Pcna - proliferating cell nuclear antigen Gene

Also Known as PCNAR; Pcna/cyclin

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25737

Summary

Enables Estrogen receptor binding activity. Involved in several processes, including estrous cycle; liver regeneration; and response to dexamethasone. Located in nucleus. Biomarker of several diseases, including brain ischemia (multiple); mucositis; obstructive jaundice; osteoporosis; and sciatic neuropathy. Human ortholog(s) of this gene implicated in stomach Cancer. Orthologous to human PCNA (proliferating cell nuclear antigen). [provided by Alliance of Genome Resources, Apr 2022]

Pcna Products (1)

mRNA Protein Name
NM_022381.3 NP_071776.1 proliferating cell nuclear antigen

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nuclear estrogen receptor binding IPI
IPI: Inferred from physical interaction
19683557 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
7729533 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to UV IEP
IEP: Inferred from expression pattern
8905661 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
16179908 RGD
involved in estrous cycle IEP
IEP: Inferred from expression pattern
10856886 RGD
involved in heart development IEP
IEP: Inferred from expression pattern
12389741 RGD
involved in liver regeneration IEP
IEP: Inferred from expression pattern
7906221 RGD
involved in response to L-glutamate IEP
IEP: Inferred from expression pattern
12917765 RGD
involved in response to cadmium ion IEP
IEP: Inferred from expression pattern
15638412 RGD
involved in response to dexamethasone IEP
IEP: Inferred from expression pattern
16638911 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
10856886 RGD
involved in response to lipid IDA
IDA: Inferred from direct assay
19825967 RGD
involved in response to oxidative stress IEP
IEP: Inferred from expression pattern
12969989 RGD
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
8837726 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

proliferating cell nuclear antigen

  • cyclin

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-N0095 (S)-10-Hydroxycamptothecin 99.74% Phase 2
HY-160700 TNG348 Inhibitor 99.74% Phase 2

Pre-clinical Phase

Bioactive Molecules (29)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0692 Schisandrol B 99.92% Unkown
HY-NP199 Bovine pituitary extract Modulator / Unkown
HY-110111 T2AA 99.04% Unkown
HY-P4322 H-Ile-Lys-Val-Ala-Val-OH Activator 99.35% Unkown
HY-120836 AOH1160 98.56% Unkown
HY-153365 I-138 Inhibitor 99.75% Unkown
HY-17522 Meptyldinocap 99.91% Unkown
HY-124012 PCNA-I1 98.78% Unkown
HY-B1866 Linuron Antagonist 99.88% Unkown
HY-13338 Mabuterol Agonist 99.96% Unkown
HY-200129 PCNA-IN-1 Inhibitor 98.30% Unkown
HY-125576 Griselimycin Inhibitor 98.3% Unkown
HY-117171 Proquinazid / Unkown
HY-123715 Anticancer agent 255 / Unkown
HY-163691 Antitumor agent-163 Inhibitor / Unkown
HY-180216 USP1-IN-15 Inhibitor / Unkown
HY-180585 LOXL2/sGC modulator-2 / Unkown
HY-183363 USP1-IN-17 Inhibitor / Unkown
HY-183488 R9-caPep / Unkown
HY-183581 USP1-IN-18 Inhibitor / Unkown
HY-184385 PI3K/AKT/JAK2-IN-1 Inhibitor / Unkown
HY-P10825 p21PBP Inhibitor / Unkown
HY-RS10159 PCNA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-110111A T2AA hydrochloride Inhibitor / Unkown
HY-117846 MLAF50 Agonist / Unkown
HY-152051S Mabuterol-d9 hydrochloride Agonist / Unkown
HY-RS16672 Pcna Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23107 Pcna Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W755295 Mabuterol hydrochloride Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pcna NCBI NCBI:5111