Kdm6b - KDM1 lysine (K)-specific demethylase 6B Gene

Also Known as Jmjd3; 1700064E03Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 216850

Summary

Enables beta-catenin binding activity; histone H3-tri/di-methyl-lysine-27 demethylase activity; and sequence-specific DNA binding activity. Involved in several processes, including histone H3-K27 demethylation; mesodermal cell differentiation; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including cellular response to hydrogen peroxide; histone demethylation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including brain; gut; liver; metanephros; and olfactory epithelium. Orthologous to human KDM6B (lysine demethylase 6B). [provided by Alliance of Genome Resources, Apr 2022]

Kdm6b Products (1)

mRNA	Protein	Name
NM_001017426.2	NP_001017426.1	lysine-specific demethylase 6B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	23856522	MGI
enables histone H3K27me2/H3K27me3 demethylase activity	IDA IDA: Inferred from direct assay	23856522	MGI
enables histone H3K27me2/H3K27me3 demethylase activity	IMP IMP: Inferred from mutant phenotype	17928865	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21095589	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17928865	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cardiac muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	23856522	MGI
acts upstream of or within cell fate commitment	IMP IMP: Inferred from mutant phenotype	18716661	MGI
acts upstream of or within cellular response to hydrogen peroxide	IDA IDA: Inferred from direct assay	20808772	MGI
involved in chromatin remodeling	IMP IMP: Inferred from mutant phenotype	21095589	MGI
involved in endothelial cell differentiation	IMP IMP: Inferred from mutant phenotype	23856522	MGI
involved in mesodermal cell differentiation	IMP IMP: Inferred from mutant phenotype	23856522	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	26625958	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17928865	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17928865	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23856522	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18716661	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	23856522	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
lysine-specific demethylase 6B	[histone H3]-trimethyl-L-lysine(27) demethylase 6B jmjC domain-containing protein 3 jumonji domain containing 3 jumonji domain-containing protein 3

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15648B	GSK-J4		99.45%	Unkown
HY-12304	IOX1	Inhibitor	99.89%	Unkown
HY-15648F	GSK-J4 hydrochloride	Inhibitor	99.01%	Unkown
HY-15648	GSK-J1	Inhibitor	99.94%	Unkown
HY-15648A	GSK-J2	Control	99.75%	Unkown
HY-100764	YUKA1	Inhibitor	99.15%	Unkown
HY-N6896	Isoviolanthin	Inhibitor	99.87%	Unkown
HY-15648D	GSK-J1 lithium salt	Inhibitor	98.33%	Unkown
HY-RS07223	KDM6B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-15648G	GSK-J1 sodium	Inhibitor	/	Unkown
HY-15648I	GSK-J2 sodium	Inhibitor	/	Unkown
HY-183618	DW-229	Degrader	/	Unkown
HY-RS17203	Kdm6b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23655	Kdm6b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kdm6b	NCBI	NCBI:23135