2. Gene
  3. Pik3ca - phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Gene

Pik3ca - phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as p110; caPI3K; p110alpha; 6330412C24Rik

Gene ID: 18706 | Gene type: protein coding

About Pik3ca

Chromosome 3: 32,451,820-32,522,635 forward strand.GRCm39:CM000996.3

This gene has 4 transcripts (splice variants), 275 orthologues, 9 paralogues and is associated with 42 phenotypes. Ubiquitous expression in bladder adult (RPKM 6.2), cerebellum adult (RPKM 5.7) and 26 other tissues.

Summary

Enables 1-phosphatidylinositol-3-kinase activity; Insulin Receptor substrate binding activity; and protein kinase activator activity. Involved in several processes, including phosphatidylinositol 3-kinase signaling; positive regulation of peptidyl-serine phosphorylation; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within several processes, including energy homeostasis; negative regulation of apoptotic process; and protein kinase B signaling. Located in intercalated disc and lamellipodium. Part of phosphatidylinositol 3-kinase complex. Is expressed in several structures, including early embryo; eye; and nervous system. Used to study CLOVES syndrome and breast Cancer. Human ortholog(s) of this gene implicated in several diseases, including CLOVES syndrome; Cowden syndrome 5; breast Cancer (multiple); cutaneous Paget's disease; and gastrointestinal system Cancer (multiple). Orthologous to human PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Pik3ca Products(1)

mRNA Protein Name
NM_008839.3 NP_032865.2 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Pik3ca Protein Structure

PI3K_p85B

PI3K_p85B: pfam02192 (31 - 106)

PI3K_rbd

PI3K_rbd: smart00144 (172 - 291)

C2_PI3K_class_I_alpha

C2_PI3K_class_I_alpha: cd08398 (324 - 483)

PI3Ka_I

PI3Ka_I: cd00872 (524 - 695)

PI3Kc_IA_alpha

PI3Kc_IA_alpha: cd05175 (694 - 1063)

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  • 1068 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

PI3-kinase subunit alpha

PI3K-alpha

PI3Kalpha

phosphatidylinositol 3-kinase, catalytic, alpha polypeptide

phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha

phosphoinositide-3-kinase catalytic alpha polypeptide

ptdIns-3-kinase subunit alpha

ptdIns-3-kinase subunit p110-alpha

serine/threonine protein kinase PIK3CA

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15244 Alpelisib Inhibitor 99.95% Yes
Clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-13898 Taselisib Inhibitor 99.86% Phase 3
HY-10358 MK-2206 dihydrochloride 99.99% Phase 2
HY-108232 MK-2206 / Phase 2
HY-100886 BAY1082439 98.02% Phase 1
HY-137458 Vevorisertib Inhibitor / Phase 1
Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-137458A Vevorisertib trihydrochloride Inhibitor 99.13% Unkown
HY-126077 MTI-31 Inhibitor 99.94% Unkown
HY-10357 MK-2206 free base / Unkown
HY-N12726 Halociline Inhibitor / Unkown
HY-RS10523 PIK3CA Human Pre-designed siRNA Set A / Unkown
HY-RS10524 Pik3ca Mouse Pre-designed siRNA Set A / Unkown
HY-RS10525 Pik3ca Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pik3ca NCBI NCBI:5290