SMARCA4 - SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Gene

Also Known as BRG1; CSS4; SNF2; SWI2; MRD16; RTPS2; BAF190; SNF2L4; SNF2LB; hSNF2b; BAF190A; SNF2-beta

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6597

About SMARCA4

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,961,030-11,062,273 (from NCBI)

This gene has 54 transcripts (splice variants), 268 orthologues, 30 paralogues and is associated with 166 phenotypes. Ubiquitous expression in testis (RPKM 21.8), brain (RPKM 14.5) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

SMARCA4 Products (10)

mRNA	Protein	Name
NM_001128844.3	NP_001122316.1	transcription activator BRG1 isoform B
NM_001128845.2	NP_001122317.1	transcription activator BRG1 isoform C
NM_001128846.2	NP_001122318.1	transcription activator BRG1 isoform D
NM_001128847.4	NP_001122319.1	transcription activator BRG1 isoform E
NM_001128848.2	NP_001122320.1	transcription activator BRG1 isoform F
NM_001128849.3	NP_001122321.1	transcription activator BRG1 isoform A
NM_001374457.1	NP_001361386.1	transcription activator BRG1 isoform E
NM_001387283.1	NP_001374212.1	transcription activator BRG1 isoform A
NM_001411150.1	NP_001398079.1	transcription activator BRG1 isoform G
NM_003072.5	NP_003063.2	transcription activator BRG1 isoform B

SMARCA4 Protein Structure

QLQ

HSA

BRK

SNF2_N

Helicase_C

SnAC

Bromodomain

0
300
600
900
1200
1500
1679 a.a.

Protein Preferred Names	Protein Names
transcription activator BRG1	ATP-dependent helicase SMARCA4

SMARCA4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	SMARCA4	P51532	TERT	Homo sapiens	O14746	Anti Bait CoIP	19571879
Intra	SMARCA4	P51532	SMARCC1	Homo sapiens	Q92922	Anti Tag CoIP	35271311
Intra	SMARCA4	P51532	SMARCC1	Homo sapiens	Q92922	CoIP	12368262
Intra	SMARCA4	P51532	SMARCC1	Homo sapiens	Q92922	Anti Bait CoIP	15985610
Intra	SMARCA4	P51532	SMARCC1	Homo sapiens	Q92922	PLA	28420882
Intra	SMARCA4	P51532	SMARCC1	Homo sapiens	Q92922	Anti Bait CoIP	23540691
Intra	SMARCA4	P51532	SMARCC1	Homo sapiens	Q92922	Anti Bait CoIP	18303029
Intra	SMARCA4	P51532	SMARCC1	Homo sapiens	Q92922	Anti Tag CoIP	10078207
Intra	SMARCA4	P51532	SMARCC1	Homo sapiens	Q92922	Anti Bait CoIP	31759698
Intra	SMARCA4	P51532	SMARCC1	Homo sapiens	Q92922	Anti Bait CoIP	12917342
Intra	SMARCA4	P51532	SMARCB1	Homo sapiens	Q12824	Anti Bait CoIP	23540691
Intra	SMARCA4	P51532	SMARCB1	Homo sapiens	Q12824	Anti Tag CoIP	10078207
Intra	SMARCA4	P51532	SMARCB1	Homo sapiens	Q12824	Anti Bait CoIP	31759698
Intra	SMARCA4	P51532	SMARCB1	Homo sapiens	Q12824	Anti Bait CoIP	15985610
Intra	SMARCA4	P51532	SMARCB1	Homo sapiens	Q12824	CoIP	12368262
Intra	SMARCA4	P51532	SMARCB1	Homo sapiens	Q12824	Density Sedimentation	23540691
Intra	SMARCA4	P51532	SMARCB1	Homo sapiens	Q12824	Anti Tag CoIP	35271311
Intra	SMARCA4	P51532	SMARCD1	Homo sapiens	Q96GM5	Anti Bait CoIP	15985610
Intra	SMARCA4	P51532	SMARCD1	Homo sapiens	Q96GM5	Anti Bait CoIP	12917342
Intra	SMARCA4	P51532	SMARCD1	Homo sapiens	Q96GM5	Anti Tag CoIP	35271311
Intra	SMARCA4	P51532	H2AX	Homo sapiens	P16104	IF	20224553
Intra	SMARCA4	P51532	H2AX	Homo sapiens	P16104	Anti Tag CoIP	20224553
Intra	SMARCA4	P51532	RBPJ	Homo sapiens	Q06330	Anti Tag CoIP	23022380
Intra	SMARCA4	P51532	PBRM1	Homo sapiens	Q86U86	Anti Bait CoIP	15985610
Intra	SMARCA4	P51532	PBRM1	Homo sapiens	Q86U86	Anti Tag CoIP	35271311
Intra	SMARCA4	P51532	PBRM1	Homo sapiens	Q86U86	Anti Bait CoIP	22140357
Intra	SMARCA4	P51532	ARID2	Homo sapiens	Q68CP9	Anti Tag CoIP	35271311
Intra	SMARCA4	P51532	ARID2	Homo sapiens	Q68CP9	Anti Bait CoIP	15985610
Intra	SMARCA4	P51532	ARID2	Homo sapiens	Q68CP9	Anti Bait CoIP	22140357
Intra	SMARCA4	P51532	ARID1A	Homo sapiens	O14497	Anti Bait CoIP	15985610
Intra	SMARCA4	P51532	ARID1A	Homo sapiens	O14497	CoIP	12368262
Intra	SMARCA4	P51532	ARID1A	Homo sapiens	O14497	Anti Bait CoIP	23540691
Intra	SMARCA4	P51532	ARID1A	Homo sapiens	O14497	Y2H	11988099
Intra	SMARCA4	P51532	ARID1B	Homo sapiens	Q8NFD5	Anti Tag CoIP	35271311
Intra	SMARCA4	P51532	ARID1B	Homo sapiens	Q8NFD5	Anti Tag CoIP	12200431
Intra	SMARCA4	P51532	SYT-SSX1	Homo sapiens	A4PIV7	Anti Bait CoIP	23540691
Intra	SMARCA4	P51532	REST	Homo sapiens	Q13127	Anti Bait CoIP	12192000
Cross	SMARCA4	P51532	Nr3c1	Rattus norvegicus	P06536	Anti Bait CoIP	12917342

