WNT3A - Wnt family member 3A Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 89780

About WNT3A

Cytogenetic location: 1q42.13 Genomic coordinates (GRCh38): 1:228,006,998-228,061,271 (from NCBI)

This gene has 1 transcript (splice variant), 206 orthologues, 18 paralogues and is associated with 1 phenotype. Biased expression in placenta (RPKM 9.0), lung (RPKM 1.6) and 1 other tissue.

Summary

The Wnt gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the Wnt gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human Wnt3 protein, another Wnt gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region. [provided by RefSeq, Jul 2008]

WNT3A Products (1)

mRNA	Protein	Name
NM_033131.4	NP_149122.1	protein Wnt-3a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables co-receptor binding	IPI IPI: Inferred from physical interaction	20093360	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19072540	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	19736317	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	20093360	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	16890161	GOA
involved in canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	26902720	GOA
involved in cardiac muscle cell fate commitment	IDA IDA: Inferred from direct assay	20559569	GOA
involved in cell population proliferation	IMP IMP: Inferred from mutant phenotype	26902720	GOA
involved in heart development	IDA IDA: Inferred from direct assay	19736317	GOA
involved in positive regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	20137080	GOA
acts upstream of positive regulation of cardiac muscle cell differentiation	IDA IDA: Inferred from direct assay	20559569	GOA
involved in positive regulation of dermatome development	IDA IDA: Inferred from direct assay	10654605	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	26687115	GOA
involved in positive regulation of mesodermal cell fate specification	IDA IDA: Inferred from direct assay	20559569	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	20723538	GOA
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	20137080	GOA
involved in positive regulation of receptor internalization	IDA IDA: Inferred from direct assay	16890161	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20723538	GOA
involved in regulation of presynapse assembly	IDA IDA: Inferred from direct assay	19883499	GOA
involved in regulation of presynapse assembly	IMP IMP: Inferred from mutant phenotype	19883499	GOA
involved in regulation of synapse organization	IDA IDA: Inferred from direct assay	18986540	GOA
involved in regulation of synapse organization	IMP IMP: Inferred from mutant phenotype	18986540	GOA
involved in secondary palate development	IMP IMP: Inferred from mutant phenotype	18413325	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Wnt-Frizzled-LRP5/6 complex	IDA IDA: Inferred from direct assay	20093360	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	26902720	GOA
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	18986540	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	18986540	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WNT3A Protein Structure

wnt

0
100
200
300
352 a.a.

Protein Preferred Names	Protein Names
protein Wnt-3a	wingless-type MMTV integration site family, member 3A

WNT3A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	WNT3A	P56704	WLS	Homo sapiens	Q5T9L3	Anti Tag CoIP	22784633
Intra	WNT3A	P56704	WLS	Homo sapiens	Q5T9L3	Anti Tag CoIP	33961781
Intra	WNT3A	P56704	WLS	Homo sapiens	Q5T9L3	IF	24768165
Intra	WNT3A	P56704	WLS	Homo sapiens	Q5T9L3	Anti Tag CoIP	24768165
Intra	WNT3A	P56704	FZD8	Homo sapiens	Q9H461	Pull Down	22682250
Intra	WNT3A	P56704	LRP6	Homo sapiens	O75581	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

WNT3A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83724	Wnt3a Antibody	WB, IHC-P, ICC/IF	Human
HY-P85627	Wnt3a Antibody (YA5319)	WB	Human

