Plk1 - polo-like kinase 1 Gene

Also Known as Plk

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25515

About Plk1

Primary_assembly 1: 176,716,420-176,726,400 forward strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 186 orthologues, 4 paralogues and is associated with 10 phenotypes. Biased expression in Thymus (RPKM 13.3), Spleen (RPKM 69.1) and 8 other tissues.

Summary

Predicted to enable several functions, including ATP binding activity; anaphase-promoting complex binding activity; and magnesium ion binding activity. Involved in polar body extrusion after meiotic divisions and response to Antibiotic. Acts upstream of or within protein phosphorylation. Located in cytoplasm; nucleus; and spindle. Human ortholog(s) of this gene implicated in urinary bladder Cancer. Orthologous to human PLK1 (polo like kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Plk1 Products (1)

mRNA Protein Name
NM_017100.2 NP_058796.2 serine/threonine-protein kinase PLK1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in polar body extrusion after meiotic divisions IMP
IMP: Inferred from mutant phenotype
12784254 RGD
acts upstream of or within protein phosphorylation IGI
IGI: Inferred from genetic interaction
19638580 RGD
Cellular Component GO Annotation Evidence References Source
located in spindle midzone IDA
IDA: Inferred from direct assay
12784254 RGD
located in spindle pole IDA
IDA: Inferred from direct assay
12784254 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Plk1 Protein Structure

STKc_PLK1

STKc_PLK1: cd14187 (44 - 308)

POLO_box_1

POLO_box_1: cd13118 (406 - 493)

POLO_box_2

POLO_box_2: cd13117 (508 - 589)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 603 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PLK1

  • PLK-1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12137A Volasertib trihydrochloride Inhibitor 99.12% Yes

Clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-12137 Volasertib Inhibitor 99.97% Phase 3
HY-12037 Rigosertib sodium Inhibitor 99.57% Phase 3
HY-15828 Onvansertib Inhibitor 99.86% Phase 2
HY-147298 Plogosertib Inhibitor 98.59% Phase 2
HY-50877 GSK461364 Inhibitor 99.82% Phase 1
HY-15160 TAK-960 Inhibitor 99.75% Phase 1
HY-12045 HMN-214 Inhibitor 99.94% Phase 1

Pre-clinical Phase

Bioactive Molecules (51)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-50698 BI 2536 Inhibitor 99.95% Unkown
HY-12037A Rigosertib Inhibitor 99.01% Unkown
HY-100789 ON1231320 Inhibitor 99.90% Unkown
HY-11003 GW843682X Inhibitor 99.89% Unkown
HY-15161 Ro3280 Inhibitor 99.46% Unkown
HY-15155 MLN0905 Inhibitor 99.94% Unkown
HY-W286743 Nε-(Carboxymethyl)-L-lysine Activator 99.70% Unkown
HY-108597 TC-S 7005 Inhibitor 99.68% Unkown
HY-12134 Poloxin Inhibitor 98.05% Unkown
HY-N0885 Telocinobufagin Inhibitor 99.93% Unkown
HY-150259 MDEG-541 Degrader 98.68% Unkown
HY-15158 SBE13 Hydrochloride Inhibitor 98.56% Unkown
HY-123467 Lasiokaurin Inhibitor 99.68% Unkown
HY-158031 PLK1/BRD4-IN-5 Inhibitor 98.80% Unkown
HY-18009 (Z)-LFM-A13 Inhibitor 99.80% Unkown
HY-179560 PMV6-PEG4-BI2536 Inhibitor 98.47% Unkown
HY-110002 LFM-A13 Inhibitor 99.65% Unkown
HY-15159 Cyclapolin 9 Inhibitor 98.09% Unkown
HY-160558 PLK1/BRD4-IN-3 Inhibitor 98.55% Unkown
HY-N8692 Dihydrobaicalein Inhibitor 99.94% Unkown
HY-173212 PLK1-IN-13 Inhibitor 98.02% Unkown
HY-149100 PLK1-IN-6 Inhibitor 99.60% Unkown
HY-15160B TAK-960 dihydrochloride Inhibitor 99.15% Unkown
HY-77195 Poloxime Inhibitor 95.0% Unkown
HY-180989 PROTAC PLK1 Degrader-2 Degrader 99.48% Unkown
HY-169579 PLK1-IN-11 Inhibitor 99.52% Unkown
HY-15158A SBE13 Inhibitor / Unkown
HY-W162436 MCC1019 Inhibitor / Unkown
HY-N13795 3,4,3'-Tri-O-methylflavellagic acid Inhibitor / Unkown
HY-181001 POI ligand-4 Degrader / Unkown
HY-148974 PLK1-IN-5 Inhibitor / Unkown
HY-208742 ZNL-02-096 Inhibitor / Unkown
HY-112395 BTO-1 Inhibitor / Unkown
HY-172880 PLK1-IN-15 Inhibitor / Unkown
HY-161521 PLK1-IN-10 Inhibitor / Unkown
HY-173233 PLK1-IN-14 Inhibitor / Unkown
HY-181769 Anticancer agent 306 Inhibitor / Unkown
HY-18651 (E/Z)-Rigosertib sodium / Unkown
HY-180990 POI ligand-3 Inhibitor / Unkown
HY-172364 PLK1-IN-12 Inhibitor / Unkown
HY-143471 WNY0824 Inhibitor / Unkown
HY-181000 PROTAC PLK1 Degrader-3 Degrader / Unkown
HY-115589 YLT-11 Inhibitor / Unkown
HY-50698A (S)-BI 2536 Inhibitor / Unkown
HY-111090 GSK461364 analogue 1 Inhibitor / Unkown
HY-181030 BDE30671203 Inhibitor / Unkown
HY-172677 IIP0943 Inhibitor / Unkown
HY-184863 PLK1-IN-17 Inhibitor / Unkown
HY-183427 KBJK557 Inhibitor / Unkown
HY-181051 PLK1-IN-16 Inhibitor / Unkown
HY-15160A TAK-960 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plk1 NCBI NCBI:5347