Nod2 - nucleotide-binding oligomerization domain containing 2 Gene

Also Known as Card15

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 291912

About Nod2

Primary_assembly 19: 18,382,439-18,417,177 reverse strand.mRatBN7.2:CM026992.1

This gene has 2 transcripts (splice variants), 167 orthologues, 21 paralogues and is associated with 62 phenotypes. Biased expression in Spleen (RPKM 4.7), Adrenal (RPKM 4.1) and 7 other tissues.

Summary

Enables muramyl dipeptide binding activity. Involved in several processes, including cellular response to peptidoglycan; positive regulation of dendritic cell cytokine production; and response to muramyl dipeptide. Located in cytoplasm. Biomarker of colitis; middle cerebral artery infarction; and pancreatitis. Human ortholog(s) of this gene implicated in several diseases, including Blau syndrome; autoimmune disease (multiple); gastrointestinal carcinoma; intestinal disease (multiple); and lung disease (multiple). Orthologous to human NOD2 (nucleotide binding oligomerization domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Nod2 Products (1)

mRNA Protein Name
NM_001106172.2 NP_001099642.1 nucleotide-binding oligomerization domain-containing protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables muramyl dipeptide binding IDA
IDA: Inferred from direct assay
16973131 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
20863826 RGD
involved in cellular response to peptidoglycan IEP
IEP: Inferred from expression pattern
24169446 RGD
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
16254493 RGD
involved in positive regulation of dendritic cell cytokine production IDA
IDA: Inferred from direct assay
16818757 RGD
involved in response to muramyl dipeptide IDA
IDA: Inferred from direct assay
16973131 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
21057821 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nod2 Protein Structure

DD

DD: cl14633 (6 - 86)

DD

DD: cl14633 (106 - 185)

NACHT

NACHT: pfam05729 (265 - 435)

NOD2_WH

NOD2_WH: pfam17779 (517 - 573)

NLRC4_HD2

NLRC4_HD2: cl39284 (575 - 728)

PPP1R42

PPP1R42: cl42388 (751 - 983)

LRR_RI

LRR_RI: sd00033 (785 - 815)

LRR_RI

LRR_RI: sd00033 (816 - 843)

LRR_RI

LRR_RI: sd00033 (844 - 871)

LRR_RI

LRR_RI: sd00033 (872 - 899)

LRR_RI

LRR_RI: sd00033 (900 - 927)

LRR_RI

LRR_RI: sd00033 (928 - 952)

LRR_RI

LRR_RI: sd00033 (956 - 977)

LRR_RI

LRR_RI: sd00033 (978 - 1005)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1012 a.a.
Protein Preferred Names Protein Names

nucleotide-binding oligomerization domain-containing protein 2

  • caspase recruitment domain family, member 15

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-13682 Mifamurtide 99.58% Unkown
HY-13682B Mifamurtide sodium 99.92% Unkown
HY-13682C Mifamurtide TFA 98.0% Unkown

Pre-clinical Phase

Bioactive Molecules (12)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-100691 NOD-IN-1 Inhibitor 99.48% Unkown
HY-147506 NOD2 antagonist 1 Antagonist 99.57% Unkown
HY-168159 TLR7 agonist 27 Agonist / Unkown
HY-168024 NOD1/2-IN-1 Inhibitor / Unkown
HY-146034 NOD1/2 antagonist-1 Antagonist / Unkown
HY-179009 NOD2 agonist 4 Agonist / Unkown
HY-163274 NOD1 antagonist-1 Antagonist / Unkown
HY-176837 NOD2/TLR4 agonist-1 Agonist / Unkown
HY-175348 XB2M54 Inhibitor / Unkown
HY-101927 NOD1/2 antagonist-2 Antagonist / Unkown
HY-123925 CSLP43 Inhibitor / Unkown
HY-168158 NOD2 agonist 3 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nod2 NCBI NCBI:64127