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SMARCA4 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P71784	SMARCA4 Protein, Human (P.pastoris, His)	P51532 (E700-F1246)	≥ 90%, as determined by reducing SDS-PAGE.

SMARCA4 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P80039	BRG1 Antibody (YA577)	WB, IHC-P, IHC-F, ICC/IF, FC, IF-Tissue	Human, Mouse, Rat, Pig
HY-P80575	BRG1 Antibody (YA817)	WB, ICC/IF, IP	Human, Mouse
HY-P80575A	BRG1 Antibody (YA817)(PBS only)	WB, ICC/IF, IP	Human, Mouse
HY-P85601	BRG1 Antibody (YA5293)	WB, ICC/IF, IP	Human, Mouse
HY-P86425	BRG1 Antibody (YA6117)	WB, IHC-P, ICC/IF, IP, ELISA	Mouse, Rat

Related Diseases

Diseases	Alias
Coffin-Siris Syndrome 4	CSS4 Mrd16 Mental Retardation, Autosomal Dominant 16 Autosomal Dominant Mental Retardation 16 Coffin-Siris Syndrome, Type 4
Rhabdoid Tumor Predisposition Syndrome 2	RTPS2 Tumor, Rhabdoid, Predisposition Syndrome, Type 2
Ovarian Small Cell Carcinoma	Small Cell Carcinoma Of The Ovary Scco Small Cell Ovarian Carcinoma
Smarca4-Deficient Sarcoma Of Thorax	Smarca4-Dts Smarca4-Deficient Thoracic Sarcoma
Atypical Teratoid Rhabdoid Tumor	Rhabdoid Tumor Predisposition Syndrome Rtps Atypical Teratoid/Rhabdoid Tumor Rhabdoid Predisposition Syndrome Familial Posterior Fossa Brain Tumor Of Infancy Familial Rhabdoid Tumor At/Rt Atypical Teratoid Rhabdoid Tumour Atypical Teratoid/Rhabdoid Tumour Rhabdoid Tumor Of The Cns Rhabdoid Tumour Of The Cns Familial Posterior Fossa Brain Tumor Syndrome Hereditary Swi/Snf Deficiency Syndrome Atrt
Coffin-Siris Syndrome 1	Coffin-Siris Syndrome Fifth Digit Syndrome Css CSS1 Mrd12 Mental Retardation, Autosomal Dominant 12 Hhid Dwarfism-Onychodysplasia Hypertrichosis, Hyperkeratosis, Mental Retardation, And Distinctive Facial Features Autosomal Dominant Mental Retardation 12 Short Stature-Onychodysplasia. Intellectual Disability With Absent Fifth Fingernail And Terminal Phalanx Mental Retardation With Hypoplastic Fifth Fingernails And Toenails Short Stature-Onychodysplasia Coffin-Siris Syndrome, Type 1 Mental Retardation, Autosomal Dominant, Type 12
Familial Hypercholesterolemia	Hyperlipoproteinemia Type Iia Familial Hyperbetalipoproteinaemia Familial Hypercholesteremia Fredrickson Type Iia Hyperlipoproteinemia Fredrickson Type Iia Lipidaemia Hyperbetalipoproteinemia Type Ii Hyperlipidemia Familial Hypercholesterolæmia Familial Hypercholesterolaemia Fh Hypercholesterolemia Familial Hyperlipoproteinemia Type Ii Hypercholesterolemia, Familial
Hypercholesterolemia, Familial, 1	Hypercholesterolemia FHCL1 Fhc Fh Hyperlipoproteinemia, Type Ii Hyperlipoproteinemia, Type Iia Hyper-Low-Density-Lipoproteinemia Hypercholesterolemic Xanthomatosis, Familial Ldl Receptor Disorder Hypercholesterolemia, Susceptibility To Hypercholesterolemia, Familial, Modifier Of Hypercholesterolemia, Familial, Due To Ldlr Defect, Modifier Of Ldl Cholesterol Level Qtl2 Hyperlipoproteinemia Type Ii Hypercholesterolemia, Familial, Type 1 High Cholesterol Increased Cholesterol Low-Density-Lipoid-Type Hyperlipoproteinemia Pure Hypercholesterolaemia Ldl - [Low Density Lipoprotein} Hyperlipoproteinemia Group A Hyperlipidaemia Pure Hypercholesterinaemia Cholesterolaemia Essential Cholesterolaemia Essential Hypercholesterolaemia Group A Hyperlipemia Increased Low Density Lipoprotein Low-Density-Lipoprotein-Type Low-Density-Lipoprotein-Type Hyperlipoproteinemia
Cerebral Palsy	Infantile Cerebral Palsy Mixed Cerebral Palsy Palsy Cerebral Palsy, Cerebral Cerebral Palsy, Mixed
