Wnt3a - wingless-type MMTV integration site family, member 3A Gene

Also Known as vt; Wnt-3a

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22416

Summary

Enables protein domain specific binding activity; signaling receptor binding activity; and transcription coactivator activity. Involved in several processes, including COP9 signalosome assembly; calcium ion transmembrane transport via low voltage-gated calcium channel; and nervous system development. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and positive regulation of macromolecule metabolic process. Located in cell surface and extracellular space. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; embryo ectoderm; genitourinary system; and sensory organ. Orthologous to human WNT3A (Wnt family member 3A). [provided by Alliance of Genome Resources, Apr 2022]

Wnt3a Products (1)

mRNA Protein Name
NM_009522.3 NP_033548.1 protein Wnt-3a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables frizzled binding IDA
IDA: Inferred from direct assay
19910923 MGI
enables frizzled binding IPI
IPI: Inferred from physical interaction
18606138 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
31036956 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10866835 MGI
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
15454084 MGI
enables receptor ligand activity IDA
IDA: Inferred from direct assay
10557084 MGI
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
17994217 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of B cell proliferation IDA
IDA: Inferred from direct assay
10933391 MGI
involved in COP9 signalosome assembly IDA
IDA: Inferred from direct assay
17569865 MGI
involved in Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
16115200 MGI
acts upstream of or within Wnt signaling pathway involved in forebrain neuroblast division IMP
IMP: Inferred from mutant phenotype
10631167 MGI
acts upstream of or within anterior/posterior pattern specification IDA
IDA: Inferred from direct assay
15148409 MGI
acts upstream of or within axis elongation involved in somitogenesis IGI
IGI: Inferred from genetic interaction
11029008 MGI
acts upstream of or within axon guidance IDA
IDA: Inferred from direct assay
18716223 MGI
acts upstream of or within axonogenesis IDA
IDA: Inferred from direct assay
15454084 MGI
acts upstream of or within axonogenesis IGI
IGI: Inferred from genetic interaction
15454084 MGI
involved in calcium ion transmembrane transport via low voltage-gated calcium channel IDA
IDA: Inferred from direct assay
20371816 MGI
acts upstream of or within canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
31222549 MGI
involved in canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
10557084 MGI
involved in canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
10409711 MGI
involved in canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
19701191 MGI
acts upstream of or within cardiac muscle cell fate commitment IGI
IGI: Inferred from genetic interaction
21554246 MGI
involved in cell proliferation in forebrain IDA
IDA: Inferred from direct assay
12843296 MGI
involved in cell proliferation in midbrain IDA
IDA: Inferred from direct assay
14557550 MGI
acts upstream of cytokine production IDA
IDA: Inferred from direct assay
23677472 MGI
acts upstream of or within determination of left/right symmetry IMP
IMP: Inferred from mutant phenotype
16291790 MGI
acts upstream of or within dorsal/ventral neural tube patterning IMP
IMP: Inferred from mutant phenotype
8299937 MGI
acts upstream of or within extracellular matrix organization IDA
IDA: Inferred from direct assay
17943183 MGI
acts upstream of fat cell differentiation IDA
IDA: Inferred from direct assay
17888405 MGI
acts upstream of fat cell differentiation IGI
IGI: Inferred from genetic interaction
17888405 MGI
acts upstream of or within heart looping IMP
IMP: Inferred from mutant phenotype
16291790 MGI
acts upstream of or within hemopoiesis IDA
IDA: Inferred from direct assay
12717450 MGI
acts upstream of or within hippocampus development IMP
IMP: Inferred from mutant phenotype
10631167 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
4819561 MGI
acts upstream of or within inner ear morphogenesis IGI
IGI: Inferred from genetic interaction
15961523 MGI
acts upstream of or within mammary gland development IDA
IDA: Inferred from direct assay
15342465 MGI
acts upstream of or within mesoderm development IMP
IMP: Inferred from mutant phenotype
8299937 MGI
involved in midbrain development IDA
IDA: Inferred from direct assay
14557550 MGI
involved in modulation of chemical synaptic transmission EXP
EXP: Inferred from Experiment
16501258 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
16501258 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
16501258 MGI
acts upstream of or within myoblast differentiation IGI
IGI: Inferred from genetic interaction
19699733 MGI
acts upstream of or within negative regulation of axon extension involved in axon guidance IDA
IDA: Inferred from direct assay
18716223 MGI
involved in negative regulation of dopaminergic neuron differentiation IDA
IDA: Inferred from direct assay
14557550 MGI
acts upstream of or within negative regulation of fat cell differentiation IDA
IDA: Inferred from direct assay
15796911 MGI
acts upstream of or within negative regulation of fat cell differentiation IGI
IGI: Inferred from genetic interaction
17888405 MGI
involved in negative regulation of neurogenesis IDA
IDA: Inferred from direct assay
12843296 MGI
involved in negative regulation of neuron projection development IDA
IDA: Inferred from direct assay
21539518 MGI
involved in neurogenesis IDA
IDA: Inferred from direct assay
14557550 MGI
involved in non-canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
17244647 MGI
acts upstream of or within osteoblast differentiation IGI
IGI: Inferred from genetic interaction
16581771 MGI
acts upstream of or within paraxial mesodermal cell fate commitment IMP
IMP: Inferred from mutant phenotype
9126297 MGI
acts upstream of or within platelet activation IDA
IDA: Inferred from direct assay
19901330 MGI
acts upstream of or within platelet aggregation IDA
IDA: Inferred from direct assay
19901330 MGI
acts upstream of or within positive regulation of B cell proliferation IDA
IDA: Inferred from direct assay
10933391 MGI
involved in positive regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
18929644 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
9356179 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
17994217 MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
18155657 MGI
acts upstream of or within positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
19690384 MGI
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
17994217 MGI
acts upstream of or within positive regulation of cell-cell adhesion mediated by cadherin IDA
IDA: Inferred from direct assay
10893270 MGI
acts upstream of or within positive regulation of collateral sprouting in absence of injury IDA
IDA: Inferred from direct assay
18716223 MGI
acts upstream of or within positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
17251350 MGI
acts upstream of or within positive regulation of cytokine production IDA
IDA: Inferred from direct assay
23677472 MGI
acts upstream of or within positive regulation of hepatocyte proliferation IDA
IDA: Inferred from direct assay
23740243 MGI
acts upstream of or within positive regulation of neural precursor cell proliferation IDA
IDA: Inferred from direct assay
19896444 MGI
involved in positive regulation of protein localization to plasma membrane IDA
IDA: Inferred from direct assay
22899650 MGI
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
17027228 MGI
acts upstream of or within positive regulation of protein tyrosine kinase activity IGI
IGI: Inferred from genetic interaction
19920076 MGI
involved in positive regulation of skeletal muscle tissue development IMP
IMP: Inferred from mutant phenotype
11856745 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
23740243 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
20371816 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
19699733 MGI
acts upstream of or within positive effect positive regulation of type B pancreatic cell proliferation IDA
IDA: Inferred from direct assay
17994217 MGI
acts upstream of or within post-anal tail morphogenesis IMP
IMP: Inferred from mutant phenotype
8299937 MGI
acts upstream of or within protein localization IDA
IDA: Inferred from direct assay
17606995 MGI
acts upstream of or within regulation of RNA biosynthetic process IDA
IDA: Inferred from direct assay
22665494 MGI
acts upstream of or within regulation of axonogenesis IGI
IGI: Inferred from genetic interaction
18716223 MGI
acts upstream of or within regulation of cell differentiation IDA
IDA: Inferred from direct assay
12717450 MGI
acts upstream of or within regulation of microtubule cytoskeleton organization IGI
IGI: Inferred from genetic interaction
18716223 MGI
involved in regulation of postsynapse to nucleus signaling pathway EXP
EXP: Inferred from Experiment
16501258 MGI
involved in regulation of postsynapse to nucleus signaling pathway IDA
IDA: Inferred from direct assay
16501258 MGI
acts upstream of or within skeletal muscle cell differentiation IGI
IGI: Inferred from genetic interaction
19699733 MGI
acts upstream of or within somatic stem cell division IDA
IDA: Inferred from direct assay
12717450 MGI
acts upstream of or within somitogenesis IMP
IMP: Inferred from mutant phenotype
8299937 MGI
acts upstream of or within spinal cord association neuron differentiation IDA
IDA: Inferred from direct assay
11877374 MGI
acts upstream of or within spinal cord association neuron differentiation IGI
IGI: Inferred from genetic interaction
11877374 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
19699733 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
8167409 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
12897152 MGI
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
16501258 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
16501258 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
16501258 MGI
is active in synapse IDA
IDA: Inferred from direct assay
16501258 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein Wnt-3a

