Sstr5 - somatostatin receptor 5 Gene

Also Known as sst5; Smstr5

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20609

About Sstr5

Chromosome 17: 25,708,849-25,716,262 reverse strand.GRCm39:CM001010.3

This gene has 2 transcripts (splice variants), 257 orthologues, 15 paralogues and is associated with 12 phenotypes. Low expression observed in reference dataset.

Summary

Predicted to enable neuropeptide binding activity and Somatostatin Receptor activity. Acts upstream of or within glucose homeostasis and regulation of Insulin secretion. Located in plasma membrane. Human ortholog(s) of this gene implicated in bipolar disorder. Orthologous to human SSTR5 (Somatostatin Receptor 5). [provided by Alliance of Genome Resources, Apr 2022]

Sstr5 Products (2)

mRNA Protein Name
NM_001191008.1 NP_001177937.1 somatostatin receptor type 5
NM_011425.3 NP_035555.1 somatostatin receptor type 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21820437 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within glucose homeostasis IMP
IMP: Inferred from mutant phenotype
15919085 MGI
acts upstream of or within regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
15919085 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
21820437 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sstr5 Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (47 - 313)

7tm_GPCRs

7tm_GPCRs: cd14964 (72 - 93)

7tm_GPCRs

7tm_GPCRs: cd14964 (109 - 131)

7tm_GPCRs

7tm_GPCRs: cd14964 (154 - 170)

7tm_GPCRs

7tm_GPCRs: cd14964 (196 - 219)

7tm_GPCRs

7tm_GPCRs: cd14964 (245 - 267)

7tm_GPCRs

7tm_GPCRs: cd14964 (281 - 306)

  • 0
  • 100
  • 200
  • 300
  • 362 a.a.
Protein Preferred Names Protein Names

somatostatin receptor type 5

  • SS-5-R

  • SS5-R

  • SS5R

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P0036 Octreotide Agonist 99.96% Unkown
HY-P0036B Octreotide pamoate Agonist / Unkown

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1932 Cortistatin-14 99.98% Unkown
HY-P3954 Somatostatin-28 (sheep, human rat mouse) Inhibitor 99.67% Unkown
HY-P1203 BIM-23056 Antagonist 99.98% Unkown
HY-P3124A BIM-23190 hydrochloride Agonist 99.33% Unkown
HY-P4452 PRL 2915 Antagonist 99.92% Unkown
HY-P2090A Angiopeptin TFA Agonist 99.01% Unkown
HY-P3618 Cortistatin-29 (reduced) 98.12% Unkown
HY-P4469 PRL 3195 Antagonist / Unkown
HY-182905 SSTR5/TGR5-modulator-1 Modulator / Unkown
HY-P1203A BIM-23056 TFA Antagonist / Unkown
HY-160156 SSTR5 antagonist 4 Antagonist / Unkown
HY-P2434 AP102 / Unkown
HY-183205 SSTR5 antagonist 7 Antagonist / Unkown
HY-P3124 BIM-23190 Agonist / Unkown
HY-P2150 Cortistatin-29 (rat) / Unkown
HY-P2090 Angiopeptin Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sstr5 NCBI NCBI:6755