Bap1 Tumor Predisposition Syndrome	Bap1-Related Tumor Predisposition Syndrome Common Syndrome Bap1 Cancer Syndrome Bap1-Tpds Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, And Other Internal Neoplasms Tumor Predisposition Syndrome Tumor Susceptibility Linked To Germline Bap1 Mutations Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, Other Internal Neoplasms Tumor Predisposition
Inherited Cancer-Predisposing Syndrome	Hereditary Cancer-Predisposing Syndrome
Ventricular Septal Defect	Ventricular Septal Defects Interventricular Septal Defect Heart Septal Defects, Ventricular Ventricular Septal Abnormality Interventricular Septum Defect Ventricular Septum Defect Vsd - [Ventricular Septum Defect] Congenital Ventricular Septal Defect Single Ventricular Septal Defect
Atrial Heart Septal Defect	Atrial Septal Defect Atrial Septal Defects Atrioseptal Defect Auricular Septal Defect Congenital Atrial Septal Defect Interatrial Septal Defect Interauricular Septal Defect Heart Septal Defects, Atrial Septal Defect, Atrial
Interatrial Communication	Asd Atrial Septal Defect Interauricular Communication
Cleft Palate, Isolated	Cleft Palate Isolated Cleft Palate CPI Cp Palatoschisis Cleft Palate Isolated Uranostaphyloschisis Congenital Fissure Of Palate Cleft Of Secondary Palate
Tumor Predisposition Syndrome 2	TPDS2 Mbd4-Associated Neoplasia Syndrome Mans Man
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Nasal Cavity Cancer	Nasal Cavity Carcinoma Malignant Neoplasm Of Nasal Cavities Malignant Tumor Of The Nasal Cavity Cancer Of Nasal Cavity Carcinoma Of Nasal Cavity Malignant Neoplasm Of Nasal Cavity Neoplasm Of Nasal Cavity
Small-Cell Carcinoma Of The Ovary Of Hypercalcemic Type	Hypercalcemic Type Ovarian Small Cell Carcinoma Small Cell Carcinoma Of The Ovary, Hypercalcemic Type Ovarian Small Cell Carcinoma, Hypercalcemic Type
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Schimke Immunoosseous Dysplasia	Schimke Immuno-Osseous Dysplasia SIOD Immunoosseous Dysplasia, Schimke Type Schimke Syndrome Immunoosseous Dysplasia Schimke Type Spondyloepiphyseal Dysplasia - Nephrotic Syndrome Spondyloepiphyseal Dysplasia Nephrotic Syndrome Spondyloepiphyseal Dysplasia-Nephrotic Syndrome
Large Cell Carcinoma With Rhabdoid Phenotype	Large Cell Lung Carcinoma With Rhabdoid Phenotype
Thymus Large Cell Carcinoma	Large Cell Carcinoma Of The Thymus Thymic Large Cell Neuroendocrine Carcinoma
Li-Fraumeni Syndrome	Sarcoma Family Syndrome Of Li And Fraumeni Sbla Syndrome LFS Li-Fraumeni Familiar Cancer Susceptibility Syndrome Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome Lfs1 Li Fraumeni Syndrome Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome Lfl Sbla Syndrome Li-Fraumeni-Like Syndrome Li-Fraumeni Syndrome 1
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Alpha Thalassemia-X-Linked Intellectual Disability Syndrome	Atr-X Syndrome Atr, Nondeletion Type Alpha-Thalassemia X-Linked Intellectual Disability Syndrome Atrx Syndrome Alpha-Thalassemia/Mental Retardation Syndrome Nondeletion Type Alpha Thalassemia Intellectual Disability Syndrome, Nondeletion Type, X-Linked X-Linked Alpha-Thalassemia/Intellectual Disability Syndrome Xlmr Hypotonic Face Syndrome Alpha Thalassemia X-Linked Intellectual Disability Syndrome Alpha Thalassemia X-Linked Mental Retardation Syndrome Alpha Thalassemia/Mental Retardation, X-Linked Alpha-Thalassemia X-Linked Mental Retardation Syndrome Alpha-Thalassemia/Mental Retardation Syndrome, Nondeletion Type X-Linked Alpha-Thalassemia/Mental Retardation Syndrome Xlmr-Hypotonic Face Syndrome Alpha-Thalassemia-X-Linked Intellectual Disability Syndrome Alpha-Thalassemia/Mental Retardation Syndrome, Nondeletion Type, X-Linked
