Sphk1 - sphingosine kinase 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 170897

About Sphk1

Primary_assembly 10: 101,758,711-101,764,240 forward strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 277 orthologues, 4 paralogues and is associated with 7 phenotypes. Biased expression in Thymus (RPKM 63.), Kidney (RPKM 34.3) and 7 other tissues.

Summary

Enables D-erythro-sphingosine kinase activity. Involved in several processes, including cyclooxygenase pathway; positive regulation of NF-kappaB transcription factor activity; and positive regulation of macromolecule metabolic process. Located in several cellular components, including axon; cytosol; and synaptic vesicle. Biomarker of adenocarcinoma and high grade glioma. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human SphK1 (sphingosine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Sphk1 Products (6)

mRNA Protein Name
NM_001270809.1 NP_001257738.1 sphingosine kinase 1 isoform b
NM_001270807.1 NP_001257736.1 sphingosine kinase 1 isoform b
NM_001270808.1 NP_001257737.1 sphingosine kinase 1 isoform b
NM_133386.3 NP_596877.2 sphingosine kinase 1 isoform b
NM_001270811.1 NP_001257740.1 sphingosine kinase 1 isoform a
NM_001270810.1 NP_001257739.1 sphingosine kinase 1 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables D-erythro-sphingosine kinase activity IDA
IDA: Inferred from direct assay
15715670 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16888242 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to growth factor stimulus IEP
IEP: Inferred from expression pattern
16135093 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
17158340 RGD
involved in cellular response to starvation IEP
IEP: Inferred from expression pattern
16959847 RGD
involved in cyclooxygenase pathway IDA
IDA: Inferred from direct assay
18723875 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
18723875 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
17158340 RGD
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
28284343 RGD
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
17200676 RGD
involved in positive regulation of interleukin-17 production IMP
IMP: Inferred from mutant phenotype
28284343 RGD
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
15289497 RGD
involved in positive regulation of neurotransmitter secretion IMP
IMP: Inferred from mutant phenotype
17325039 RGD
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
16313513 RGD
involved in regulation of neuroinflammatory response IMP
IMP: Inferred from mutant phenotype
28284343 RGD
involved in regulation of tumor necrosis factor-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
28284343 RGD
involved in response to ATP IEP
IEP: Inferred from expression pattern
17200676 RGD
involved in response to amine IEP
IEP: Inferred from expression pattern
17164439 RGD
involved in response to interleukin-1 IEP
IEP: Inferred from expression pattern
15855330 RGD
involved in response to magnesium ion IEP
IEP: Inferred from expression pattern
18028875 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
15715670 RGD
involved in response to progesterone IEP
IEP: Inferred from expression pattern
17164439 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
17325039 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
17325039 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sphk1 Protein Structure

PLN02958

PLN02958: cl29912 (85 - 418)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 458 a.a.
Protein Preferred Names Protein Names

sphingosine kinase 1

  • SK 1

  • SPK 1

  • acetyltransferase SPHK1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (25)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15425 PF-543 Inhibitor 99.85% Unkown
HY-15425A PF-543 Citrate Inhibitor 99.47% Unkown
HY-124042 K6PC-5 Activator 99.27% Unkown
HY-119016 SK1-I Inhibitor 98.83% Unkown
HY-19794 MP-A08 Inhibitor 98.0% Unkown
HY-12892 SKI-178 Inhibitor 99.29% Unkown
HY-101572 MHP Activator 98.57% Unkown
HY-101805 SK1-IN-1 Inhibitor 98.10% Unkown
HY-147282 Amgen-23 Inhibitor 98.11% Unkown
HY-148707 SphK1&2-IN-1 Inhibitor 98.47% Unkown
HY-120268A SLM6031434 hydrochloride Inhibitor 99.1% Unkown
HY-117563 CAY10621 Inhibitor 99.3% Unkown
HY-120152A SLP7111228 hydrochloride Inhibitor 98.01% Unkown
HY-15425B PF-543 hydrochloride Inhibitor / Unkown
HY-112385 ABC294735 Inhibitor / Unkown
HY-150615 SphK1-IN-2 Inhibitor / Unkown
HY-143296 SphK1-IN-1 Inhibitor / Unkown
HY-178992 SphK1-IN-4 Inhibitor / Unkown
HY-120268 SLM6031434 Inhibitor / Unkown
HY-12896 SLR080811 Inhibitor / Unkown
HY-120152 SLP7111228 Inhibitor / Unkown
HY-184271 SphK1-IN-5 Inhibitor / Unkown
HY-124368 RB-042 Inhibitor / Unkown
HY-148262 SphK1-IN-3 Inhibitor / Unkown
HY-12900 RB-005 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sphk1 NCBI NCBI:8877