Mmp7 - matrix metallopeptidase 7 Gene

Also Known as MPMM

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25335

About Mmp7

Primary_assembly 8: 4,848,186-4,855,902 forward strand.mRatBN7.2:CM026981.1

This gene has 3 transcripts (splice variants), 163 orthologues, 23 paralogues and is associated with 35 phenotypes. Restricted expression toward (RPKM 175.4).

Summary

Enables heparin binding activity. Involved in several processes, including cellular response to mechanical stimulus; estrous cycle; and maternal process involved in female pregnancy. Located in cell surface and extracellular space. Used to study hypertension and prostate carcinoma. Biomarker of bladder neck obstruction; coronary restenosis; hypertension; prostate cancer; and renal hypertension. Orthologous to human MMP7 (matrix metallopeptidase 7). [provided by Alliance of Genome Resources, Apr 2022]

Mmp7 Products (1)

mRNA Protein Name
NM_012864.2 NP_036996.1 matrilysin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables heparin binding IDA
IDA: Inferred from direct assay
10660581 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
20054150 RGD
involved in estrous cycle IEP
IEP: Inferred from expression pattern
10070364 RGD
involved in maternal process involved in female pregnancy IEP
IEP: Inferred from expression pattern
10645258 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
17670906 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in cell surface IDA
IDA: Inferred from direct assay
10660581 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
23256367 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mmp7 Protein Structure

PG_binding_1

PG_binding_1: pfam01471 (33 - 84)

Peptidase_M10

Peptidase_M10: pfam00413 (105 - 261)

  • 0
  • 100
  • 200
  • 267 a.a.
Protein Preferred Names Protein Names

matrilysin

  • MMP-7

  • Matrix metalloproteinase 7 (matrilysin)

  • matrin

  • matrix metalloproteinase-7

  • pump-1 protease

  • uterine metalloproteinase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-12169 Marimastat Inhibitor 99.90% Phase 3

Pre-clinical Phase

Bioactive Molecules (23)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-13564 Batimastat Inhibitor 98.92% Unkown
HY-131498 Mca-PLGL-Dpa-AR-NH2 Substrate 99.86% Unkown
HY-103444 ARP-100 Inhibitor ≥99.0% Unkown
HY-N0774 Isofraxidin Inhibitor 99.94% Unkown
HY-151540 MMP-7-IN-1 Inhibitor 99.37% Unkown
HY-119423 MMP Inhibitor II Inhibitor 99.7% Unkown
HY-156430 MMP-7-IN-3 Inhibitor 99.74% Unkown
HY-153563 MMP-7-IN-2 Inhibitor 99.08% Unkown
HY-161169A TP0628103 TFA Inhibitor 99.90% Unkown
HY-15606 Tanaproget Agonist 99.73% Unkown
HY-RS08552 Mmp7 Mouse Pre-designed siRNA Set A / Unkown
HY-13564A Batimastat sodium salt Inhibitor 99.04% Unkown
HY-130076 MMP-2 Inhibitor II Inhibitor 98.0% Unkown
HY-P3123A Dnp-RPLALWRS TFA 99.04% Unkown
HY-161169 TP0628103 Inhibitor / Unkown
HY-181769 Anticancer agent 306 / Unkown
HY-184162 HSP110-IN-1 / Unkown
HY-P3123 Dnp-RPLALWRS / Unkown
HY-P3699 TNO003 Substrate / Unkown
HY-P4931A Mca-KPLGL-Dap(Dnp)-AR-NH2 TFA / Unkown
HY-RS08551 MMP7 Human Pre-designed siRNA Set A / Unkown
HY-RS08553 Mmp7 Rat Pre-designed siRNA Set A / Unkown
HY-P3699A TNO003 TFA Substrate / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mmp7 NCBI NCBI:4316