2. Gene
  3. Bace2 - beta-secretase 2 Gene

Bace2 - beta-secretase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 288227 | Gene type: protein coding

About Bace2

Primary_assembly 11: 36,707,458-36,789,546 forward strand.mRatBN7.2:CM026984.1

This gene has 1 transcript (splice variant), 215 orthologues, 8 paralogues and is associated with 5 phenotypes. Biased expression in Spleen (RPKM 61.5), Lung (RPKM 44.1) and 9 other tissues.

Summary

Predicted to enable aspartic-type endopeptidase activity. Involved in astrocyte activation. Located in dense core granule. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human BACE2 (Beta-secretase 2). [provided by Alliance of Genome Resources, Apr 2022]

Bace2 Products(1)

mRNA Protein Name
NM_001002802.2 NP_001002802.1 beta-secretase 2 precursor

Bace2 Protein Structure

beta_secretase_like

beta_secretase_like: cd05473 (84 - 445)

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  • 514 a.a.
Protein Preferred Names Protein Names

beta-secretase 2

beta-site APP-cleaving enzyme 2

beta-site amyloid precursor protein cleaving enzyme 2

memapsin-1

membrane-associated aspartic protease 1

theta-secretase

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-16759 Verubecestat Inhibitor 99.56% Phase 3
Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-136742 BACE2-IN-1 Inhibitor 99.34% Unkown
HY-161359 BACE1-IN-14 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bace2 NCBI NCBI:25825
Mus musculus Bace2 NCBI NCBI:56175