MAP2 - microtubule associated protein 2 Gene

Also Known as MAP-2; MAP2A; MAP2B; MAP2C

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4133

About MAP2

Cytogenetic location: 2q34 Genomic coordinates (GRCh38): 2:209,424,047-209,734,112 (from NCBI)

This gene has 19 transcripts (splice variants), 274 orthologues and 1 paralogue. Biased expression in brain (RPKM 82.4), thyroid (RPKM 4.7) and 1 other tissue.

Summary

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010]

MAP2 Products (58)

mRNA	Protein	Name
NM_001039538.2	NP_001034627.1	microtubule-associated protein 2 isoform 5
NM_001363910.2	NP_001350839.1	microtubule-associated protein 2 isoform 6
NM_001363911.2	NP_001350840.1	microtubule-associated protein 2 isoform 6
NM_001363913.2	NP_001350842.1	microtubule-associated protein 2 isoform 2
NM_001375474.1	NP_001362403.1	microtubule-associated protein 2 isoform 24
NM_001375493.1	NP_001362422.1	microtubule-associated protein 2 isoform 2
NM_001375494.1	NP_001362423.1	microtubule-associated protein 2 isoform 30
NM_001375495.1	NP_001362424.1	microtubule-associated protein 2 isoform 20
NM_001375496.1	NP_001362425.1	microtubule-associated protein 2 isoform 25
NM_001375497.1	NP_001362426.1	microtubule-associated protein 2 isoform 27
NM_001375498.1	NP_001362427.1	microtubule-associated protein 2 isoform 19
NM_001375499.1	NP_001362428.1	microtubule-associated protein 2 isoform 4
NM_001375500.1	NP_001362429.1	microtubule-associated protein 2 isoform 18
NM_001375501.1	NP_001362430.1	microtubule-associated protein 2 isoform 8
NM_001375502.1	NP_001362431.1	microtubule-associated protein 2 isoform 13
NM_001375503.1	NP_001362432.1	microtubule-associated protein 2 isoform 11
NM_001375504.1	NP_001362433.1	microtubule-associated protein 2 isoform 7
NM_001375505.1	NP_001362434.1	microtubule-associated protein 2 isoform 1
NM_001375506.1	NP_001362435.1	microtubule-associated protein 2 isoform 12
NM_001375507.1	NP_001362436.1	microtubule-associated protein 2 isoform 14
NM_001375508.1	NP_001362437.1	microtubule-associated protein 2 isoform 4
NM_001375509.1	NP_001362438.1	microtubule-associated protein 2 isoform 23
NM_001375510.1	NP_001362439.1	microtubule-associated protein 2 isoform 20
NM_001375526.1	NP_001362455.1	microtubule-associated protein 2 isoform 1
NM_001375527.1	NP_001362456.1	microtubule-associated protein 2 isoform 12
NM_001375528.1	NP_001362457.1	microtubule-associated protein 2 isoform 6
NM_001375529.1	NP_001362458.1	microtubule-associated protein 2 isoform 27
NM_001375530.1	NP_001362459.1	microtubule-associated protein 2 isoform 36
NM_001375531.1	NP_001362460.1	microtubule-associated protein 2 isoform 9
NM_001375532.1	NP_001362461.1	microtubule-associated protein 2 isoform 36
NM_001375533.1	NP_001362462.1	microtubule-associated protein 2 isoform 27
NM_001375534.1	NP_001362463.1	microtubule-associated protein 2 isoform 1
NM_001375535.1	NP_001362464.1	microtubule-associated protein 2 isoform 22
NM_001375536.1	NP_001362465.1	microtubule-associated protein 2 isoform 20
NM_001375537.1	NP_001362466.1	microtubule-associated protein 2 isoform 8
NM_001375538.1	NP_001362467.1	microtubule-associated protein 2 isoform 21
NM_001375539.1	NP_001362468.1	microtubule-associated protein 2 isoform 10
NM_001375540.1	NP_001362469.1	microtubule-associated protein 2 isoform 35
NM_001375541.1	NP_001362470.1	microtubule-associated protein 2 isoform 26
NM_001375542.1	NP_001362471.1	microtubule-associated protein 2 isoform 28
NM_001375543.1	NP_001362472.1	microtubule-associated protein 2 isoform 31
NM_001375544.1	NP_001362473.1	microtubule-associated protein 2 isoform 13
NM_001375545.1	NP_001362474.1	microtubule-associated protein 2 isoform 14
NM_001375546.1	NP_001362475.1	microtubule-associated protein 2 isoform 32
NM_001375548.1	NP_001362477.1	microtubule-associated protein 2 isoform 33
NM_001375551.1	NP_001362480.1	microtubule-associated protein 2 isoform 16
NM_001375552.1	NP_001362481.1	microtubule-associated protein 2 isoform 16
NM_001375553.1	NP_001362482.1	microtubule-associated protein 2 isoform 29
NM_001375554.1	NP_001362483.1	microtubule-associated protein 2 isoform 29
NM_001375555.1	NP_001362484.1	microtubule-associated protein 2 isoform 15
NM_001375556.1	NP_001362485.1	microtubule-associated protein 2 isoform 16
NM_001375557.1	NP_001362486.1	microtubule-associated protein 2 isoform 16
NM_001375558.1	NP_001362487.1	microtubule-associated protein 2 isoform 17
NM_001375559.1	NP_001362488.1	microtubule-associated protein 2 isoform 34
NM_001375583.1	NP_001362512.1	microtubule-associated protein 2 isoform 2
NM_002374.4	NP_002365.3	microtubule-associated protein 2 isoform 1
NM_031845.3	NP_114033.2	microtubule-associated protein 2 isoform 2
NM_031847.3	NP_114035.2	microtubule-associated protein 2 isoform 4