Related Diseases

Diseases	Alias
Osteoporosis, Juvenile	Idiopathic Juvenile Osteoporosis Idiopathic Osteoporosis Juvenile Osteoporosis Ijo
Hypotrichosis Simplex	Hereditary Hypotrichosis Simplex Hhs
Hypotrichosis
Craniodiaphyseal Dysplasia, Autosomal Dominant	CDD Autosomal Dominant Craniodiaphyseal Dysplasia Schaefer Stein Oshman Syndrome Craniodiaphyseal Dysplasia Autosomal Dominant
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Severe Congenital Neutropenia	Congenital Neutropenia Neutropenia, Severe Congenital Congenital Agranulocytosis Infantile Genetic Agranulocytosis Kostmann Disease Kostmann'S Agranulocytosis Kostmann'S Syndrome Severe Infantile Genetic Neutropenia
Osteoporosis-Pseudoglioma Syndrome	OPPG Ops Osteoporosis With Pseudoglioma Osteogenesis Imperfecta, Ocular Form Ocular Form Of Osteogenesis Imperfecta Osteogenesis Imperfecta Ocular Form Osteoporosis Pseudoglioma Syndrome Pseudoglioma With Bone Fragility
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Focal Dermal Hypoplasia	Goltz Syndrome Goltz-Gorlin Syndrome FDH FODH Dhof Goltz Gorlin Syndrome Hypoplasia, Dermal, Focal
Exudative Vitreoretinopathy	Familial Exudative Vitreoretinopathy Fevr Criswick-Schepens Syndrome Exudative Vitreoretinopathy, Familial Vitreoretinopathy, Exudative ) Exudative Vitreoretinopathy 1
Sclerosteosis	Cortical Hyperostosis With Syndactyly Sost Cortical Hyperostosis-Syndactyly Syndrome
Van Buchem Disease	Hyperostosis Corticalis Generalisata Hyperphosphatasemia Tarda VBCH Sost-Related Sclerosing Bone Dysplasia Endosteal Hyperostosis Autosomal Recessive Sclerosteosis Endosteal Hyperostosis, Autosomal Recessive Hyperotosis Corticalis Generalisata Familiaris Sost Sclerosing Bone Dysplasia Smith-Lemli-Opitz Syndrome
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Robinow Syndrome	Acral Dysostosis With Facial And Genital Abnormalities Fetal Face Syndrome Robinow Dwarfism Mesomelic Dwarfism-Small Genitalia Syndrome Robinow-Silverman-Smith Syndrome Costovertebral Segmentation Defect With Mesomelia Covesdem Syndrome Robinow'S Syndrome Robinow-Silverman Syndrome
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Tetraamelia Syndrome	Tetra-Amelia Syndrome Tetraamelia-Multiple Malformations Syndrome Tetra-Amelia Tetra-Amelia, Autosomal Recessive Tetraamelia, Autosomal Recessive Total Amelia Zimmer Phocomelia Tetams Zimmer Taub Sova Syndrome
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Microphthalmia	Microphthalmos Isolated Anophthalmia-Microphthalmia Syndrome Isolated Microphthalmia-Anophthalmia-Coloboma Simple Microphthalmos Clinical Anophthalmia Isolated Anophthalmia - Microphthalmia Isolated Pure Microphthalmia Mac Spectrum Microphthalmia-Anophthalmia-Coloboma Spectrum Primitive Anophthalmia Globe Of Eye Small Small Eyeball Hypoplasia Of Eye Isolated Nanophthalmos Rudimentary Eye Dysplasia Of Eye
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Norrie Disease	Atrophia Bulborum Hereditaria Episkopi Blindness Pseudoglioma ND Norrie-Warburg Disease Anderson-Warburg Syndrome Fetal Iritis Syndrome Norrie Syndrome Norrie-Warburg Syndrome Ndp Congenital Progressive Oculo-Acoustico-Cerebral Degeneration Norrie'S Disease Oligophrenia Microphthalmus Pseudoglioma Congenita Whitnall-Norman Syndrome
Scoliosis
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Cleft Palate, Isolated	Cleft Palate Isolated Cleft Palate CPI Cp Palatoschisis Cleft Palate Isolated Uranostaphyloschisis Congenital Fissure Of Palate Cleft Of Secondary Palate
Colonic Benign Neoplasm	Colon Neoplasm Colonic Mass Colonic Tumor Neoplasm Of Colon Neoplasm Of The Colon Colonic Neoplasms Colon Cancer Colon Carcinoma Nos Colonic Cancer Metastatic Colon Cancer Nos
Brittle Bone Disorder	Osteogenesis Imperfecta Brittle Bone Disease Fragilitas Ossium Osteopsathyrosis Lobstein Disease Oi Vrolik Disease Lobstein'S Disease Lobstein'S Syndrome Vrolik'S Disease Porak And Durante Disease Glass Bone Disease Osteogenesis Imperfecta, Dominant Perinatal Lethal Osteogenesis Imperfecta, Recessive Perinatal Lethal Brittle Bone Syndrome Oi - [Osteogenesis Imperfecta] Ossium Fragility Osteitis Fragilitans Bony Fragility Blue Sclera With Fragility Of Bone And Deafness White Blue Sclera - Fragility Of Bone - Deafness
Orofacial Cleft	Cleft, Orofacial
Osteochondrodysplasia	Skeletal Dysplasia Chondrodystrophy Congenital Anomaly Of Cartilage Osteochondrodysplasias Cartilage Development Disorder Osteochondrodysplasia Syndrome Dysplasia, Skeletal Mucopolysaccharidosis Iv
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0194	Tizanidine		99.58%	Unkown
HY-B0194A	Tizanidine hydrochloride		99.93%	Yes

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-153855	Zamaporvint	Inhibitor	99.76%	Phase 2

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-129079A	TFMB-(S)-2-HG	Inhibitor	99.79%	Unkown
HY-122832	ABC99	Inhibitor	98.48%	Unkown
HY-B0194S	Tizanidine-d4		99.93%	Unkown
HY-N2896	Arjunolic acid		98.83%	Unkown
HY-160709	Wnt/β-catenin-IN-2	Inhibitor	99.46%	Unkown
HY-181248	BChE-IN-49		/	Unkown
HY-B0194AS	Tizanidine-d4 hydrochloride		/	Unkown
HY-P10204	FZD7 antagonist 1		/	Unkown
HY-P11606	WNT3Ap	Substrate	/	Unkown
HY-P11867	UM206_L	Activator	/	Unkown
HY-P11867A	UM206_C	Activator	/	Unkown
HY-RS15835	WNT3A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-124841	Gallocyanine		/	Unkown
HY-148637	Picoberin	Agonist	/	Unkown
HY-RS16706	Wnt3a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23141	Wnt3a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990841	Anti-pan-Glypican Antibody (HS20)	Inhibitor	99.44%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	WNT3A	MGD	MGI:98956
Macaca mulatta	WNT3A	VGNC	VGNC:106529
Canis familiaris	WNT3A	VGNC	VGNC:54800
Bos taurus	WNT3A	VGNC	VGNC:52903
Rattus norvegicus	WNT3A	RGD	RGD:1308057
Felis catus	WNT3A	VGNC	VGNC:102362
Others	WNT3A	NCBI