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Pdgfra - platelet derived growth factor receptor, alpha polypeptide Gene

Also Known as CD140a; Pdgfr-2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18595

About Pdgfra

Chromosome 5: 75,312,953-75,358,876 forward strand.GRCm39:CM000998.3

This gene has 9 transcripts (splice variants), 204 orthologues, 53 paralogues and is associated with 99 phenotypes. Broad expression in limb E14.5 (RPKM 29.6), lung adult (RPKM 2.2) and 19 other tissues.

Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins. Binding of platelet-derived growth factor protein ligands to this receptor triggers receptor dimerization and autophosphorylation, resulting in the activation of several downstream signaling pathways. Signaling through the encoded receptor plays a role in gastrulation and the development of nearly all organ systems. Mice lacking a functional copy of this gene reportedly exhibit defects in lung, skeleton, testis and the central nervous system, and die soon after birth. Alternative splicing and intronic polyadenylation of gene transcripts have been implicated in muscle regeneration and fibrosis in adult mice. [provided by RefSeq, Jan 2017]

Pdgfra Products (4)

mRNA	Protein	Name
NM_011058.3	NP_035188.2	platelet-derived growth factor receptor alpha isoform 1 precursor
NM_001347719.1	NP_001334648.1	platelet-derived growth factor receptor alpha isoform 2 precursor
NM_001083316.2	NP_001076785.1	platelet-derived growth factor receptor alpha isoform 1 precursor
NM_001347718.1	NP_001334647.1	platelet-derived growth factor receptor alpha isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables platelet-derived growth factor alpha-receptor activity	IDA IDA: Inferred from direct assay	20110689	MGI
enables platelet-derived growth factor binding	IDA IDA: Inferred from direct assay	15372073	MGI
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	23160237	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within Leydig cell differentiation	IMP IMP: Inferred from mutant phenotype	19056881	MGI
acts upstream of or within adrenal gland development	IGI IGI: Inferred from genetic interaction	19056881	MGI
acts upstream of or within anatomical structure morphogenesis	IMP IMP: Inferred from mutant phenotype	15543606	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	10806482	MGI
involved in cardiac myofibril assembly	IGI IGI: Inferred from genetic interaction	11239463	MGI
involved in cell chemotaxis	IMP IMP: Inferred from mutant phenotype	20110689	MGI
involved in cell migration	IMP IMP: Inferred from mutant phenotype	20110689	MGI
acts upstream of or within cellular response to amino acid stimulus	IDA IDA: Inferred from direct assay	20548288	MGI
involved in embryonic cranial skeleton morphogenesis	IMP IMP: Inferred from mutant phenotype	9226440	MGI
involved in embryonic digestive tract morphogenesis	IMP IMP: Inferred from mutant phenotype	10903171	MGI
acts upstream of or within estrogen metabolic process	IGI IGI: Inferred from genetic interaction	19056881	MGI
acts upstream of or within extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	15543606	MGI
acts upstream of or within face morphogenesis	IMP IMP: Inferred from mutant phenotype	17143286	MGI
acts upstream of or within female gonad development	IGI IGI: Inferred from genetic interaction	19056881	MGI
acts upstream of or within hematopoietic progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	24029230	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	10331973	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	11803579	MGI
acts upstream of or within luteinization	IGI IGI: Inferred from genetic interaction	19056881	MGI
acts upstream of or within luteinization	IMP IMP: Inferred from mutant phenotype	19056881	MGI
acts upstream of or within male genitalia development	IMP IMP: Inferred from mutant phenotype	12651897	MGI
involved in metanephric glomerular capillary formation	IGI IGI: Inferred from genetic interaction	11239463	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IMP IMP: Inferred from mutant phenotype	15543606	MGI
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	20110689	MGI
acts upstream of or within platelet-derived growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17143286	MGI
involved in platelet-derived growth factor receptor-alpha signaling pathway	IDA IDA: Inferred from direct assay	20110689	MGI
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	20110689	MGI
involved in retina vasculature development in camera-type eye	IGI IGI: Inferred from genetic interaction	11239463	MGI
acts upstream of or within roof of mouth development	IMP IMP: Inferred from mutant phenotype	17143286	MGI
acts upstream of or within signal transduction involved in regulation of gene expression	IDA IDA: Inferred from direct assay	18462699	MGI
acts upstream of or within skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	17143286	MGI
acts upstream of or within white fat cell differentiation	IMP IMP: Inferred from mutant phenotype	28049691	MGI
involved in wound healing	IMP IMP: Inferred from mutant phenotype	20110689	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	29237719	MGI
located in cell surface	IDA IDA: Inferred from direct assay	22265737	MGI
located in cilium	IDA IDA: Inferred from direct assay	29237719	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	22027834	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	17350578	MGI
located in microvillus	IDA IDA: Inferred from direct assay	23266329	MGI
located in nucleus	IDA IDA: Inferred from direct assay	21146513	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pdgfra Protein Structure

Ig_3

Ig4_PDGFR

PTKc_PDGFR_alpha

0
200
400
600
800
1000
1089 a.a.

Protein Preferred Names	Protein Names
platelet-derived growth factor receptor alpha	Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha) CD140 antigen-like family member A PDGF alpha chain PDGF-R-alpha PDGFR-alpha alpha-type platelet-derived growth factor receptor

Recombinant Pdgfra Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72496	PDGFRA Protein, Mouse (HEK293, His)	P26618 (L25-E524)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74645	PDGFRA Protein, Mouse (HEK293, Fc)	NP_001334647.1 (L25-E524)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13001	Quizartinib		99.08%	Yes
HY-101561	Avapritinib	Inhibitor	99.85%	Yes
HY-112306	Ripretinib		98.90%	Yes
HY-14217	Quizartinib dihydrochloride		99.81%	Unkown
HY-13001R	Quizartinib (Standard)		/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-132166	Velzatinib	Inhibitor	99.40%	Phase 3

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10254	PDGFRA Human Pre-designed siRNA Set A		/	Unkown
HY-108444	(Z)-FeCP-oxindole	Inhibitor	99.62%	Unkown
HY-13001S	Quizartinib-d8		/	Unkown
HY-108444A	(E)-FeCP-oxindole	Inhibitor	/	Unkown
HY-149510	MET/PDGFRA-IN-1		/	Unkown
HY-149511	MET/PDGFRA-IN-2		/	Unkown
HY-170911	KIT/PDGFRA-IN-1	Inhibitor	/	Unkown
HY-173124	CDK2/FLT4/PDGFRA-IN-1		/	Unkown
HY-175212	PDGFRA-IN-1	Inhibitor	/	Unkown
HY-181108	GSK190937	Inhibitor	/	Unkown
HY-181587	PDGFRA/CAIX/XII-IN-1		98.10%	Unkown
HY-181886	AK177		/	Unkown
HY-RS10255	Pdgfra Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS10256	PDGFRA Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174549	Human PDGFRA mRNA		/	Unkown
HY-W754911	Avapritinib-d3	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pdgfra	NCBI	NCBI:5156