CFTR - CF transmembrane conductance regulator Gene

Species: Bos taurus

Gene Type: protein coding
Gene ID: 281067

About CFTR

Primary_assembly 4: 50,743,789-50,957,593 reverse strand.ARS-UCD1.2:CM008171.2

This gene has 2 transcripts (splice variants), 215 orthologues and 29 paralogues.

CFTR Products (1)

mRNA Protein Name
NM_174018.2 NP_776443.1 cystic fibrosis transmembrane conductance regulator

CFTR Protein Structure

CFTR_protein

CFTR_protein: cl36858 (0 - 1468)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1481 a.a.
Protein Preferred Names Protein Names

cystic fibrosis transmembrane conductance regulator

  • ATP-binding cassette sub-family C member 7

  • ATP-binding cassette transporter sub-family C member 7

  • cAMP-dependent chloride channel

  • channel conductance-controlling ATPase

  • cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15206 Glibenclamide Inhibitor 99.83% Yes
HY-13017 Ivacaftor Agonist 99.97% Yes
HY-B1125 Glucosamine 98.0% Yes
HY-15448 Tezacaftor Modulator 99.94% Yes
HY-111772 Elexacaftor Modulator 99.26% Yes
HY-13262 Lumacaftor Modulator 99.85% Yes
HY-14832 Ataluren Inhibitor 99.41% Yes
HY-B0679 Lubiprostone Activator 99.09% Yes
HY-13017S Ivacaftor-d9 Activator 99.79% Unkown
HY-B1153 Glafenine Activator 98.77% Unkown
HY-106203 Crinecerfont Antagonist 98.08% Unkown
HY-B1153A Glafenine hydrochloride Activator 99.03% Unkown
HY-B1153R Glafenine (Standard) Activator 98.59% Unkown
HY-13017A Ivacaftor benzenesulfonate Agonist / Unkown
HY-13017B Ivacaftor hydrate Agonist / Unkown
HY-15206R Glibenclamide (Standard) Inhibitor / Unkown
HY-106203R Crinecerfont (Standard) Antagonist / Unkown

Clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Phase
HY-15206A Glibenclamide potassium Inhibitor / Phase 4
HY-106203A Crinecerfont hydrochloride Antagonist 98.82% Phase 3
HY-15448S Tezacaftor-d4 Modulator 98.95% Phase 3
HY-106203C Crinecerfont tosylate Antagonist / Phase 3
HY-145603 Vanzacaftor Modulator 98.72% Phase 2
HY-109177 Icenticaftor Activator 99.66% Phase 2
HY-18337 IOWH-032 Inhibitor 99.63% Phase 2
HY-111680 Nesolicaftor Modulator 99.37% Phase 2
HY-109152 Navocaftor Modulator 99.20% Phase 2
HY-109187A Posenacaftor sodium Modulator 99.69% Phase 2
HY-126394 Bamocaftor Modulator 99.09% Phase 2
HY-109027 Cavosonstat Modulator 99.36% Phase 2
HY-125381 CFTR corrector 2 Modulator 98.92% Phase 2
HY-109187 Posenacaftor Modulator / Phase 2