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables dystroglycan binding	IPI IPI: Inferred from physical interaction	18341635	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20195357	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in central nervous system neuron development	IEP IEP: Inferred from expression pattern	20846339	GOA
involved in dendrite morphogenesis	IEP IEP: Inferred from expression pattern	20846339	GOA
involved in neuron projection development	IEP IEP: Inferred from expression pattern	20846339	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP2 Protein Structure

MAP2_projctn

Tubulin-binding

0
300
600
900
1200
1500
1827 a.a.

Protein Preferred Names	Protein Names
microtubule-associated protein 2

MAP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MAP2	P11137	CBFB	Homo sapiens	Q13951	Display Tech	20195357

Cross: Cross-species interaction Intra: Intraspecies interaction

MAP2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81053	MAP2 Antibody	WB, ICC/IF, IHC-P	Human, Mouse, Rat
HY-P86134	MAP2 Antibody (YA5826)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Central Neurocytoma	Neurocytoma Neurolipocytoma Neurocytoma Central
Olivopontocerebellar Atrophy	Thomas Syndrome Olivopontocerebellar Atrophies Dejerine-Thomas Syndrome Thomas' Syndrome Wadia-Swami Syndrome Opca Potter Sequence-Cleft Lip/Palate-Cardiopathy Syndrome Spinocerebellar Ataxia Type 2
Ganglioglioma	Childhood Ganglioglioma Adult Ganglioglioma Cns Ganglioglioma Mixed Cell Tumors Containing Both Neural Ganglionic Cells And Neural Glial Cell Components
Merkel Cell Carcinoma	Trabecular Adenocarcinoma Cutaneous Neuroendocrine Carcinoma Trabecular Carcinoma Carcinoma, Merkel Cell Merkel Cell Cancer Merkle Tumors Mcc Carcinoma Merkel Cell
Striatonigral Degeneration
Ischemia	Acute Coronary Syndrome
Transient Cerebral Ischemia	Transient Ischemic Attack Transient Ischemic Attacks Tia Tia - Transient Ischaemic Attack Transient Cerebral Ischaemia Ischemic Attack, Transient Intermittent Cerebral Ischemia Tia - [Transient Ischaemic Attack] Intermittent Cerebral Ischaemia Transient Cerebral Ischaemic Attack, Unspecified, Course Of Resolution Unspecified
Scrapie
Rett Syndrome	Atypical Rett Syndrome RTT Rett Disorder Rts Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use Rett Syndrome, Preserved Speech Variant Rett Syndrome, Atypical Rett'S Disorder Rett Syndrome Variant Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome Cerebroatrophic Hyperammonemia Rett Like Syndrome Rett'S Syndrome Atypical Rtt Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Rett Syndrome Preserved Speech Variant Rett Syndrome Zappella Variant Rett Syndrome, Zappella Variant
Human Monocytic Ehrlichiosis	Ehrlichiosis Chafeensis Hme Human Ehrlichial Infection, Human Monocytic Type
Teratoma	Teratomas
Chiari Malformation
Occlusion Precerebral Artery	Occlusion And Stenosis Of Multiple And Bilateral Precerebral Arteries Occlusion And Stenosis Of Precerebral Artery
Multiple System Atrophy 1	Multiple System Atrophy Shy-Drager Syndrome Msa MSA1 Multiple System Atrophy 1, Susceptibility To Sporadic Olivopontocerebellar Atrophy Multisystem Atrophy Msa1, Susceptibility To Multiple System Atrophy, Susceptibility To Opca Progressive Autonomic Failure With Multiple System Atrophy Sds
Cerebellar Liponeurocytoma	Lipomatous Medulloblastoma Central Neurocytoma