Choroid Plexus Cancer	Choroid Plexus Carcinoma Choroid Plexus Neoplasms Choroid Plexus Neoplasm Tumor Of Choroid Plexus Tumor Of The Choroid Plexus Choroid Plexus Tumor Choroid Plexus Tumors Anaplastic Choroid Plexus Papilloma Choroid Plexus Papilloma Nos Papilloma Of Choroid Plexus Plexus Choroideus Papilloma Choroid Plexus Papilloma In Fourth Ventricle Plexus Choroideus Papilloma In Fourth Ventricle
Hypertrichosis
Kidney Rhabdoid Cancer	Rhabdoid Tumor Of The Kidney Kidney Rhabdoid Tumor Renal Rhabdoid Tumor
Autosomal Dominant Intellectual Developmental Disorder	Autosomal Dominant Mental Retardation Autosomal Dominant Non-Syndromic Mental Retardation Autosomal Dominant Non-Syndromic Intellectual Disability Mental Retardation, Autosomal Dominant
Sinonasal Undifferentiated Carcinoma	Highly Aggressive Undifferentiated Carcinoma Of The Nasal Cavity And Paranasal Sinuses Snuc
Alpha-Thalassemia Myelodysplasia Syndrome	ATMDS Acquired Hemoglobin H Disease Alpha-Thalassemia Myelodysplasia Syndrome, Somatic Acquired Hbh Disease Alpha-Thalassemia-Myelodysplastic Syndrome Hemoglobin H Disease, Acquired Acquired Alpha-Thalassemia With Myelodysplastic Syndrome Hemoglobin H Disease Acquired Thalassemia, Alpha, Myelodysplasia Syndrome, Somatic
Clark-Baraitser Syndrome	CLABARS Baraitser Syndrome Autosomal Dominant Intellectual Disability 49 Mental Retardation, Autosomal Dominant 49, Formerly Mrd49, Formerly Intellectual Developmental Disorder, Autosomal Dominant 49 Autosomal Dominant Mental Retardation 49 Intellectual Disability, Tall Stature, Obesity, Macrocephaly And Typical Facial Features Mrd49 Progeria Short Stature Pigmented Nevi
Ovarian Clear Cell Carcinoma	Clear-Cell Ovarian Carcinoma
Mediastinum Sarcoma	Sarcoma Of Mediastinum
Cockayne Syndrome	Cockayne'S Syndrome Dwarfism-Retinal Atrophy-Deafness Syndrome Neill-Dingwall Syndrome Progeria-Like Syndrome Progeroid Nanism Cs
Neurilemmomatosis	Schwannomatosis Neurofibromatosis Type 3 Nf3 Neurilemmomatosis Congenital Cutaneous Neurinomatosis Congenital Cutaneous Neurilemmomatosis Multiple Neurilemmomas Multiple Schwannomas Neurilemmomatosis, Congenital Cutaneous Schwannomatosis 1 Neurofibromatosis 3 Mixed Central And Peripheral Neurofibromatosis Nf3 - [Neurofibromatosis Type 3]
Rhabdoid Cancer	Rhabdoid Tumor Malignant Rhabdoid Tumor Malignant Rhabdoid Tumour Rhabdoid Sarcoma Rhabdoid Tumor Predisposition Syndrome 1 Rhabdoid Tumor Predisposition Syndrome 2 Atypical Teratoid Rhabdoid Tumor Brain Tumor, Posterior Fossa, Of Infancy, Familial Atypical Teratoid/Rhabdoid Tumor
Juvenile Type Testicular Granulosa Cell Tumor	Juvenile Granulosa Cell Tumor Juvenile Granulosa Cell Tumour Juvenile Type Granulosa Cell Neoplasm Juvenile Type Granulosa Cell Tumor Juvenile Type Granulosa Cell Tumour Juvenile Type Testicular Granulosa Cell Tumour
Testicular Granulosa Cell Tumor	Granulosa Cell Tumor Of Testis Granulosa Cell Tumour Of Testis Testicular Granulosa Cell Tumour
Floating-Harbor Syndrome	FLHS Fhs Pelletier-Leisti Syndrome Short Stature With Delayed Bone Age, Expressive Language Delay, A Triangular Face With A Prominent Nose And Deep-Set Eyes Leisti-Hollander-Rimoin Syndrome
