Bace2 - beta-secretase 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 288227

About Bace2

Primary_assembly 11: 36,707,458-36,789,546 forward strand.mRatBN7.2:CM026984.1

This gene has 1 transcript (splice variant), 215 orthologues, 8 paralogues and is associated with 5 phenotypes. Biased expression in Spleen (RPKM 61.5), Lung (RPKM 44.1) and 9 other tissues.

Summary

Predicted to enable aspartic-type endopeptidase activity. Involved in astrocyte activation. Located in dense core granule. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human BACE2 (Beta-secretase 2). [provided by Alliance of Genome Resources, Apr 2022]

Bace2 Products (1)

mRNA Protein Name
NM_001002802.2 NP_001002802.1 beta-secretase 2 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in astrocyte activation IEP
IEP: Inferred from expression pattern
21073551 RGD
Cellular Component GO Annotation Evidence References Source
located in dense core granule IDA
IDA: Inferred from direct assay
19117266 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bace2 Protein Structure

beta_secretase_like

beta_secretase_like: cd05473 (84 - 445)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 514 a.a.
Protein Preferred Names Protein Names

beta-secretase 2

  • beta-site APP-cleaving enzyme 2

  • beta-site amyloid precursor protein cleaving enzyme 2

  • memapsin-1

  • membrane-associated aspartic protease 1

  • theta-secretase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-16759 Verubecestat Inhibitor 99.56% Phase 3

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136742 BACE2-IN-1 Inhibitor 99.4% Unkown
HY-124322 NB-360 Inhibitor 99.08% Unkown
HY-12938 AMG-8718 Inhibitor / Unkown
HY-161359 BACE1-IN-14 Inhibitor / Unkown
HY-147758 BACE1/2-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bace2 NCBI NCBI:25825