Spn - sialophorin Gene

Also Known as Cd43; Ly48; Galgp; Ly-48; A630014B01Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20737

Summary

Enables heat shock protein binding activity. Involved in leukocyte tethering or rolling and positive regulation of T cell migration. Acts upstream of or within several processes, including positive regulation of macromolecule metabolic process; regulation of T cell activation; and regulation of defense response. Located in basement membrane; external side of plasma membrane; and uropod. Is integral component of plasma membrane. Orthologous to human SPN (sialophorin). [provided by Alliance of Genome Resources, Apr 2022]

Spn Products (2)

mRNA Protein Name
NM_001037810.2 NP_001032899.1 leukosialin precursor
NM_009259.5 NP_033285.1 leukosialin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables heat shock protein binding IPI
IPI: Inferred from physical interaction
20633027 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11238599 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within T cell costimulation IDA
IDA: Inferred from direct assay
7790813 MGI
acts upstream of T cell proliferation IDA
IDA: Inferred from direct assay
11380685 MGI
acts upstream of or within apoptotic signaling pathway IDA
IDA: Inferred from direct assay
10429671 MGI
acts upstream of or within cell surface receptor signaling pathway IDA
IDA: Inferred from direct assay
7790813 MGI
acts upstream of or within defense response to bacterium IMP
IMP: Inferred from mutant phenotype
10899905 MGI
involved in leukocyte tethering or rolling IMP
IMP: Inferred from mutant phenotype
26700769 MGI
acts upstream of or within negative regulation of T cell activation IMP
IMP: Inferred from mutant phenotype
9645617 MGI
acts upstream of or within negative regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
7566153 MGI
involved in negative regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
17638845 MGI
acts upstream of or within negative regulation of cell adhesion IDA
IDA: Inferred from direct assay
11937524 MGI
acts upstream of or within negative regulation of cell adhesion IMP
IMP: Inferred from mutant phenotype
7566153 MGI
acts upstream of or within negative regulation of type IV hypersensitivity IMP
IMP: Inferred from mutant phenotype
9645617 MGI
acts upstream of or within negative thymic T cell selection IMP
IMP: Inferred from mutant phenotype
10429671 MGI
involved in positive regulation of T cell migration IMP
IMP: Inferred from mutant phenotype
17638845 MGI
acts upstream of or within positive regulation of T cell proliferation IDA
IDA: Inferred from direct assay
7790813 MGI
acts upstream of or within positive regulation of protein phosphorylation IGI
IGI: Inferred from genetic interaction
20360400 MGI
acts upstream of or within positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
10899905 MGI
acts upstream of protein phosphorylation IGI
IGI: Inferred from genetic interaction
20360400 MGI
involved in regulation of T cell migration IMP
IMP: Inferred from mutant phenotype
21289089 MGI
acts upstream of or within regulation of defense response to virus IMP
IMP: Inferred from mutant phenotype
7566153 MGI
acts upstream of or within regulation of immune response IMP
IMP: Inferred from mutant phenotype
7566153 MGI
acts upstream of or within response to protozoan IDA
IDA: Inferred from direct assay
11994475 MGI
Cellular Component GO Annotation Evidence References Source
located in basement membrane IDA
IDA: Inferred from direct assay
7514104 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
7477353 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
11728336 MGI
located in uropod IDA
IDA: Inferred from direct assay
11728336 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leukosialin

  • 3E8 antigen

  • B-cell differentiation antigen LP-3

  • leukocyte sialoglycoprotein

  • lymphocyte antigen 48

Recombinant Spn Proteins

Cat. No. Product Name Accession Purity
HY-P75404 CD43 Protein, Mouse (HEK293, Fc) P15702 (D20-G248) ≥ 90%, as determined by Bis-Tris PAGE.
HY-P78258 CD43 Protein, Mouse (HEK293, His) P15702 (D20-G248) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-107434 Molindone Antagonist / Unkown

Pre-clinical Phase

Bioactive Molecules (25)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-149004 SLF1081851 Inhibitor 98.02% Unkown
HY-P0242A Neurokinin B TFA Agonist 99.36% Unkown
HY-162655 SLF80821178 Inhibitor 99.70% Unkown
HY-150254A SLB1122168 formic Inhibitor 99.91% Unkown
HY-150254 SLB1122168 Inhibitor / Unkown
HY-149004A SLF1081851 TFA Inhibitor / Unkown
HY-149004B SLF1081851 hydrochloride / Unkown
HY-156408 Spns2-IN-1 Inhibitor / Unkown
HY-162655A SLF80821178 hydrochloride Inhibitor / Unkown
HY-162996 Spns2-IN-2 Inhibitor / Unkown
HY-182375 (R)-SLB1122168 free base Inhibitor / Unkown
HY-182375A SLB1122168 free base Inhibitor / Unkown
HY-182456 CHDI-340246 Inhibitor / Unkown
HY-P10312 SPN009 Agonist / Unkown
HY-RS03666 DEAF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11006 PPP1R9B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13689 SPN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13690 SPNS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13691 SPNS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13692 SPNS3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-107434S Molindone-d8 Inhibitor 99.49% Unkown
HY-RS18595 Spn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19483 Spns2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25080 Spn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25976 Spns2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spn NCBI NCBI:6693