Rorc - RAR-related orphan receptor gamma Gene

Also Known as TOR; Thor; Nr1f3; RORgamma

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19885

About Rorc

Chromosome 3: 94,280,101-94,305,583 forward strand.GRCm39:CM000996.3

This gene has 4 transcripts (splice variants), 383 orthologues, 19 paralogues and is associated with 47 phenotypes. Biased expression in thymus adult (RPKM 78.6), colon adult (RPKM 8.4) and 9 other tissues.

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and transcription coactivator binding activity. Involved in several processes, including hematopoietic or lymphoid organ development; negative regulation of thymocyte apoptotic process; and regulation of gene expression. Acts upstream of or within hematopoietic or lymphoid organ development; protein phosphorylation; and regulation of gamma-delta T cell differentiation. Located in external side of plasma membrane and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; sensory organ; and thyroid gland. Used to study Sjogren's syndrome. Human ortholog(s) of this gene implicated in immunodeficiency 42. Orthologous to human RORC (RAR related Orphan Receptor C). [provided by Alliance of Genome Resources, Apr 2022]

Rorc Products (2)

mRNA Protein Name
NM_011281.3 NP_035411.2 nuclear receptor ROR-gamma isoform 1
NM_001293734.1 NP_001280663.1 nuclear receptor ROR-gamma isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
21853531 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
18164222 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18368049 MGI
enables transcription coactivator binding IPI
IPI: Inferred from physical interaction
16148126 MGI
Biological Process GO Annotation Evidence References Source
involved in Peyer's patch development IMP
IMP: Inferred from mutant phenotype
14691482 MGI
acts upstream of or within T cell differentiation in thymus IMP
IMP: Inferred from mutant phenotype
15247480 MGI
acts upstream of or within T-helper 17 cell differentiation IDA
IDA: Inferred from direct assay
18792410 MGI
involved in T-helper 17 cell differentiation IMP
IMP: Inferred from mutant phenotype
16990136 MGI
involved in T-helper cell differentiation IMP
IMP: Inferred from mutant phenotype
14691482 MGI
involved in adipose tissue development IMP
IMP: Inferred from mutant phenotype
21853531 MGI
acts upstream of or within alpha-beta T cell differentiation IMP
IMP: Inferred from mutant phenotype
15247480 MGI
acts upstream of or within cell differentiation IMP
IMP: Inferred from mutant phenotype
14691482 MGI
involved in circadian regulation of gene expression IMP
IMP: Inferred from mutant phenotype
22753030 MGI
acts upstream of or within lymph node development IMP
IMP: Inferred from mutant phenotype
14691482 MGI
involved in lymph node development IMP
IMP: Inferred from mutant phenotype
14691482 MGI
acts upstream of or within mucosa-associated lymphoid tissue development IMP
IMP: Inferred from mutant phenotype
15247480 MGI
involved in negative regulation of thymocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
16148126 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
21628546 MGI
involved in positive regulation of circadian rhythm IDA
IDA: Inferred from direct assay
22753030 MGI
acts upstream of or within protein phosphorylation IMP
IMP: Inferred from mutant phenotype
15010863 MGI
involved in regulation of fat cell differentiation IMP
IMP: Inferred from mutant phenotype
21853531 MGI
acts upstream of or within regulation of gamma-delta T cell differentiation IDA
IDA: Inferred from direct assay
21737317 MGI
involved in regulation of glucose metabolic process IMP
IMP: Inferred from mutant phenotype
19965867 MGI
involved in regulation of steroid metabolic process IMP
IMP: Inferred from mutant phenotype
17666523 MGI
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18164222 MGI
involved in xenobiotic metabolic process IMP
IMP: Inferred from mutant phenotype
17666523 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
23034280 MGI
located in nucleus IDA
IDA: Inferred from direct assay
18368049 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Rorc Protein Structure

NR_DBD_ROR

NR_DBD_ROR: cd06968 (23 - 117)

NR_LBD_ROR_like

NR_LBD_ROR_like: cd06939 (265 - 503)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 516 a.a.
Protein Preferred Names Protein Names

nuclear receptor ROR-gamma

  • RAR-related orphan receptor C

  • nuclear receptor RZR-gamma

  • nuclear receptor subfamily 1 group F member 3

  • retinoid-related orphan receptor-gamma

  • thymus orphan receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19775 GNE-6468 Antagonist 98.02% Unkown
HY-112706 PF-06747711 Antagonist 99.83% Unkown
HY-19774 GNE-0946 Inhibitor 98.11% Unkown
HY-16983 GNE-3500 Antagonist 98.90% Unkown
HY-RS12132 RORC Human Pre-designed siRNA Set A / Unkown
HY-128353 ROR agonist-1 Antagonist / Unkown
HY-148237 JNJ-54119936 Antagonist / Unkown
HY-RS12133 Rorc Mouse Pre-designed siRNA Set A / Unkown
HY-RS12134 Rorc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180865 RORC modulator-1 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rorc NCBI NCBI:6097