2. Gene
  3. Plk1 - polo-like kinase 1 Gene

Plk1 - polo-like kinase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Plk

Gene ID: 25515 | Gene type: protein coding

About Plk1

Primary_assembly 1: 176,716,420-176,726,400 forward strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 186 orthologues, 4 paralogues and is associated with 10 phenotypes. Biased expression in Thymus (RPKM 13.3), Spleen (RPKM 69.1) and 8 other tissues.

Summary

Predicted to enable several functions, including ATP binding activity; anaphase-promoting complex binding activity; and magnesium ion binding activity. Involved in polar body extrusion after meiotic divisions and response to Antibiotic. Acts upstream of or within protein phosphorylation. Located in cytoplasm; nucleus; and spindle. Human ortholog(s) of this gene implicated in urinary bladder Cancer. Orthologous to human PLK1 (polo like kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Plk1 Products(1)

mRNA Protein Name
NM_017100.2 NP_058796.2 serine/threonine-protein kinase PLK1

Plk1 Protein Structure

STKc_PLK1

STKc_PLK1: cd14187 (44 - 308)

POLO_box_1

POLO_box_1: cd13118 (406 - 493)

POLO_box_2

POLO_box_2: cd13117 (508 - 589)

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  • 603 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PLK1

PLK-1

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12137 Volasertib Inhibitor 99.41% Yes
HY-12137A Volasertib trihydrochloride Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Phase
HY-12037A Rigosertib Inhibitor 98.35% Phase 3
HY-12037 Rigosertib sodium Inhibitor 99.57% Phase 3
HY-50698 BI 2536 Inhibitor 99.95% Phase 2
HY-15828 Onvansertib Inhibitor 99.55% Phase 2
HY-147298 Plogosertib Inhibitor 99.95% Phase 2
HY-50877 GSK461364 Inhibitor 99.82% Phase 1
HY-15160 TAK-960 Inhibitor 99.75% Phase 1
HY-15160B TAK-960 dihydrochloride Inhibitor 99.19% Phase 1
HY-15160A TAK-960 hydrochloride Inhibitor / Phase 1
Pre-clinical Phase
Bioactive Molecules (21)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-11003 GW843682X Inhibitor 99.75% Unkown
HY-15161 Ro3280 Inhibitor 98.87% Unkown
HY-18009 (Z)-LFM-A13 Inhibitor 99.97% Unkown
HY-15155 MLN0905 Inhibitor 99.94% Unkown
HY-108597 TC-S 7005 Inhibitor 99.56% Unkown
HY-12045 HMN-214 Inhibitor 99.25% Unkown
HY-12134 Poloxin Inhibitor 98.01% Unkown
HY-15158 SBE13 Hydrochloride Inhibitor 99.66% Unkown
HY-15159 Cyclapolin 9 Inhibitor 99.16% Unkown
HY-N8692 Dihydrobaicalein Inhibitor 99.94% Unkown
HY-110002 LFM-A13 Inhibitor / Unkown
HY-77195 Poloxime Inhibitor ≥95.0% Unkown
HY-15158A SBE13 Inhibitor / Unkown
HY-158031 PLK1/BRD4-IN-5 Inhibitor / Unkown
HY-149100 PLK1-IN-6 Inhibitor / Unkown
HY-157427 PROTAC PLK1 Degrader-1 Degrader / Unkown
HY-143471 PLK1/BRD4-IN-1 Inhibitor / Unkown
HY-18651 (E/Z)-Rigosertib sodium / Unkown
HY-148974 PLK1-IN-5 Inhibitor / Unkown
HY-115589 YLT-11 Inhibitor / Unkown
HY-112395 BTO-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plk1 NCBI NCBI:5347
Mus musculus Plk1 NCBI NCBI:18817