  • vestigial tail

  • wingless-related MMTV integration site 3A

Wnt3a Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Wnt3a P27467 AFM Homo sapiens P43652
GMS
26902720
Intra
Wnt3a P27467 AFM Homo sapiens P43652
Anti Tag CoIP
26902720
Cross
Wnt3a P27467 LRP6 Homo sapiens O75581
Comig Non-Denat Gel
23791946
Intra
Wnt3a P27467 Fzd8 Mus musculus Q61091
Pull Down
31036956
Intra
Wnt3a P27467 Fzd8 Mus musculus Q61091
Anti Tag CoIP
31036956
Cross
Wnt3a P27467 WIF1 Homo sapiens Q9Y5W5
Competition Binding
22986341
Cross
Wnt3a P27467 TRABD2B Homo sapiens A6NFA1
Protease Assay
22726442
Intra
Wnt3a P27467 Ptpro Mus musculus E9Q612
Anti Tag CoIP
20804755
Intra
Wnt3a P27467 Ptpro Mus musculus E9Q612
Crosslink
20804755
Cross
Wnt3a P27467 AFM Bos taurus G3MYZ3
Anti Tag CoIP
26902720
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. 상품명 효과
Purity Rare Diseases
HY-B0194 Tizanidine 99.58% Unkown
HY-B0194A Tizanidine hydrochloride 99.93% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. 상품명 효과
Purity Phase
HY-153855 Zamaporvint Inhibitor 99.76% Phase 2

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-129079A TFMB-(S)-2-HG Inhibitor 99.79% Unkown
HY-122832 ABC99 Inhibitor 98.48% Unkown
HY-B0194S Tizanidine-d4 99.93% Unkown
HY-N2896 Arjunolic acid 98.83% Unkown
HY-160709 Wnt/β-catenin-IN-2 Inhibitor 99.46% Unkown
HY-181248 BChE-IN-49 / Unkown
HY-B0194AS Tizanidine-d4 hydrochloride / Unkown
HY-P10204 FZD7 antagonist 1 / Unkown
HY-P11606 WNT3Ap Substrate / Unkown
HY-P11867 UM206_L Activator / Unkown
HY-P11867A UM206_C Activator / Unkown
HY-RS15835 WNT3A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-124841 Gallocyanine / Unkown
HY-148637 Picoberin Agonist / Unkown
HY-RS16706 Wnt3a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23141 Wnt3a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-P990841 Anti-pan-Glypican Antibody (HS20) Inhibitor 99.44% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wnt3a NCBI NCBI:89780