Paranasal Sinus Cancer	Paranasal Sinus Adenoid Cystic Carcinoma Paranasal Sinus Mucoepidermoid Carcinoma Paranasal Sinus Squamous Cell Carcinoma Paranasal Sinus Neoplasms Adenoid Cystic Carcinoma Of Accessory Sinus Adenoid Cystic Carcinoma Of Paranasal Sinus Epidermoid Carcinoma Of The Paranasal Sinus Mucoepidermoid Carcinoma Of Accessory Sinus Paranasal Sinus Adenocarcinoma Squamous Cell Carcinoma Of Paranasal Sinus Paranasal Sinus Neoplasm Adenocarcinoma Of Accessory Sinus
Clear Cell Adenofibroma	Cystadenofibroma
Helsmoortel-Van Der Aa Syndrome	HVDAS Mrd28 Adnp Syndrome Adnp-Related Syndromic Intellectual Disability-Autism Spectrum Disorder Mental Retardation, Autosomal Dominant 28 Adnp-Related Multiple Congenital Anomalies - Intellectual Disability - Autism Spectrum Disorder Mental Retardation, Autosomal Dominant 28, Formerly Mrd28, Formerly Autosomal Dominant Mental Retardation 28 Adnp-Related Intellectual Disability And Autism Spectrum Disorder Adnp-Related Multiple Congenital Anomalies-Intellectual Disability-Autism Spectrum Disorder
Bacteremia 2	Bacteremia Bacteremia, Susceptibility To, 2 BACTS2 Bacteremia, Susceptibility To Bacteremia, Susceptibility To, Type 2
Oculopharyngeal Muscular Dystrophy	OPMD Muscular Dystrophy, Oculopharyngeal Dystrophy, Oculopharyngeal Muscular Oculopharyngeal Dystrophy Progressive Muscular Dystrophy, Oculopharyngeal Type Muscular Dystrophy Oculopharyngeal Dystrophy, Muscular, Oculopharyngeal
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Posterior Pituitary Gland Neoplasm	Posterior Pituitary Tumor Neoplasm Of The Posterior Pituitary
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Basan Syndrome	Adermatoglyphia With Congenital Facial Milia And Acral Blisters, Digital Contractures, And Nail Abnormalities Ectodermal Dysplasia, Absent Dermatoglyphic Pattern, Changes In Nails, And Simian Crease Baird Syndrome Absence Of Fingerprints-Congenital Milia Syndrome Absence Of Fingerprints Congenital Milia Absence Of Dermatoglyphics Congenital Milia Absence Of Dermatoglyphics-Congenital Milia Syndrome Basan-Baird Syndrome BSNS Adermatoglyphia, Congenital Facial Milia, Acral Blisters, Digital Contractures, Nail Abnormalities
Adrenal Carcinoma	Adrenal Cancer Adrenal Gland Cancer Malignant Neoplasm Of Adrenal Gland Adrenal Gland Neoplasms Carcinoma Of The Adrenal Gland Adrenal Neoplasm Malignant Adrenal Tumor Neoplasm Of Adrenal Gland Tumor Of The Adrenal Gland Adrenal Gland Neoplasm Adrenocortical Carcinoma Adrenal Gland Malignancy Suprarenal Cancer Malignant Neoplasm Of Suprarenal Gland Malignant Neoplasm Of Adrenal Gland, Unspecified Malignant Tumour Of Adrenal Gland Suprarenal Gland Cancer Primary Malignant Neoplasm Of Adrenal Gland
Epithelioid Sarcoma	Epithelioid Cell Sarcoma Sarcoma Epithelioid Sarcoma, Epithelioid
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Epithelioid Malignant Peripheral Nerve Sheath Tumor	Epithelioid Mpnst Malignant Epithelioid Neoplasm Of The Peripheral Nerve Sheath
Small Cell Carcinoma	Small Cell Carcinoma, Intermediate Cell Intermediate Cell Small Cell Carcinoma Small Cell Carcinoma - Intermediate Cell Small Cell Carcinoma Of Lung Carcinoma, Small Cell
Microphthalmia	Microphthalmos Isolated Anophthalmia-Microphthalmia Syndrome Isolated Microphthalmia-Anophthalmia-Coloboma Simple Microphthalmos Clinical Anophthalmia Isolated Anophthalmia - Microphthalmia Isolated Pure Microphthalmia Mac Spectrum Microphthalmia-Anophthalmia-Coloboma Spectrum Primitive Anophthalmia Globe Of Eye Small Small Eyeball Hypoplasia Of Eye Isolated Nanophthalmos Rudimentary Eye Dysplasia Of Eye
