Map2 - microtubule-associated protein 2 Gene

Also Known as MAP2R; Mtap2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25595

Summary

Enables actin binding activity; microtubule binding activity; and protein kinase binding activity. Involved in several processes, including negative regulation of cellular component organization; positive regulation of vesicle transport along microtubule; and response to progesterone. Located in several cellular components, including axon; dendrite; and endoplasmic reticulum. Part of protein-containing complex. Used to study Alzheimer's disease and cerebral infarction. Biomarker of arteriovenous malformation; asphyxia neonatorum; brain ischemia; sciatic neuropathy; and temporal lobe epilepsy. Orthologous to human MAP2 (microtubule associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Map2 Products (1)

mRNA Protein Name
NM_013066.1 NP_037198.1 microtubule-associated protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin binding IMP
IMP: Inferred from mutant phenotype
11029056 RGD
enables microtubule binding IMP
IMP: Inferred from mutant phenotype
11029056 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15623521 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
2561973 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of axon extension IMP
IMP: Inferred from mutant phenotype
28426968 RGD
involved in negative regulation of microtubule depolymerization IMP
IMP: Inferred from mutant phenotype
11029056 RGD
involved in negative regulation of microtubule polymerization IMP
IMP: Inferred from mutant phenotype
28426968 RGD
involved in positive regulation of anterograde dense core granule transport IMP
IMP: Inferred from mutant phenotype
28426968 RGD
involved in positive regulation of anterograde synaptic vesicle transport IMP
IMP: Inferred from mutant phenotype
28426968 RGD
involved in regulation of organelle transport along microtubule IMP
IMP: Inferred from mutant phenotype
28426968 RGD
involved in regulation of protein localization IMP
IMP: Inferred from mutant phenotype
28426968 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
21683086 RGD
involved in response to progesterone IEP
IEP: Inferred from expression pattern
21683086 RGD
Cellular Component GO Annotation Evidence References Source
located in actin cytoskeleton IMP
IMP: Inferred from mutant phenotype
11029056 RGD
located in apical distal dendrite IDA
IDA: Inferred from direct assay
3517689 RGD
located in axon hillock IDA
IDA: Inferred from direct assay
3517689 RGD
located in axon initial segment IDA
IDA: Inferred from direct assay
28426968 RGD
located in basal dendrite IDA
IDA: Inferred from direct assay
3517689 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
2509111 RGD
located in cytoplasm IMP
IMP: Inferred from mutant phenotype
11029056 RGD
located in dendrite IDA
IDA: Inferred from direct assay
10712642 RGD
located in dendrite cytoplasm IDA
IDA: Inferred from direct assay
3517689 RGD
located in dendritic branch IDA
IDA: Inferred from direct assay
3835499 RGD
located in dendritic filopodium IDA
IDA: Inferred from direct assay
3517689 RGD
located in dendritic growth cone IDA
IDA: Inferred from direct assay
3517689 RGD
located in dendritic shaft IDA
IDA: Inferred from direct assay
3835499 RGD
located in distal dendrite IDA
IDA: Inferred from direct assay
3835499 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
2743390 RGD
NOT located in main axon IDA
IDA: Inferred from direct assay
3517689 RGD
located in microtubule cytoskeleton IMP
IMP: Inferred from mutant phenotype
11029056 RGD
located in neuron projection IDA
IDA: Inferred from direct assay
21119615 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
3835499 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
2743390 RGD
located in primary dendrite IDA
IDA: Inferred from direct assay
3835499 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
15623521 RGD
located in proximal dendrite IDA
IDA: Inferred from direct assay
3835499 RGD
located in proximal neuron projection IDA
IDA: Inferred from direct assay
28426968 RGD
located in ruffle membrane IMP
IMP: Inferred from mutant phenotype
11029056 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

microtubule-associated protein 2

  • MAP-2

  • microtubule-associated protein 2C

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-107116 MAP4343 99.67% Phase 2

Pre-clinical Phase

Bioactive Molecules (37)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136848 SM1-71 Inhibitor 96.09% Unkown
HY-159190 HRX-0233 Inhibitor 98.92% Unkown
HY-171178 DK2403 98.24% Unkown
HY-D2415 BODIPY-FL staurosporine 95.4% Unkown
HY-RS08350 METAP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16235 Map2k4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-107116S MAP4343-d4 / Unkown
HY-163880 EGFR-IN-119 Inhibitor / Unkown
HY-168857 GSK-3β inhibitor 24 / Unkown
HY-181926 COX-2/HDAC6-IN-1 / Unkown
HY-184145 AKT1-IN-13 / Unkown
HY-E70842 MAP2K1 L115P Recombinant Human Active Protein Kinase / Unkown
HY-E70843 MAP2K1 P124L Recombinant Human Active Protein Kinase / Unkown
HY-E70844 MAP2K2 Recombinant Human Active Protein Kinase / Unkown
HY-P3894 P34cdc2 Kinase Fragment Modulator / Unkown
HY-RS08032 MAP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08033 MAP2K1 Human Pre-designed siRNA Set A / Unkown
HY-RS08034 Map2k1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08035 Map2k1 Rat Pre-designed siRNA Set A / Unkown
HY-RS08036 MAP2K2 Human Pre-designed siRNA Set A / Unkown
HY-RS08037 Map2k2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08038 Map2k2 Rat Pre-designed siRNA Set A / Unkown
HY-RS08039 MAP2K3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08040 MAP2K4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08041 MAP2K5 Human Pre-designed siRNA Set A / Unkown
HY-RS08042 Map2k5 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08043 Map2k5 Rat Pre-designed siRNA Set A / Unkown
HY-RS08044 MAP2K6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08045 MAP2K7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08160 MASP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17292 Map2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17782 Map2k6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18959 Neu1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19790 Map2k7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23747 Map2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24249 Map2k6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26286 Map2k7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map2 NCBI NCBI:4133