Gipr - gastric inhibitory polypeptide receptor Gene

Also Known as Gippr; RATGIPPR

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25024

Summary

Enables gastric inhibitory peptide receptor activity and peptide hormone binding activity. Involved in several processes, including desensitization of G protein-coupled receptor signaling pathway; positive regulation of cell communication; and response to glucose. Located in plasma membrane. Used to study type 2 diabetes mellitus. Biomarker of hyperglycemia. Human ortholog(s) of this gene implicated in cardiovascular system disease; diabetes mellitus; and obesity. Orthologous to human GIPR (gastric inhibitory polypeptide receptor). [provided by Alliance of Genome Resources, Apr 2022]

Gipr Products (2)

mRNA Protein Name
NM_012714.2 NP_036846.1 gastric inhibitory polypeptide receptor precursor
NM_012714.2 NP_036846.1 gastric inhibitory polypeptide receptor precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables gastric inhibitory peptide receptor activity IDA
IDA: Inferred from direct assay
8958204 RGD
enables peptide hormone binding IPI
IPI: Inferred from physical interaction
8958204 RGD
Biological Process GO Annotation Evidence References Source
involved in desensitization of G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
8928774 RGD
involved in gastric inhibitory peptide signaling pathway IMP
IMP: Inferred from mutant phenotype
11014226 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
8243312 RGD
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
11014226 RGD
involved in response to axon injury IEP
IEP: Inferred from expression pattern
19170165 RGD
involved in response to calcium ion IMP
IMP: Inferred from mutant phenotype
9705086 RGD
involved in response to fatty acid IEP
IEP: Inferred from expression pattern
12475913 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
12475913 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gastric inhibitory polypeptide receptor

  • GIP-R

  • gastric inhibitory peptide receptor

  • glucose-dependent insulinotropic polypeptide receptor

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-P11672 Poterepatide Agonist 99.78% Phase 3
HY-P3506B Retatrutide acetate Agonist 99.69% Phase 3
HY-164535 Maridebart cafraglutide 99.24% Phase 1
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990047 Maridebart Inhibitor 99.90% Phase 3

Pre-clinical Phase

Bioactive Molecules (28)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P3506 Retatrutide Agonist 99.96% Unkown
HY-P10735 GIP (mouse) 98.79% Unkown
HY-P3506A Retatrutide TFA Agonist 99.47% Unkown
HY-P10736A AMG133 peptide payload TFA Agonist 99.70% Unkown
HY-P10736 AMG133 peptide payload 99.94% Unkown
HY-P10302A GLP-1R/GIPR agonist-1 (soduim) Agonist 98.24% Unkown
HY-P10271 RG7697 Agonist 99.90% Unkown
HY-P11321A IUB0271 hydrochloride 98.67% Unkown
HY-P3584A (Pro3) GIP, human TFA 99.89% Unkown
HY-P10031 SAR441255 Agonist 99.84% Unkown
HY-P10031A SAR441255 TFA Agonist 99.93% Unkown
HY-186050 GIPR antagonist 2 Agonist 99.48% Unkown
HY-P10302 GLP-1R/GIPR agonist-1 Agonist / Unkown
HY-P3584 (Pro3) GIP, human Agonist 99.79% Unkown
HY-171302 GLP-1R/GIPR agonist-2 Agonist / Unkown
HY-173479 GLP-1R agonist 30 Agonist / Unkown
HY-179332 GIPR antagonist 1 / Unkown
HY-181709 TPM003 Agonist / Unkown
HY-182580 HBK001 / Unkown
HY-P11275 TC4 Agonist / Unkown
HY-P11279 TC2 Agonist / Unkown
HY-P11321 IUB0271 / Unkown
HY-P11487 UTG-4 Agonist / Unkown
HY-P11818 GIPR/GLP-1R/GCGR agonist-1 / Unkown
HY-P11880 LY3324954 Agonist / Unkown
HY-RS05437 GIPR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17884 Gipr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24353 Gipr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gipr NCBI NCBI:2696
Macaca fascicularis Gipr NCBI NCBI:102123760
Mus musculus Gipr NCBI NCBI:381853