Endometrioid Ovary Carcinoma	Endometrioid Carcinoma Of Ovary Endometrioid Carcinoma Ovary Ovarian Endometrioid Carcinoma Malignant Ovarian Endometrioid Tumor Ovarian Endometrioid Tumor
Malignant Teratoma	Immature Teratoma Malignant Extragonadal Teratoma Primary Malignant Extragonadal Teratoma Teratoma, Malignant, Nos Teratoma, Malignant Immature Extragonadal Teratoma
Rett Syndrome	Atypical Rett Syndrome RTT Rett Disorder Rts Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use Rett Syndrome, Preserved Speech Variant Rett Syndrome, Atypical Rett'S Disorder Rett Syndrome Variant Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome Cerebroatrophic Hyperammonemia Rett Like Syndrome Rett'S Syndrome Atypical Rtt Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Rett Syndrome Preserved Speech Variant Rett Syndrome Zappella Variant Rett Syndrome, Zappella Variant
Charge Syndrome	Charge Association Hall-Hittner Syndrome Charge Association--Coloboma, Heart Anomaly, Choanal Atresia, Retardation, Genital And Ear Anomalies Hhs Coloboma, Heart Anomaly, Choanal Atresia, Restriction Of Growth And Development, Genital And Ear Anomalies Coloboma-Heart Defects-Atresia Choanae-Retardation Of Growth And Development-Genitourinary Problems-Ear Abnormalities Syndrome CHARGES
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Rhabdomyosarcoma
Cartilage-Hair Hypoplasia	Metaphyseal Chondrodysplasia, Mckusick Type CHH Mckusick Type Metaphyseal Chondrodysplasia Metaphyseal Dysplasia Without Hypotrichosis Cartilage Hair Hypoplasia Like Syndrome Metaphyseal Chondrodysplasia Mckusick Type Chhv Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency Cartilage-Hair Syndrome Mckusick'S Metaphyseal Chondrodysplasia Syndrome Metaphyseal Chondrodysplasia, Recessive Type Autosomal Recessive Metaphyseal Chondrodysplasia
Clear Cell Meningioma
Alpha-Thalassemia	Alpha Thalassemia Alpha Thalassaemia Alpha Plus Thalassemia Thalassemia, Alpha- Thalassemias, Alpha- A-Thalassemia Α-Thalassemia A-THAL Thalassemia Alpha Thalassaemia Syndrome
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome	Icf Syndrome Immunodeficiency Syndrome, Variable Ciid Centromeric Instability, Immunodeficiency Syndrome Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16 Icf
Childhood Medulloblastoma	Medulloblastoma, Childhood Pediatric Medulloblastoma Medulloblastoma Childhood
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Hyperoxaluria, Primary, Type I	Primary Hyperoxaluria Type 1 HP1 Glycolic Aciduria Alanine-Glyoxylate Aminotransferase Deficiency Hepatic Agt Deficiency Oxalosis I Primary Hyperoxaluria, Type I Serine:Pyruvate Aminotransferase Deficiency Hyperoxaluria, Primary, Type 1 Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency Serine Pyruvate Aminotransferase Deficiency Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency Oxalosis 1 Hyperoxaluria Primary 1 Hyperoxaluria Primary Type I Ph1 Primary Hyperoxaluria Type I Oxalosis Type 1 2-Oxoglutarate Glyoxylate Carboligase Deficiency
Kabuki Syndrome 1	Kabuki Syndrome Niikawa-Kuroki Syndrome Kabuki Make-Up Syndrome Kms KABUK1 Kabuki Make Up Syndrome Nks Kabuki Makeup Syndrome Kabuki Syndrome, Type 1
Cockayne Syndrome B	Cockayne Syndrome Type 2 Cockayne Syndrome, Type B Cockayne Syndrome Type Ii CSB Cockayne Syndrome 2 Cockayne Syndrome Type B Ckn2 Cockayne Syndrome, Type Ii
