Map2 - microtubule-associated protein 2 Gene

Also Known as MAP-2; Mtap2; Mtap-2; repro4; G1-397-34

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17756

Summary

Enables microtubule binding activity. Involved in microtubule Cytoskeleton organization; negative regulation of axon extension; and regulation of protein localization. Acts upstream of or within several processes, including establishment of cell polarity; microtubule bundle formation; and neuron projection development. Located in several cellular components, including axon; dendrite; and proximal neuron projection. Is expressed in several structures, including back skin; central nervous system; peripheral nervous system ganglion; retina; and trigeminal nerve. Orthologous to human MAP2 (microtubule associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Map2 Products (3)

mRNA Protein Name
NM_001039934.1 NP_001035023.1 microtubule-associated protein 2 isoform 1
NM_001310634.1 NP_001297563.1 microtubule-associated protein 2 isoform 3
NM_008632.2 NP_032658.2 microtubule-associated protein 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables microtubule binding IDA
IDA: Inferred from direct assay
17360631 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17360631 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within axonogenesis IGI
IGI: Inferred from genetic interaction
11891784 MGI
acts upstream of or within axonogenesis IMP
IMP: Inferred from mutant phenotype
11891784 MGI
acts upstream of or within dendrite development IMP
IMP: Inferred from mutant phenotype
11581286 MGI
acts upstream of or within establishment of cell polarity IMP
IMP: Inferred from mutant phenotype
20600662 MGI
acts upstream of or within microtubule bundle formation IMP
IMP: Inferred from mutant phenotype
11581286 MGI
involved in microtubule cytoskeleton organization IDA
IDA: Inferred from direct assay
10542369 MGI
involved in negative regulation of axon extension IMP
IMP: Inferred from mutant phenotype
28426968 MGI
involved in regulation of protein localization IMP
IMP: Inferred from mutant phenotype
28426968 MGI
Cellular Component GO Annotation Evidence References Source
located in CA3 pyramidal cell dendrite IDA
IDA: Inferred from direct assay
18165320 MGI
located in apical dendrite IDA
IDA: Inferred from direct assay
23936366 MGI
located in axon hillock IDA
IDA: Inferred from direct assay
28426968 MGI
located in axon initial segment IDA
IDA: Inferred from direct assay
28426968 MGI
is active in cell body IDA
IDA: Inferred from direct assay
17634368 MGI
located in cell body IDA
IDA: Inferred from direct assay
15255972 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
15656993 MGI
is active in dendrite IDA
IDA: Inferred from direct assay
17634368 MGI
located in dendrite IDA
IDA: Inferred from direct assay
3147150 MGI
located in dendritic shaft IDA
IDA: Inferred from direct assay
15996550 MGI
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
16892058 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
18359573 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
12074840 MGI
located in nuclear periphery IDA
IDA: Inferred from direct assay
11834298 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
17114649 MGI
located in proximal neuron projection IDA
IDA: Inferred from direct assay
28426968 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

microtubule-associated protein 2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-107116 MAP4343 99.67% Phase 2

Pre-clinical Phase

Bioactive Molecules (37)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136848 SM1-71 Inhibitor 96.09% Unkown
HY-159190 HRX-0233 Inhibitor 98.92% Unkown
HY-171178 DK2403 98.24% Unkown
HY-D2415 BODIPY-FL staurosporine 95.4% Unkown
HY-RS08350 METAP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16235 Map2k4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-107116S MAP4343-d4 / Unkown
HY-163880 EGFR-IN-119 Inhibitor / Unkown
HY-168857 GSK-3β inhibitor 24 / Unkown
HY-181926 COX-2/HDAC6-IN-1 / Unkown
HY-184145 AKT1-IN-13 / Unkown
HY-E70842 MAP2K1 L115P Recombinant Human Active Protein Kinase / Unkown
HY-E70843 MAP2K1 P124L Recombinant Human Active Protein Kinase / Unkown
HY-E70844 MAP2K2 Recombinant Human Active Protein Kinase / Unkown
HY-P3894 P34cdc2 Kinase Fragment Modulator / Unkown
HY-RS08032 MAP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08033 MAP2K1 Human Pre-designed siRNA Set A / Unkown
HY-RS08034 Map2k1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08035 Map2k1 Rat Pre-designed siRNA Set A / Unkown
HY-RS08036 MAP2K2 Human Pre-designed siRNA Set A / Unkown
HY-RS08037 Map2k2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08038 Map2k2 Rat Pre-designed siRNA Set A / Unkown
HY-RS08039 MAP2K3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08040 MAP2K4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08041 MAP2K5 Human Pre-designed siRNA Set A / Unkown
HY-RS08042 Map2k5 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08043 Map2k5 Rat Pre-designed siRNA Set A / Unkown
HY-RS08044 MAP2K6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08045 MAP2K7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08160 MASP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17292 Map2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17782 Map2k6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18959 Neu1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19790 Map2k7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23747 Map2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24249 Map2k6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26286 Map2k7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map2 NCBI NCBI:4133