Ccr8 - C-C motif chemokine receptor 8 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 301066

About Ccr8

Primary_assembly 8: 119,826,568-119,827,629 forward strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 236 orthologues, 24 paralogues and is associated with 3 phenotypes.

Summary

Predicted to enable C-C chemokine binding activity and C-C Chemokine Receptor activity. Predicted to be involved in several processes, including calcium-mediated signaling; cell chemotaxis; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within chemotaxis. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Biomarker of asthma and pulmonary fibrosis. Orthologous to human CCR8 (C-C motif Chemokine Receptor 8). [provided by Alliance of Genome Resources, Apr 2022]

Ccr8 Products (1)

mRNA Protein Name
XM_008766702.3 XP_008764924.1 C-C chemokine receptor type 8

Ccr8 Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (33 - 308)

7tm_GPCRs

7tm_GPCRs: cd14964 (35 - 59)

7tm_GPCRs

7tm_GPCRs: cd14964 (68 - 89)

7tm_GPCRs

7tm_GPCRs: cd14964 (104 - 126)

7tm_GPCRs

7tm_GPCRs: cd14964 (149 - 165)

7tm_GPCRs

7tm_GPCRs: cd14964 (193 - 216)

7tm_GPCRs

7tm_GPCRs: cd14964 (234 - 256)

7tm_GPCRs

7tm_GPCRs: cd14964 (276 - 301)

  • 0
  • 100
  • 200
  • 300
  • 353 a.a.
Protein Preferred Names Protein Names

C-C chemokine receptor type 8

  • chemokine (C-C motif) receptor 8

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (6)
Cat. No. Product Name Effect
Purity Phase
HY-P990914 Denikitug 99.00% Phase 2
HY-P991481 S-531011 Inhibitor 98.38% Phase 2
HY-P991061 Tagmokitug Inhibitor 99.9% Phase 1
HY-P991942 Lanerkitug Inhibitor 97.00% Phase 1
HY-P991944 ZL-1218 Inhibitor / Phase 1
HY-P991135 Enzelkitug Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-119217 AZ084 Antagonist 99.70% Unkown
HY-122219 R243 Antagonist 98.09% Unkown
HY-124416 ML604086 Inhibitor 99.78% Unkown
HY-121885 LMD-009 Agonist 99.35% Unkown
HY-101038A ZK756326 dihydrochloride Agonist 99.87% Unkown
HY-144197 CCR8 antagonist 1 Antagonist 99.50% Unkown
HY-176800 LMD-902 Agonist / Unkown
HY-176799 LMD-584 Agonist / Unkown
HY-153669 SB-649701 Antagonist / Unkown
HY-184668 CCR8 agonist 2 Agonist / Unkown
HY-160647 CCR8 antagonist 3 Antagonist / Unkown
Inhibitory Antibodies (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991942A Lanerkitug (FUT8-KO) Inhibitor 99.27% Unkown
HY-P991481A S-531011 (FUT8-KO) Inhibitor 99.10% Unkown
HY-P991944A ZL-1218 (FUT8-KO) Inhibitor / Unkown
HY-P992334 CM369 Inhibitor / Unkown
HY-P992365 HFB101110 Inhibitor / Unkown
HY-P991135A Enzelkitug (FUT8-KO) Inhibitor / Unkown
HY-P991782 Anti-Mouse CCR8 Antibody (C8Mab-2) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ccr8 NCBI NCBI:1237