Primary Hyperoxaluria	Hyperoxaluria Hyperoxaluria, Primary Oxalosis Primary Oxalosis Congenital Oxaluria D-Glycerate Dehydrogenase Deficiency Glyceric Aciduria Glycolic Aciduria Hepatic Agt Deficiency Oxaluria, Primary Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency Primary Oxaluria Hyperoxaluria Primary Primary Hyperoxaluria Type 2 Primary Hyperoxaluria, Type I
Infratentorial Cancer	Infratentorial Neoplasms Brain Neoplasm, Infratentorial Malignant Infratentorial Tumors
Chromosome 16p13.3 Deletion Syndrome, Proximal	Rubinstein-Taybi Syndrome Broad Thumb-Hallux Syndrome Chromosome 16p13.3 Deletion Syndrome Rubinstein-Taybi Syndrome Due To 16p13.3 Microdeletion Rubinstein Syndrome Broad Thumbs-Halluces Syndrome Rsts Rubinstein-Taybi Deletion Syndrome Rsts Deletion Syndrome Proximal Chromosome 16p13.3 Deletion Syndrome 16p13.3 Deletion Syndrome Broad Thumbs And Great Toes, Characteristic Facies, And Intellectual Disability Rts
Papillary Adenofibroma
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Sarcoma, Synovial	Synovial Sarcoma Synovialosarcoma Synovial Cell Sarcoma Sarcoma Synovial
Developmental And Epileptic Encephalopathy 14	Malignant Migrating Partial Seizures Of Infancy Eiee14 Epilepsy Of Infancy With Migrating Focal Seizures Mmpsi DEE14 Epileptic Encephalopathy, Early Infantile, 14 Early Infantile Epileptic Encephalopathy 14 Malignant Migrating Partial Epilepsy Of Infancy Migrating Partial Epilepsy Of Infancy Migrating Partial Seizures Of Infancy Mmpei Mpei Mpsi Malignant Migrating Focal Seizures Of Infancy Migrating Partial Seizures In Infancy Developmental And Epileptic Encephalopathy, 14 Encephalopathy, Epileptic, Early Infantile, Type 14
Basal Cell Nevus Syndrome	Nevoid Basal Cell Carcinoma Syndrome Gorlin Syndrome Nbccs BCNS Gorlin-Goltz Syndrome Multiple Basal Cell Nevi, Odontogenic Keratocysts, And Skeletal Anomalies Cerebral Gigantism Jaw Cysts Cramer Niederdellmann Syndrome Gorlin Syndrome Or Gorlin-Goltz Syndrome Naevoid Basal Cell Carcinoma Syndrome
Patent Ductus Arteriosus 1	Patent Ductus Arteriosus PDA1 Pda Ductus Arteriosus, Patent Patent Ductus Arteriosus, Susceptibility To Patent Ductus Botalli Patency Of The Ductus Arteriosus Patent Ductus Arteriosus Familial Ductus Arteriosus Patent Patent Ductus Arteriosus - Persisting Type
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc
Aortic Aneurysm, Familial Thoracic 1	Thoracic Aortic Aneurysm Annuloaortic Ectasia Familial Thoracic Aortic Aneurysm And Aortic Dissection Familial Aortic Dissection Familial Taad Familial Thoracic Aortic Aneurysm Congenital Aneurysm Of Ascending Aorta Familial Aortic Aneurysm Familial Thoracic Aortic Aneurysm And Dissection Aortic Aneurysm, Thoracic AAT1 Faa1 Aortic Dissection, Familial Aortic Aneurysm, Familial Thoracic Aneurysm, Thoracic Aortic Faa Ftaad Taa Taad Cystic Medial Necrosis Of Aorta Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection Aortic Aneurysm Thoracic Familial Aortic Aneurysms Aneurysm, Aortic, Thoracic, Familial, Type 1 Aneurysm Of Thoracic Aorta Intrathoracic Aneurysm Thoracic Aorta Aneurysm Thoracic Aortic Aneurysm Without Rupture Thoracic Aneurysm Thorax Arterial Aneurysm Thoracic Artery Aneurysm Thoracic Arterial Aneurysm Thorax Aneurysm Thorax Aortic Aneurysm Dissection Of Thoracic Aorta
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-159607	PRT3789	Degrader	98.08%	Phase 2
HY-13030	(+)-JQ-1	Ligand	99.91%	Phase 1

