Bbc3 - BCL2 binding component 3 Gene

Also Known as PUMA; PUMA/JFY1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 170770

Summary

Predicted to enable ATPase binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; positive regulation of apoptotic process; and positive regulation of cysteine-type endopeptidase activity. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; and toxin transport. Predicted to be located in mitochondrial envelope. Predicted to be active in mitochondrion. Predicted to colocalize with lysosome. Is expressed in several structures, including central nervous system; immune system; liver; retina; and skeletal muscle. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human BBC3 (BCL2 binding component 3). [provided by Alliance of Genome Resources, Apr 2022]

Bbc3 Products (9)

mRNA Protein Name
NM_001382549.1 NP_001369478.1 bcl-2-binding component 3 isoform a
NM_001382550.1 NP_001369479.1 bcl-2-binding component 3 isoform a
NM_001382552.1 NP_001369481.1 bcl-2-binding component 3 isoform a
NM_001403671.1 NP_001390600.1 bcl-2-binding component 3 isoform a
NM_001403672.1 NP_001390601.1 bcl-2-binding component 3 isoform a
NM_001403673.1 NP_001390602.1 bcl-2-binding component 3 isoform a
NM_001403674.1 NP_001390603.1 bcl-2-binding component 3 isoform b
NM_001403675.1 NP_001390604.1 bcl-2-binding component 3 isoform c
NM_133234.3 NP_573497.1 bcl-2-binding component 3 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16151013 MGI
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IGI
IGI: Inferred from genetic interaction
20818388 MGI
acts upstream of T cell apoptotic process IMP
IMP: Inferred from mutant phenotype
16832056 MGI
acts upstream of or within cellular response to ionizing radiation IGI
IGI: Inferred from genetic interaction
16286009 MGI
involved in determination of adult lifespan IGI
IGI: Inferred from genetic interaction
20818388 MGI
acts upstream of fibroblast apoptotic process IMP
IMP: Inferred from mutant phenotype
14500851 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
IMP: Inferred from mutant phenotype
16151013 MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
16407291 MGI
acts upstream of lymphocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
14500851 MGI
acts upstream of or within positive regulation of T cell apoptotic process IMP
IMP: Inferred from mutant phenotype
16832056 MGI
involved in positive regulation of cysteine-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
21159964 MGI
acts upstream of positive regulation of establishment of protein localization to mitochondrion IMP
IMP: Inferred from mutant phenotype
16705087 MGI
acts upstream of or within positive regulation of establishment of protein localization to mitochondrion IMP
IMP: Inferred from mutant phenotype
16705087 MGI
acts upstream of or within positive regulation of fibroblast apoptotic process IMP
IMP: Inferred from mutant phenotype
14500851 MGI
acts upstream of or within positive regulation of lymphocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
14500851 MGI
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
21159964 MGI
involved in positive regulation of thymocyte apoptotic process IGI
IGI: Inferred from genetic interaction
20818388 MGI
involved in response to endoplasmic reticulum stress IDA
IDA: Inferred from direct assay
21159964 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bcl-2-binding component 3

  • BH3-only

  • Bcl-2 binding component 3

  • p53 up-regulated modulator of apoptosis

Bbc3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Bbc3 Q99ML1 BCL2L1 Homo sapiens Q07817-1
Anti Bait CoIP
16151013
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-B2035 Pretilachlor 99.25% Unkown
HY-RS01381 BBC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-179507 p53 Activator 17 / Unkown
HY-B2035R Pretilachlor (Standard) / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bbc3 NCBI NCBI:27113