Sod2 - superoxide dismutase 2, mitochondrial Gene

Also Known as MnSOD; Sod-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20656

Summary

Enables superoxide dismutase activity. Acts upstream of or within several processes, including animal organ development; apoptotic signaling pathway; and regulation of cellular biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Used to study Canavan disease; Leigh disease; amyotrophic lateral sclerosis type 1; congestive heart failure; and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); lipid storage disease (multiple); liver disease (multiple); and optic nerve disease (multiple). Orthologous to human SOD2 (superoxide dismutase 2). [provided by Alliance of Genome Resources, Apr 2022]

Sod2 Products (1)

mRNA Protein Name
NM_013671.3 NP_038699.2 superoxide dismutase [Mn], mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables oxidoreductase activity IMP
IMP: Inferred from mutant phenotype
15205258 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21909133 MGI
enables superoxide dismutase activity IDA
IDA: Inferred from direct assay
7333654 MGI
enables superoxide dismutase activity IMP
IMP: Inferred from mutant phenotype
12176043 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure IMP
IMP: Inferred from mutant phenotype
16873728 MGI
acts upstream of or within apoptotic mitochondrial changes IMP
IMP: Inferred from mutant phenotype
11226230 MGI
acts upstream of or within detection of oxygen IMP
IMP: Inferred from mutant phenotype
11156968 MGI
acts upstream of or within erythrophore differentiation IMP
IMP: Inferred from mutant phenotype
15205258 MGI
acts upstream of or within glutathione metabolic process IMP
IMP: Inferred from mutant phenotype
10049502 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
7493016 MGI
acts upstream of or within hemopoiesis IMP
IMP: Inferred from mutant phenotype
8790408 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: Inferred from mutant phenotype
15642323 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to oxidative stress IMP
IMP: Inferred from mutant phenotype
15642323 MGI
acts upstream of or within liver development IMP
IMP: Inferred from mutant phenotype
17367743 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
8790408 MGI
acts upstream of or within mitochondrion organization IMP
IMP: Inferred from mutant phenotype
8790408 MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis IMP
IMP: Inferred from mutant phenotype
15205258 MGI
acts upstream of or within negative regulation of fat cell differentiation IMP
IMP: Inferred from mutant phenotype
16219542 MGI
acts upstream of or within negative regulation of fibroblast proliferation IDA
IDA: Inferred from direct assay
18218638 MGI
acts upstream of or within neuron development IMP
IMP: Inferred from mutant phenotype
8790408 MGI
acts upstream of or within positive regulation of nitric oxide biosynthetic process IMP
IMP: Inferred from mutant phenotype
15637112 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
7493016 MGI
acts upstream of or within regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
17023572 MGI
acts upstream of or within regulation of catalytic activity IMP
IMP: Inferred from mutant phenotype
9927656 MGI
acts upstream of or within regulation of mitochondrial membrane potential IMP
IMP: Inferred from mutant phenotype
17367743 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17670746 MGI
acts upstream of or within release of cytochrome c from mitochondria IMP
IMP: Inferred from mutant phenotype
10212301 MGI
acts upstream of or within removal of superoxide radicals IMP
IMP: Inferred from mutant phenotype
16873728 MGI
acts upstream of or within respiratory electron transport chain IMP
IMP: Inferred from mutant phenotype
11226230 MGI
acts upstream of or within response to activity IMP
IMP: Inferred from mutant phenotype
15781740 MGI
acts upstream of or within response to axon injury IMP
IMP: Inferred from mutant phenotype
16677818 MGI
acts upstream of or within response to gamma radiation IGI
IGI: Inferred from genetic interaction
15182862 MGI
acts upstream of or within response to hydrogen peroxide IMP
IMP: Inferred from mutant phenotype
15642323 MGI
acts upstream of or within response to hyperoxia IMP
IMP: Inferred from mutant phenotype
11796207 MGI
acts upstream of or within response to oxidative stress IGI
IGI: Inferred from genetic interaction
15182862 MGI
acts upstream of or within response to oxidative stress IMP
IMP: Inferred from mutant phenotype
15182862 MGI
acts upstream of or within response to reactive oxygen species IMP
IMP: Inferred from mutant phenotype
9462746 MGI
acts upstream of or within response to superoxide IMP
IMP: Inferred from mutant phenotype
11156968 MGI
NOT acts upstream of or within sensory perception of sound IMP
IMP: Inferred from mutant phenotype
16843623 MGI
acts upstream of or within superoxide anion generation IMP
IMP: Inferred from mutant phenotype
10212301 MGI
acts upstream of or within superoxide metabolic process IMP
IMP: Inferred from mutant phenotype
10049502 MGI
acts upstream of or within vasodilation IMP
IMP: Inferred from mutant phenotype
15637112 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
11583975 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

superoxide dismutase [Mn], mitochondrial

  • manganese SOD

  • manganese superoxide dismutase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-134476 NF-κΒ activator 1 Activator 99.59% Unkown
HY-134477 NF-κΒ activator 2 Activator 99.76% Unkown
HY-N7700A Guluronic acid sodium Inhibitor 98.0% Unkown
HY-W014940 Ethylene glycol dimethacrylate 99.52% Unkown
HY-158162 SIRT3 activator 1 Activator 98.14% Unkown
HY-175352 Nurr1 agonist 14 99.42% Unkown
HY-N7700 Guluronic acid Inhibitor 98.90% Unkown
HY-RS13560 SOD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W073128 Perfluorotetradecanoic acid 98.0% Unkown
HY-W248590 IR-775 chloride ≥98.0% Unkown
HY-179151 CDK4/6-IN-26 / Unkown
HY-182446 SRI-22818 Activator / Unkown
HY-181588 NR4A agonist-2 Agonist / Unkown
HY-RS16939 Sod2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23382 Sod2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sod2 NCBI NCBI:6648