Pre-clinical Phase

Bioactive Molecules (37)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-145388	AU-15330	Degrader	99.89%	Unkown
HY-128359	ACBI1	Degrader	99.92%	Unkown
HY-44012	SMARCA-BD ligand 1 for PROTAC	Ligand	99.07%	Unkown
HY-44012B	SMARCA-BD ligand 1 for PROTAC hydrochloride	Ligand	99.24%	Unkown
HY-44012A	SMARCA-BD ligand 1 for PROTAC dihydrochloride	Ligand	98.08%	Unkown
HY-46618	SMARCA2/4-ligand-8	Ligand	99.66%	Unkown
HY-148381	A947	Degrader	/	Unkown
HY-185075	FHD-909	Inhibitor	/	Unkown
HY-159453	PROTAC SMARCA2/4 degrader-2	Degrader	/	Unkown
HY-162813	PROTAC SMARCA2/4 degrader-25	Degrader	/	Unkown
HY-161885	SMARCA2/4-IN-4	Inhibitor	/	Unkown
HY-162745	PROTAC SMARCA2/4 degrader-42	Degrader	/	Unkown
HY-159461	PROTAC SMARCA2/4 degrader-9	Degrader	/	Unkown
HY-169280	PXR Ligand 2		/	Unkown
HY-159460	PROTAC SMARCA2/4 degrader-8	Degrader	/	Unkown
HY-162748	PROTAC SMARCA2/4 degrader-30	Degrader	/	Unkown
HY-162815	PROTAC SMARCA2/4 degrader-26	Degrader	/	Unkown
HY-163864	PROTAC SMARCA2/4 degrader-11	Degrader	/	Unkown
HY-171765	SMARCA2/4-ligand-6	Ligand	/	Unkown
HY-162835	PROTAC SMARCA2/4 degrader-28	Degrader	/	Unkown
HY-178225	PROTAC SMARCA2/4 degrader-39	Degrader	/	Unkown
HY-170354	SMARCA2/4-ligand-4	Ligand	/	Unkown
HY-159458	PROTAC SMARCA2/4 degrader-7	Degrader	/	Unkown
HY-170817	SMI-1074	Inhibitor	/	Unkown
HY-159457	PROTAC SMARCA2/4 degrader-6	Degrader	/	Unkown
HY-153425	PROTAC SMARCA2/4 degrader-41	Degrader	/	Unkown
HY-159454	PROTAC SMARCA2/4 degrader-3	Degrader	/	Unkown
HY-162814	SMARCA2/4-ligand-3	Ligand	/	Unkown
HY-163949	SMARCA2/4-IN-3	Inhibitor	/	Unkown
HY-162834	PROTAC SMARCA2/4 degrader-27	Degrader	/	Unkown
HY-159459	PROTAC SMARCA2/4 degrader-32	Degrader	/	Unkown
HY-168252	BRM/BRG1 ligand 3	Ligand	/	Unkown
HY-163865	PROTAC SMARCA2 degrader-13	Degrader	/	Unkown
HY-168248	BRM/BRG1 ligand 2	Ligand	/	Unkown
HY-159472	SMARCA2/4-ligand-1	Inhibitor	/	Unkown
HY-W539427	BRM/BRG1 ligand 1	Ligand	/	Unkown
HY-172446	SMARCA2/4-ligand-5		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SMARCA4	RGD	RGD:621728
Canis familiaris	SMARCA4	VGNC	VGNC:46530
Macaca mulatta	SMARCA4	VGNC	VGNC:77648
Felis catus	SMARCA4	VGNC	VGNC:65464
Bos taurus	SMARCA4	VGNC	VGNC:34987
Mus musculus	SMARCA4	MGD	MGI:88192
Others	SMARCA4	NCBI