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Pik3ca - phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Gene

Also Known as p110; caPI3K; p110alpha; 6330412C24Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18706

About Pik3ca

Chromosome 3: 32,451,820-32,522,635 forward strand.GRCm39:CM000996.3

This gene has 4 transcripts (splice variants), 275 orthologues, 9 paralogues and is associated with 42 phenotypes. Ubiquitous expression in bladder adult (RPKM 6.2), cerebellum adult (RPKM 5.7) and 26 other tissues.

Summary

Enables 1-phosphatidylinositol-3-kinase activity; Insulin Receptor substrate binding activity; and protein kinase activator activity. Involved in several processes, including phosphatidylinositol 3-kinase signaling; positive regulation of peptidyl-serine phosphorylation; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within several processes, including energy homeostasis; negative regulation of apoptotic process; and protein kinase B signaling. Located in intercalated disc and lamellipodium. Part of phosphatidylinositol 3-kinase complex. Is expressed in several structures, including early embryo; eye; and nervous system. Used to study CLOVES syndrome and breast Cancer. Human ortholog(s) of this gene implicated in several diseases, including CLOVES syndrome; Cowden syndrome 5; breast Cancer (multiple); cutaneous Paget's disease; and gastrointestinal system Cancer (multiple). Orthologous to human PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Pik3ca Products (1)

mRNA	Protein	Name
NM_008839.3	NP_032865.2	phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 1-phosphatidylinositol-3-kinase activity	IDA IDA: Inferred from direct assay	11784871	MGI
enables 1-phosphatidylinositol-3-kinase activity	IMP IMP: Inferred from mutant phenotype	20197055	MGI
enables insulin receptor substrate binding	IPI IPI: Inferred from physical interaction	12486171	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7542745	MGI
enables protein kinase activator activity	IDA IDA: Inferred from direct assay	21047779	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	30568254	MGI
acts upstream of or within adipose tissue development	IMP IMP: Inferred from mutant phenotype	24691033	MGI
acts upstream of negative effect autosome genomic imprinting	IDA IDA: Inferred from direct assay	21047779	MGI
involved in cardiac muscle cell contraction	IMP IMP: Inferred from mutant phenotype	30568254	MGI
acts upstream of or within cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	24691033	MGI
involved in cellular response to hydrostatic pressure	IMP IMP: Inferred from mutant phenotype	30568254	MGI
acts upstream of or within energy homeostasis	IMP IMP: Inferred from mutant phenotype	24691033	MGI
acts upstream of or within glucose metabolic process	IMP IMP: Inferred from mutant phenotype	16625210	MGI
involved in insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	20197055	MGI
involved in insulin-like growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	11784871	MGI
involved in insulin-like growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	26872540	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	24691033	MGI
involved in negative regulation of actin filament depolymerization	IMP IMP: Inferred from mutant phenotype	30568254	MGI
acts upstream of or within negative regulation of fibroblast apoptotic process	IDA IDA: Inferred from direct assay	15192701	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	12904469	MGI
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	21047779	MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	16625210	MGI
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	30568254	MGI
involved in regulation of actin filament organization	IMP IMP: Inferred from mutant phenotype	30568254	MGI
acts upstream of or within regulation of cellular respiration	IMP IMP: Inferred from mutant phenotype	24691033	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	17475835	MGI
acts upstream of or within regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	16625210	MGI
acts upstream of or within regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	15192701	MGI
involved in relaxation of cardiac muscle	IMP IMP: Inferred from mutant phenotype	30568254	MGI
involved in response to muscle stretch	IMP IMP: Inferred from mutant phenotype	30568254	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in intercalated disc	IDA IDA: Inferred from direct assay	30568254	MGI
located in lamellipodium	IDA IDA: Inferred from direct assay	14657280	MGI
part of phosphatidylinositol 3-kinase complex	IPI IPI: Inferred from physical interaction	7542745	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pik3ca Protein Structure

PI3K_p85B

PI3K_rbd

C2_PI3K_class_I_alpha

PI3Ka_I

PI3Kc_IA_alpha

0
200
400
600
800
1000
1068 a.a.

Protein Preferred Names	Protein Names
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	PI3-kinase subunit alpha PI3K-alpha PI3Kalpha phosphatidylinositol 3-kinase, catalytic, alpha polypeptide phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha phosphoinositide-3-kinase catalytic alpha polypeptide ptdIns-3-kinase subunit alpha ptdIns-3-kinase subunit p110-alpha serine/threonine protein kinase PIK3CA

Pik3ca Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Pik3ca	P42337	Pik3r1	Mus musculus	P26450	Anti Bait CoIP	18449193
Intra	Pik3ca	P42337	Pik3r1	Mus musculus	P26450	Y2H	15102471

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-15244	Alpelisib	99.95%	Yes
HY-15244A	Alpelisib hydrochloride	99.55%	Yes
HY-15244R	Alpelisib (Standard)	99.86%	Unkown

Clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Phase
HY-153306	Zovegalisib	Inhibitor	98.80%	Phase 3
HY-13898	Taselisib	Inhibitor	99.75%	Phase 3
HY-108232	MK-2206		99.72%	Phase 2
HY-10358	MK-2206 dihydrochloride		99.99%	Phase 1
HY-100886	BAY1082439		99.35%	Phase 1
HY-137458A	Vevorisertib trihydrochloride	Inhibitor	98.05%	Phase 1
HY-126077	MTI-31	Inhibitor	99.98%	Phase 1
HY-10358R	MK-2206 dihydrochloride (Standard)		/	Phase 1

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-137458	Vevorisertib	Inhibitor	98.03%	Unkown
HY-137849	RK-582	Inhibitor	98.05%	Unkown
HY-RS10523	PIK3CA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-100424	PI3K-IN-63	Inhibitor	/	Unkown
HY-138302	PF-06862309		/	Unkown
HY-172964	KIM-161		/	Unkown
HY-183285	PI3Kα-IN-32	Inhibitor	/	Unkown
HY-183770	LCI40	Inhibitor	/	Unkown
HY-N12726	Halociline	Inhibitor	/	Unkown
HY-RS10524	Pik3ca Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10525	Pik3ca Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-116191	WJD008	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pik3ca	NCBI	NCBI:5290