Htt - huntingtin Gene

Also Known as Hd; Hdh

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29424

Summary

Enables signaling receptor binding activity. Involved in several processes, including mRNA transport; negative regulation of cysteine-type endopeptidase activity; and regulation of intracellular mRNA localization. Located in several cellular components, including neuronal cell body; neuronal ribonucleoprotein granule; and postsynaptic density. Used to study Huntington's disease. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in Huntington's disease and Parkinson's disease. Orthologous to human HTT (Huntingtin). [provided by Alliance of Genome Resources, Apr 2022]

Htt Products (1)

mRNA Protein Name
NM_024357.4 NP_077333.2 huntingtin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9454836 RGD
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
12873381 RGD
Biological Process GO Annotation Evidence References Source
involved in mRNA transport IMP
IMP: Inferred from mutant phenotype
22355657 RGD
involved in microtubule depolymerization IMP
IMP: Inferred from mutant phenotype
20858895 RGD
involved in negative regulation of cysteine-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
17124493 RGD
involved in regulation of intracellular mRNA localization IMP
IMP: Inferred from mutant phenotype
20185826 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
22355657 RGD
located in clathrin-coated vesicle IDA
IDA: Inferred from direct assay
20739295 RGD
located in dendrite IDA
IDA: Inferred from direct assay
22355657 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
22355657 RGD
located in neuronal ribonucleoprotein granule IDA
IDA: Inferred from direct assay
22355657 RGD
located in synaptic membrane IDA
IDA: Inferred from direct assay
12650982 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

huntingtin

  • HD protein homolog

  • Huntington disease gene homolog

  • huntingtin (Huntington disease)

  • huntington disease protein homolog

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-132579 Tominersen 96.32% Phase 3
HY-132579A Tominersen sodium 97.36% Phase 2
HY-132593 Rovanersen 94.24% Phase 2
HY-132593A Rovanersen sodium 95.58% Phase 2

Pre-clinical Phase

Bioactive Molecules (20)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-156650 Votoplam Modulator 99.51% Unkown
HY-16009 Buntanetap 99.71% Unkown
HY-136780 SEN177 Inhibitor 98.76% Unkown
HY-156103 mHTT-IN-2 Inhibitor 99.35% Unkown
HY-177360 RNA splicing modulator-4 Inhibitor 99.08% Unkown
HY-16009B Buntanetap L-Tartrate 98.93% Unkown
HY-143792 HTT-D3 / Unkown
HY-150236 FITC-labeled Tominersen sodium Inhibitor 97.65% Unkown
HY-10542A (Z)-GW 5074 Inhibitor / Unkown
HY-156650A Votoplam hydrochloride Modulator / Unkown
HY-175136 Chloroguanabenz acetate Agonist / Unkown
HY-184480 PROTAC HTT Degrader-1 Degrader / Unkown
HY-184481 DHPT-PEG2-C2-NH2 Ligand / Unkown
HY-P10822 ED11 Inhibitor / Unkown
HY-RS06490 HTT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13311 SLC6A4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13312 Slc6a4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W792458 MADAM Ligand / Unkown
HY-RS18021 Htt Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24494 Htt Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Htt NCBI NCBI:3064