2. Gene
  3. Rorc - RAR-related orphan receptor gamma Gene

Rorc - RAR-related orphan receptor gamma Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as TOR; Thor; Nr1f3; RORgamma

Gene ID: 19885 | Gene type: protein coding

About Rorc

Chromosome 3: 94,280,101-94,305,583 forward strand.GRCm39:CM000996.3

This gene has 4 transcripts (splice variants), 383 orthologues, 19 paralogues and is associated with 47 phenotypes. Biased expression in thymus adult (RPKM 78.6), colon adult (RPKM 8.4) and 9 other tissues.

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and transcription coactivator binding activity. Involved in several processes, including hematopoietic or lymphoid organ development; negative regulation of thymocyte apoptotic process; and regulation of gene expression. Acts upstream of or within hematopoietic or lymphoid organ development; protein phosphorylation; and regulation of gamma-delta T cell differentiation. Located in external side of plasma membrane and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; sensory organ; and thyroid gland. Used to study Sjogren's syndrome. Human ortholog(s) of this gene implicated in immunodeficiency 42. Orthologous to human RORC (RAR related orphan receptor C). [provided by Alliance of Genome Resources, Apr 2022]

Rorc Products(2)

mRNA Protein Name
NM_011281.3 NP_035411.2 nuclear receptor ROR-gamma isoform 1
NM_001293734.1 NP_001280663.1 nuclear receptor ROR-gamma isoform 2

Rorc Protein Structure

NR_DBD_ROR

NR_DBD_ROR: cd06968 (23 - 117)

NR_LBD_ROR_like

NR_LBD_ROR_like: cd06939 (265 - 503)

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  • 516 a.a.
Protein Preferred Names Protein Names

nuclear receptor ROR-gamma

RAR-related orphan receptor C

nuclear receptor RZR-gamma

nuclear receptor subfamily 1 group F member 3

retinoid-related orphan receptor-gamma

thymus orphan receptor

Related Agents

Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-112706 PF-06747711 Antagonist 99.86% Unkown
HY-19775 GNE-6468 98.04% Unkown
HY-19774 GNE-0946 98.09% Unkown
HY-128353 ROR agonist-1 Antagonist / Unkown
HY-148237 JNJ-54119936 / Unkown
HY-RS12132 RORC Human Pre-designed siRNA Set A / Unkown
HY-RS12133 Rorc Mouse Pre-designed siRNA Set A / Unkown
HY-RS12134 Rorc Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rorc NCBI NCBI:6097