METAP1 - methionyl aminopeptidase 1 Gene

Also Known as MAP1A; MetAP1A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23173

About METAP1

Cytogenetic location: 4q23 Genomic coordinates (GRCh38): 4:98,995,721-99,062,809 (from NCBI)

This gene has 12 transcripts (splice variants), 211 orthologues and 7 paralogues. Ubiquitous expression in esophagus (RPKM 20.9), testis (RPKM 19.8) and 25 other tissues.

Summary

Predicted to enable Aminopeptidase activity and metalloexopeptidase activity. Involved in platelet aggregation. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

METAP1 Products (1)

mRNA Protein Name
NM_015143.3 NP_055958.2 methionine aminopeptidase 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables aminopeptidase activity IDA
IDA: Inferred from direct assay
17114291 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in protein maturation IDA
IDA: Inferred from direct assay
17114291 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

METAP1 Protein Structure

Peptidase_M24

Peptidase_M24: Metallopeptidase family M24 (137 - 365)

  • 0
  • 100
  • 200
  • 300
  • 386 a.a.
Protein Preferred Names Protein Names

methionine aminopeptidase 1

  • MAP 1

METAP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
METAP1 P53582 NBR1 Homo sapiens Q14596-2
Validated Y2H
32296183
Intra
METAP1 P53582 NBR1 Homo sapiens Q14596-2
Y2H Array
32296183
Intra
METAP1 P53582 NBR1 Homo sapiens Q14596-2
Y2H Prey Pooling
32296183
Intra
METAP1 P53582 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
METAP1 P53582 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
METAP1 P53582 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
METAP1 P53582 GLRX3 Homo sapiens O76003
Y2H Prey Pooling
32296183
Intra
METAP1 P53582 GLRX3 Homo sapiens O76003
Y2H Array
32296183
Intra
METAP1 P53582 ZRANB1 Homo sapiens Q9UGI0
Validated Y2H
32296183
Intra
METAP1 P53582 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
Intra
METAP1 P53582 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
Intra
METAP1 P53582 INCA1 Homo sapiens Q0VD86
Validated Y2H
32296183
Intra
METAP1 P53582 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
METAP1 P53582 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
METAP1 P53582 PLEKHG4 Homo sapiens Q58EX7
Validated Y2H
32296183
Intra
METAP1 P53582 PLEKHG4 Homo sapiens Q58EX7
Y2H Array
32296183
Intra
METAP1 P53582 PLEKHG4 Homo sapiens Q58EX7
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant METAP1 Proteins

Cat. No. Product Name Accession Purity
HY-P70380 METAP1/Methionine aminopeptidase 1 Protein, Human P53582 (M1-F386) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Microsporidiosis

  • Infection By Microspora

  • Microsporidiasis

  • Infection By Microsporea

  • Infection By Microsporida

  • Intestinal Microsporidiosis

  • Microsporidia Infection

  • Infection By Microsporidia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-119062 A-800141 Inhibitor / Unkown
HY-118953 LAF389 Inhibitor / Unkown
HY-116861 A-357300 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus METAP1 MGD MGI:1922874
Felis catus METAP1 VGNC VGNC:63454
Macaca mulatta METAP1 VGNC VGNC:74514
Rattus norvegicus METAP1 RGD RGD:1305545
Canis familiaris METAP1 VGNC VGNC:43167
Bos taurus METAP1 VGNC VGNC:31395
Others METAP1 NCBI