Smarca4 - SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Gene

Also Known as brg-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 171379

Summary

Enables chromatin binding activity. Involved in negative regulation of transcription, DNA-templated; nucleosome disassembly; and spermatid development. Located in nucleus. Part of SWI/SNF complex. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 4; hepatocellular carcinoma; lung non-small cell carcinoma; and rhabdoid Cancer. Orthologous to human SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4). [provided by Alliance of Genome Resources, Apr 2022]

Smarca4 Products (1)

mRNA Protein Name
NM_134368.1 NP_599195.1 transcription activator BRG1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
16452305 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
8895581 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
9001244 RGD
Biological Process GO Annotation Evidence References Source
involved in chromatin remodeling IDA
IDA: Inferred from direct assay
9001244 RGD
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
12192000 RGD
involved in nucleosome disassembly IDA
IDA: Inferred from direct assay
9001244 RGD
involved in spermatid development IEP
IEP: Inferred from expression pattern
22215678 RGD
Cellular Component GO Annotation Evidence References Source
part of SWI/SNF complex IDA
IDA: Inferred from direct assay
9001244 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription activator BRG1

  • ATP-dependent helicase SMARCA4

  • BAF190A

  • BRG1-associated factor 190A

  • SNF2-beta

  • SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

  • protein brahma homolog 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-163410 AU-24118 Degrader 99.10% Phase 2
HY-159607 PRT3789 Degrader 98.08% Phase 2
HY-13030 (+)-JQ-1 Ligand 99.91% Phase 1

Pre-clinical Phase

Bioactive Molecules (46)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-145388 AU-15330 Degrader 99.89% Unkown
HY-128359 ACBI1 Degrader 99.34% Unkown
HY-168221 YD54 Degrader 98.74% Unkown
HY-173351 G-6599 Degrader 98.30% Unkown
HY-173333 PROTAC SMARCA2/4 degrader-38 Degrader 99.46% Unkown
HY-44012 SMARCA-BD ligand 1 for PROTAC Ligand 99.07% Unkown
HY-44012B SMARCA-BD ligand 1 for PROTAC hydrochloride Ligand 99.24% Unkown
HY-44012A SMARCA-BD ligand 1 for PROTAC dihydrochloride Ligand 98.08% Unkown
HY-46618 SMARCA2/4-ligand-8 Ligand 99.66% Unkown
HY-148381 A947 Degrader / Unkown
HY-185075 FHD-909 Inhibitor / Unkown
HY-159457 PROTAC SMARCA2/4 degrader-6 Degrader / Unkown
HY-162834 PROTAC SMARCA2/4 degrader-27 Degrader / Unkown
HY-163867 PROTAC SMARCA2/4 degrader-44 Degrader / Unkown
HY-169280 PXR Ligand 2 / Unkown
HY-170354 SMARCA2/4-ligand-4 Ligand / Unkown
HY-168252 BRM/BRG1 ligand 3 Ligand / Unkown
HY-170817 SMI-1074 Inhibitor / Unkown
HY-168248 BRM/BRG1 ligand 2 Ligand / Unkown
HY-159459 PROTAC SMARCA2/4 degrader-32 Degrader / Unkown
HY-159454 PROTAC SMARCA2/4 degrader-3 Degrader / Unkown
HY-163949 SMARCA2/4-IN-3 Inhibitor / Unkown
HY-153425 PROTAC SMARCA2/4 degrader-41 Degrader / Unkown
HY-162748 PROTAC SMARCA2/4 degrader-30 Degrader / Unkown
HY-162813 PROTAC SMARCA2/4 degrader-25 Degrader / Unkown
HY-162814 SMARCA2/4-ligand-3 Ligand / Unkown
HY-162815 PROTAC SMARCA2/4 degrader-26 Degrader / Unkown
HY-170347 PROTAC SMARCA2/4 degrader-36 Degrader / Unkown
HY-162745 PROTAC SMARCA2/4 degrader-42 Degrader / Unkown
HY-171774 PBRM1/SMARCA2,4-ligand-1 / Unkown
HY-175186 LO-3-62 Degrader / Unkown
HY-163864 PROTAC SMARCA2/4 degrader-11 Degrader / Unkown
HY-163865 PROTAC SMARCA2 degrader-13 Degrader / Unkown
HY-171765 SMARCA2/4-ligand-6 Ligand / Unkown
HY-159453 PROTAC SMARCA2/4 degrader-2 Degrader / Unkown
HY-162835 PROTAC SMARCA2/4 degrader-28 Degrader / Unkown
HY-161885 SMARCA2/4-IN-4 Inhibitor / Unkown
HY-159458 PROTAC SMARCA2/4 degrader-7 Degrader / Unkown
HY-159460 PROTAC SMARCA2/4 degrader-8 Degrader / Unkown
HY-170343 PROTAC SMARCA2 degrader-32 Degrader / Unkown
HY-178225 PROTAC SMARCA2/4 degrader-39 Degrader / Unkown
HY-159461 PROTAC SMARCA2/4 degrader-9 Degrader / Unkown
HY-163866 PROTAC SMARCA2/4 degrader-43 Degrader / Unkown
HY-W539427 BRM/BRG1 ligand 1 Ligand / Unkown
HY-159472 SMARCA2/4-ligand-1 Inhibitor / Unkown
HY-172446 SMARCA2/4-ligand-5 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smarca4 NCBI NCBI:6597