Aurkb - aurora kinase B Gene

Also Known as Aik2; Aim1; Ark2; AurB; IPL1; Stk5; AIM-1; AIRK2; STK-1; Stk12

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20877

About Aurkb

Chromosome 11: 68,936,473-68,942,490 forward strand.GRCm39:CM001004.3

This gene has 8 transcripts (splice variants), 217 orthologues, 2 paralogues and is associated with 23 phenotypes. Broad expression in thymus adult (RPKM 36.3), liver E14.5 (RPKM 33.6) and 19 other tissues.

Summary

This gene encodes a member of the Aurora Kinase subfamily of serine/threonine kinases. The genes encoding the Other two members of this subfamily are located on chromosomes 2 and 7. These kinases participate in the regulation of alignment and segregation of chromosomes during Mitosis and meiosis through association with microtubules. [provided by RefSeq, Sep 2015]

Aurkb Products (1)

mRNA Protein Name
NM_011496.2 NP_035626.1 aurora kinase B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables histone H3S28 kinase activity IDA
IDA: Inferred from direct assay
24034696 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
24034696 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
29518391 MGI
Biological Process GO Annotation Evidence References Source
involved in post-translational protein modification IDA
IDA: Inferred from direct assay
24034696 MGI
Cellular Component GO Annotation Evidence References Source
located in chromocenter IDA
IDA: Inferred from direct assay
19283064 MGI
located in chromosome IDA
IDA: Inferred from direct assay
26919979 MGI
part of chromosome passenger complex IDA
IDA: Inferred from direct assay
20562830 MGI
located in chromosome, centromeric region IDA
IDA: Inferred from direct assay
26919979 MGI
located in condensed chromosome, centromeric region IDA
IDA: Inferred from direct assay
14751927 MGI
located in midbody IDA
IDA: Inferred from direct assay
9514916 MGI
located in mitotic spindle midzone IDA
IDA: Inferred from direct assay
14751927 MGI
located in mitotic spindle pole IDA
IDA: Inferred from direct assay
26919979 MGI
located in nucleus IDA
IDA: Inferred from direct assay
14751927 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Aurkb Protein Structure

PKc_like

PKc_like: cl21453 (76 - 343)

  • 0
  • 100
  • 200
  • 300
  • 345 a.a.
Protein Preferred Names Protein Names

aurora kinase B

  • ARK-2

  • aurora 1

  • aurora B

  • aurora- and IPL1-like midbody-associated protein 1

  • aurora-related kinase 2

  • aurora/IPL1-related kinase 2

  • serine/threonine kinase 12

  • serine/threonine kinase 5

  • serine/threonine-protein kinase 12

  • serine/threonine-protein kinase 5

  • serine/threonine-protein kinase aurora-B

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (21)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-151971 Aurora kinase-IN-3 Inhibitor 99.02% Unkown
HY-168543 PROTAC AURKA degrader 3 Degrader 99.78% Unkown
HY-137344A dAURK-4 hydrochloride Degrader 98.14% Unkown
HY-175525 MS44 Degrader 99.89% Unkown
HY-157480 EGFR/AURKB-IN-1 Inhibitor 99.43% Unkown
HY-168540 PROTAC MPS1 degrader 1 99.90% Unkown
HY-180132 PROTAC AURKA degrader 2 Degrader 98.36% Unkown
HY-168545 SF-1 Ligand 99.50% Unkown
HY-RS01270 AURKB Human Pre-designed siRNA Set A / Unkown
HY-10338A Foretinib phosphate Inhibitor / Unkown
HY-116190 CFI-401870 Inhibitor / Unkown
HY-120279A CFI-400437 Inhibitor / Unkown
HY-123610 BRD-7880 Inhibitor / Unkown
HY-137344 dAURK-4 Degrader 99.93% Unkown
HY-175526 Aurora kinase ligand-1 / Unkown
HY-176191 Aurora kinase-IN-7 Inhibitor / Unkown
HY-184329 PROTAC AURKB Degrader-1 / Unkown
HY-N17821 Butrin / Unkown
HY-RS01271 Aurkb Mouse Pre-designed siRNA Set A / Unkown
HY-RS01272 Aurkb Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aurkb NCBI NCBI:9212