SS18L1 - SS18L1 subunit of BAF chromatin remodeling complex Gene

Also Known as CREST; LP2261; SMARCL2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26039

Summary

This gene encodes a calcium-responsive transactivator which is an essential subunit of a neuron-specific chromatin-remodeling complex. The structure of this gene is similar to that of the SS18 gene. Mutations in this gene are involved in Amyotrophic Lateral Sclerosis (ALS). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
Ubiquitous expression in skin (RPKM 3.8), brain (RPKM 3.7) and 25 other tissues.

SS18L1 Products (1)

mRNA Protein Name
NG_034255.1 [RefSeqGene]

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Cellular Component GO Annotation Evidence References Source
located in kinetochore IDA
IDA: Inferred from direct assay
18331714 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SS18L1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SS18L1 O75177 LGALS3 Homo sapiens Q6NVH9
Validated Y2H
25416956
Intra
SS18L1 O75177 SNRPC Homo sapiens Q5TAL4
Y2H Prey Pooling
25416956
Intra
SS18L1 O75177 SNRPC Homo sapiens Q5TAL4
Y2H Array
25416956
Intra
SS18L1 O75177 MIA2 Homo sapiens Q96PC5
Validated Y2H
25416956
Intra
SS18L1 O75177 LGALS3 Homo sapiens P17931
Validated Y2H
25416956
Intra
SS18L1 O75177 SF3B4 Homo sapiens Q15427
Validated Y2H
25416956
Intra
SS18L1 O75177 SF3B4 Homo sapiens Q15427
Y2H Array
25416956
Intra
SS18L1 O75177 SF3B4 Homo sapiens Q15427
Y2H Pooling
16189514
Intra
SS18L1 O75177 SNRPB Homo sapiens P14678-2
Validated Y2H
25416956
Intra
SS18L1 O75177 CSTF2 Homo sapiens P33240
Validated Y2H
25416956
Intra
SS18L1 O75177 CSTF2 Homo sapiens P33240
Y2H Prey Pooling
25416956
Intra
SS18L1 O75177 CSTF2 Homo sapiens P33240
Y2H Array
25416956
Intra
SS18L1 O75177 FAM168A Homo sapiens Q92567
Y2H
21516116
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148739 dBRD 9-A 99.50% Unkown