS-4	Inhibitor	99.1%	Unkown
HY-14227	LIMK-IN-1	Inhibitor	99.33%	Unkown
HY-174229	SM311	Inhibitor	/	Unkown
HY-175656	MDI-117740	Inhibitor	/	Unkown
HY-125444	TH251	Inhibitor	/	Unkown
HY-N10868	8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide	Inhibitor	/	Unkown
HY-12659B	LX7101 monohydrochloride	Inhibitor	/	Unkown
HY-169605	LIMK1 inhibitor 1	Inhibitor	/	Unkown
HY-111103	CZh226	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Limk1	NCBI	NCBI:3984