Tbk1 - TANK-binding kinase 1 Gene

Predicted to enable several functions, including identical protein binding activity; phosphoprotein binding activity; and protein Phosphatase binding activity. Predicted to be involved in several processes, including positive regulation of defense response; protein phosphorylation; and regulation of gene expression. Predicted to act upstream of or within several processes, including defense response to Gram-positive bacterium; dendritic cell proliferation; and positive regulation of interferon-beta production. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in brain disease and frontotemporal dementia and/or amyotrophic lateral sclerosis-4. Orthologous to human TBK1 (TANK binding kinase 1). [provided by Alliance of Genome Resources, Apr 2022]