Ccr8 - C-C motif chemokine receptor 8 Gene

Rattus norvegicus

Gene ID: 301066 | Gene type: protein coding

About Ccr8

Primary_assembly 8: 119,826,568-119,827,629 forward strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 236 orthologues, 24 paralogues and is associated with 3 phenotypes.

Summary

Predicted to enable C-C chemokine binding activity and C-C Chemokine Receptor activity. Predicted to be involved in several processes, including calcium-mediated signaling; cell chemotaxis; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within chemotaxis. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Biomarker of asthma and pulmonary fibrosis. Orthologous to human CCR8 (C-C motif Chemokine Receptor 8). [provided by Alliance of Genome Resources, Apr 2022]

Ccr8 Products(1)

mRNA	Protein	Name
XM_008766702.3	XP_008764924.1	C-C chemokine receptor type 8

Ccr8 Protein Structure

7tm_GPCRs

0
100
200
300
353 a.a.

Protein Preferred Names

Protein Names

C-C chemokine receptor type 8

chemokine (C-C motif) receptor 8

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101038A	ZK756326 dihydrochloride	Agonist	99.88%	Unkown
HY-119217	AZ084	Antagonist	99.69%	Unkown
HY-122219	R243	Antagonist	98.01%	Unkown
HY-121885	LMD-009	Agonist	99.76%	Unkown
HY-144197	CCR8 antagonist 1	Antagonist	98.71%	Unkown
HY-144200	CCR8 antagonist 2	Antagonist	99.71%	Unkown
HY-153669	SB-649701	Antagonist	/	Unkown
HY-160647	CCR8 antagonist 3	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ccr8	NCBI	NCBI:1237
Macaca fascicularis	Ccr8	NCBI	NCBI:102132857
Mus musculus	Ccr8	NCBI	NCBI:12776
Macaca mulatta	Ccr8	NCBI	NCBI:693806

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