WIPI2 - WD repeat domain, phosphoinositide interacting 2 Gene

Also Known as Atg21; ATG18B; CGI-50; IDDSSA; WIPI-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26100

About WIPI2

Cytogenetic location: 7p22.1 Genomic coordinates (GRCh38): 7:5,190,233-5,233,855 (from NCBI)

This gene has 14 transcripts (splice variants), 223 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 20.8), brain (RPKM 12.7) and 25 other tissues.

Summary

WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with Phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008]

WIPI2 Products (6)

mRNA	Protein	Name
NM_001033518.2	NP_001028690.1	WD repeat domain phosphoinositide-interacting protein 2 isoform c
NM_001033519.2	NP_001028691.1	WD repeat domain phosphoinositide-interacting protein 2 isoform d
NM_001033520.1	NP_001028692.1	WD repeat domain phosphoinositide-interacting protein 2 isoform e
NM_001278299.2	NP_001265228.1	WD repeat domain phosphoinositide-interacting protein 2 isoform f
NM_015610.4	NP_056425.1	WD repeat domain phosphoinositide-interacting protein 2 isoform a
NM_016003.4	NP_057087.2	WD repeat domain phosphoinositide-interacting protein 2 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables phosphatidylinositol-3,5-bisphosphate binding	IDA IDA: Inferred from direct assay	20505359	GOA
enables phosphatidylinositol-3-phosphate binding	IDA IDA: Inferred from direct assay	20505359	GOA
enables phosphatidylinositol-5-phosphate binding	IDA IDA: Inferred from direct assay	25578879	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in autophagosome assembly	IDA IDA: Inferred from direct assay	28890335	GOA
involved in autophagosome assembly	IMP IMP: Inferred from mutant phenotype	20505359	GOA
NOT involved in autophagosome maturation	IMP IMP: Inferred from mutant phenotype	20505359	GOA
involved in cellular response to starvation	IDA IDA: Inferred from direct assay	28561066	GOA
involved in protein localization to phagophore assembly site	IMP IMP: Inferred from mutant phenotype	28561066	GOA

Cellular Component GO Annotation	Evidence	References	Source
NOT colocalizes with autophagosome	IDA IDA: Inferred from direct assay	20505359	GOA
located in cytosol	IDA IDA: Inferred from direct assay	20505359	GOA
colocalizes with membrane	IDA IDA: Inferred from direct assay	25578879	GOA
located in phagophore assembly site	IDA IDA: Inferred from direct assay	22456507	GOA
located in phagophore assembly site membrane	IDA IDA: Inferred from direct assay	20505359	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WIPI2 Protein Structure

WD40

0
100
200
300
400
454 a.a.

Protein Preferred Names	Protein Names
WD repeat domain phosphoinositide-interacting protein 2	WD40 repeat protein interacting with phosphoinositides 2

WIPI2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	WIPI2	Q9Y4P8	ARL6IP1	Homo sapiens	Q15041	Y2H Prey Pooling	25416956
Intra	WIPI2	Q9Y4P8	ARL6IP1	Homo sapiens	Q15041	Y2H Array	25416956
Intra	WIPI2	Q9Y4P8	ARL6IP1	Homo sapiens	Q15041	Validated Y2H	25416956
Intra	WIPI2	Q9Y4P8	POT1	Homo sapiens	Q9NUX5	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

WIPI2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811199	WIPI2 Antibody	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder With Short Stature And Variable Skeletal Anomalies	IDDSSA
Neurodegeneration With Brain Iron Accumulation	Nbia Neurodegeneration With Brain Iron Accumulation Disorders Neurodegeneration, With Brain Iron Accumulation
Neurodegeneration With Brain Iron Accumulation 5	NBIA5 Beta-Propeller Protein-Associated Neurodegeneration Bpan Static Encephalopathy Of Childhood With Neurodegeneration In Adulthood Senda Neurodegeneration With Brain Iron Accumulation Type 5 Neurodegeneration With Brain Iron Accululation 5 Static Encephalopathy Of Childhood With Neurdegeneration In Adulthood Neurodegeneration, With Brain Iron Accululation, Type 5
Intracranial Arteriosclerosis
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15820	WIPI2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21084	Wipi2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27602	Wipi2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	WIPI2	VGNC	VGNC:36943
Rattus norvegicus	WIPI2	RGD	RGD:1359154
Felis catus	WIPI2	VGNC	VGNC:67075
Macaca mulatta	WIPI2	VGNC	VGNC:79918
Mus musculus	WIPI2	MGD	MGI:1923831
Canis familiaris	WIPI2	VGNC	VGNC:48413
Others	WIPI2	NCBI