Dementia	Dementias Presenile Dementia Alzheimer Type Dementia Alzheimer Sclerosis Alzheimer Disease Dementia Alzheimer Dementia Primary Degenerative Alzheimer Type Dementia End Stage Alzheimer'S Dementia Alzheimer'S Type Atypical Dementia Alzheimer Type Presenile Dementia Early Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 2 Dementia In Alzheimer Disease With Early Onset Early Onset Alzheimer Type Dementia, Uncomplicated Primary Degenerative Alzheimer Type Dementia, Early Onset Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated Alzheimer Disease Dementia With Early Onset Presenile Sclerosis Presenile Brain Sclerosis Presenile Alzheimer Brain Sclerosis Late Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 1 Dementia In Alzheimer Disease With Late Onset Primary Degenerative Alzheimer Type Dementia, Late Onset Sdat - [Senile Dementia, Alzheimer Type] Alzheimer Disease Dementia With Late Onset Late Onset Alzheimer Brain Sclerosis Senile Alzheimer Brain Disease Senile Alzheimer Brain Sclerosis Senile Primary Degenerative Alzheimer Type Dementia Senile Dementia Of The Alzheimer Type Arteriosclerotic Dementia Strategic-Infarct Dementia Post Stroke Dementia Vascular Cognitive Impairment Vascular Dementia Dementia Of The Lewy Body Type Dementia With Lewy Bodies Sdlt - [Senile Dementia Of The Lewy Body Type] Senile Dementia Of The Lewy Body Type Alcohol-Related Dementia Alcoholic Dementia Nos Alcohol-Induced Dementia Alcoholic Brain Syndrome Chronic Alcoholic Brain Syndrome Alcohol Dementia Late Onset Alcoholic Psychosis Residual And Late-Onset Alcohol-Induced Psychotic Disorder Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder Late-Onset Psychoactive Substance-Induced Psychotic Disorder Inhalant Dementia Volatile Solvents Dementia Dementia In Paralysis Agitans Pdd - [Parkinson Disease Dementia] Dementia Syndrome Of Parkinson Disease Dementia In Parkinson Disease Parkinson Related Dementia Dementia In Huntington Chorea Hiv - [Human Immunodeficiency Virus] Dementia Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex Aids Related Dementia Dementia Due To Niacin Deficiency
Carotid Artery Occlusion	Occlusion And Stenosis Of Carotid Artery
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Huntington Disease	Huntington'S Disease Huntington Chorea Huntington'S Chorea HD Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Demyelinating Disease	Demyelinating Diseases Demyelinating Disorder
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Sudden Infant Death Syndrome	SIDS Sudden Infant Death Syndrome, Susceptibility To Cot Death Crib Death Sudden Death Of Nonspecific Cause In Infancy Sudden Infant Death Death, Sudden, Syndrome, Infant
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Toxic Encephalopathy	Neurotoxicity Neurotoxicity Syndromes Neurotoxicity Syndrome Encephalopathy, Toxic
Stroke, Ischemic	Cerebral Infarction Stroke Ischemic Stroke Cerebrovascular Accident Cerebral Infarction, Susceptibility To Stroke, Ischemic, Susceptibility To Cerebral Infarct Ischemic Stroke, Susceptibility To Stroke, Susceptibility To Cva - Cerebral Infarction ISCHSTR Ischemic Cerebrovascular Accident
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Pick Disease Of Brain	Pick Disease Pick'S Disease Pick Disease Of The Brain Lobar Atrophy Of Brain Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions Behavioral Variant Of Frontotemporal Dementia Dementia In Pick'S Disease Lobar Atrophy Of The Brain Bvftd Bv-Ftd PIDB Picks Disease
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-107116	MAP4343		99.67%	Phase 2