Pre-clinical Phase

Bioactive Molecules (83)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16671 CFTR(inh)-172 Inhibitor 99.80% Unkown
HY-150090 SRI-41315 Activator 99.68% Unkown
HY-108575 Chromanol 293B Inhibitor 99.2% Unkown
HY-19778 (R)-BPO-27 Inhibitor 99.94% Unkown
HY-18336 GlyH-101 Inhibitor 99.68% Unkown
HY-N6818 5,​7,​4'-​Trimethoxyflavone Activator 99.65% Unkown
HY-N2057 Steviol Inhibitor 99.85% Unkown
HY-12129 CP 154526 hydrochloride Antagonist 99.76% Unkown
HY-145603A (R)-Vanzacaftor Modulator 98.02% Unkown
HY-115878 NJH-2-057 Modulator 98.84% Unkown
HY-111099 GLPG1837 Agonist 99.87% Unkown
HY-14179 PPQ-102 Inhibitor 99.73% Unkown
HY-15206S1 Glyburide-d3 Inhibitor 99.64% Unkown
HY-158002 IDOR-4 Modulator 96.98% Unkown
HY-P1106A K41498 TFA Antagonist 98.71% Unkown
HY-111111 Galicaftor Modulator 98.56% Yes
HY-150089 SRI-37240 Modulator 98.29% Unkown
HY-152264 CFTR activator 1 Activator 99.94% Unkown
HY-158991 I1421 Agonist 99.15% Unkown
HY-119229 VRT-325 Modulator 99.15% Unkown
HY-111772A (R)-Elexacaftor Modulator 99.44% Unkown
HY-13017S3 Ivacaftor-d4 Agonist 97.32% Unkown
HY-19778A BPO-27 racemate Inhibitor 98.50% Unkown
HY-112267 Olacaftor Modulator 99.60% Unkown
HY-143344 NJH-2-056 Modulator 98.31% Unkown
HY-136939 CFTR corrector 6 Activator 98.15% Unkown
HY-15206S Glyburide-d11 Inhibitor 99.39% Unkown
HY-13017S2 Ivacaftor-d18 92.92% Unkown
HY-19970 KM11060 Activator 98.71% Unkown
HY-119936 GLPG2451 Activator 99.68% Unkown
HY-164000 CFTR corrector 15 Modulator 99.67% Unkown
HY-13017S1 Ivacaftor-d19 Agonist 98.10% Unkown
HY-155742 CFTR corrector 12 Modulator 99.85% Unkown
HY-15448A (Rac)-Tezacaftor Modulator 96.30% Unkown
HY-117187 Corr4A Modulator 99.58% Unkown
HY-145603S Vanzacaftor-d4 / Unkown
HY-135279 CFTR corrector 4 Modulator 99.72% Unkown
HY-W984122 CFTR corrector 17 Modulator 98.05% Unkown
HY-N5101 Kobusin Activator 99.93% Unkown
HY-109187B (R)-Posenacaftor sodium Inhibitor 98.96% Unkown
HY-103369 PG01 Activator 98.04% Unkown
HY-153911 H2-Gamendazole 98.20% Unkown
HY-147249 CFTR corrector 8 Modulator 95.86% Unkown
HY-119179 UCCF-853 Modulator 99.93% Unkown
HY-133013 GLPG-3221 / Unkown
HY-N6818R 5,​7,​4'-​Trimethoxyflavone (Standard) Activator / Unkown
HY-P10806 kCAL01 Inhibitor / Unkown
HY-P3597 Urocortin III (mouse) free acid Agonist / Unkown
HY-112267A (R)-Olacaftor Modulator 98.07% Unkown
HY-177313 AAG561 Antagonist / Unkown
HY-158144 GLPG2737 Modulator / Unkown
HY-161753 CFTR potentiator 1 Activator / Unkown
HY-164037 Riselcaftor Modulator / Unkown
HY-114725 VRT-532 Modulator 98.98% Unkown
HY-174821 VU439 Modulator / Unkown
HY-116806 AF-2785 Inhibitor / Unkown
HY-14832S Ataluren-d4 Inhibitor / Unkown
HY-161895 CFTR corrector 14 Modulator / Unkown
HY-156522 CRF1 receptor antagonist-1 Antagonist / Unkown
HY-145126 CP-628006 Activator / Unkown
HY-148806 Zatonacaftor Modulator / Unkown
HY-165407 Neltenexine / Unkown
HY-185122 MS6178 Activator / Unkown
HY-169000 CFTR corrector 16 Modulator / Unkown
HY-112363 Aloisine A Activator / Unkown
HY-161894 CFTR corrector 13 Modulator / Unkown
HY-133569 ARN23765 Modulator / Unkown
HY-183725 MS5128 Modulator / Unkown
HY-172555 CFTR corrector 18 Modulator / Unkown
HY-106203B (R)-Crinecerfont Antagonist / Unkown
HY-126394B Bamocaftor potassium Modulator / Unkown
HY-147315 CFTR corrector 9 Modulator 98.84% Unkown
HY-P10226 PGD97 Activator / Unkown
HY-B0679S Lubiprostone-d7 Activator / Unkown
HY-15448S1 Tezacaftor-d6 Modulator / Unkown
HY-153133 CFTR corrector 11 Modulator 99.80% Unkown
HY-169536 CFTR activator 2 Activator 99.54% Unkown
HY-134385 6-PhEt-dATP / Unkown
HY-14832S1 Ataluren-13C6 Inhibitor / Unkown
HY-B1125S Glucosamine-13C6 / Unkown
HY-15206S2 Glibenclamide-13C6 Inhibitor / Unkown
HY-13017S4 Ivacaftor-13C6 Agonist / Unkown
HY-183001 ATX-012 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens CFTR NCBI NCBI:1080