Pre-clinical Phase

Bioactive Molecules (37)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136848	SM1-71	Inhibitor	96.09%	Unkown
HY-159190	HRX-0233	Inhibitor	98.92%	Unkown
HY-171178	DK2403		98.24%	Unkown
HY-D2415	BODIPY-FL staurosporine		95.4%	Unkown
HY-RS08350	METAP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16235	Map2k4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-107116S	MAP4343-d4		/	Unkown
HY-163880	EGFR-IN-119	Inhibitor	/	Unkown
HY-168857	GSK-3β inhibitor 24		/	Unkown
HY-181926	COX-2/HDAC6-IN-1		/	Unkown
HY-184145	AKT1-IN-13		/	Unkown
HY-E70842	MAP2K1 L115P Recombinant Human Active Protein Kinase		/	Unkown
HY-E70843	MAP2K1 P124L Recombinant Human Active Protein Kinase		/	Unkown
HY-E70844	MAP2K2 Recombinant Human Active Protein Kinase		/	Unkown
HY-P3894	P34cdc2 Kinase Fragment	Modulator	/	Unkown
HY-RS08032	MAP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08033	MAP2K1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS08034	Map2k1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS08035	Map2k1 Rat Pre-designed siRNA Set A		/	Unkown
HY-RS08036	MAP2K2 Human Pre-designed siRNA Set A		/	Unkown
HY-RS08037	Map2k2 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS08038	Map2k2 Rat Pre-designed siRNA Set A		/	Unkown
HY-RS08039	MAP2K3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08040	MAP2K4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08041	MAP2K5 Human Pre-designed siRNA Set A		/	Unkown
HY-RS08042	Map2k5 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS08043	Map2k5 Rat Pre-designed siRNA Set A		/	Unkown
HY-RS08044	MAP2K6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08045	MAP2K7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08160	MASP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17292	Map2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17782	Map2k6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18959	Neu1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19790	Map2k7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23747	Map2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24249	Map2k6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26286	Map2k7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MAP2	VGNC	VGNC:42959
Mus musculus	MAP2	MGD	MGI:97175
Bos taurus	MAP2	VGNC	VGNC:31182
Macaca mulatta	MAP2	VGNC	VGNC:74491
Rattus norvegicus	MAP2	RGD	RGD:3044
Felis catus	MAP2	VGNC	VGNC:68153
Others	MAP2	NCBI