2. Gene
  3. Gpr119 - G protein-coupled receptor 119 Gene

Gpr119 - G protein-coupled receptor 119 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 302813 | Gene type: protein coding

About Gpr119

Primary_assembly X: 127,852,145-127,858,198 reverse strand.mRatBN7.2:CM026994.1

This gene has 1 transcript (splice variant), 176 orthologues, 18 paralogues and is associated with 2 phenotypes. Biased expression in Brain (RPKM 6.3), Spleen (RPKM 1.1) and 8 other tissues.

Summary

Predicted to enable G protein-coupled receptor activity and phosphatidylcholine binding activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to act upstream of or within Insulin secretion. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human GPR119 (G protein-coupled receptor 119). [provided by Alliance of Genome Resources, Apr 2022]

Gpr119 Products(1)

mRNA Protein Name
NM_181770.1 NP_861435.1 glucose-dependent insulinotropic receptor

Gpr119 Protein Structure

7tmA_GPR119_R_insulinotropic_receptor

7tmA_GPR119_R_insulinotropic_receptor: cd15104 (5 - 289)

7tmA_GPR119_R_insulinotropic_receptor

7tmA_GPR119_R_insulinotropic_receptor: cd15104 (6 - 31)

7tmA_GPR119_R_insulinotropic_receptor

7tmA_GPR119_R_insulinotropic_receptor: cd15104 (39 - 65)

7tmA_GPR119_R_insulinotropic_receptor

7tmA_GPR119_R_insulinotropic_receptor: cd15104 (77 - 107)

7tmA_GPR119_R_insulinotropic_receptor

7tmA_GPR119_R_insulinotropic_receptor: cd15104 (119 - 139)

7tmA_GPR119_R_insulinotropic_receptor

7tmA_GPR119_R_insulinotropic_receptor: cd15104 (161 - 190)

7tmA_GPR119_R_insulinotropic_receptor

7tmA_GPR119_R_insulinotropic_receptor: cd15104 (217 - 247)

7tmA_GPR119_R_insulinotropic_receptor

7tmA_GPR119_R_insulinotropic_receptor: cd15104 (257 - 282)

KLF18_N

KLF18_N: cl40479 (345 - 452)

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  • 468 a.a.
Protein Preferred Names Protein Names

glucose-dependent insulinotropic receptor

Related Agents

Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-15291 MBX-2982 Agonist 98.51% Phase 2
HY-12066 GSK1292263 Agonist 99.71% Phase 2
HY-15566 APD597 Agonist 99.97% Phase 1
Pre-clinical Phase
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15565 APD668 Agonist 99.10% Unkown
HY-W011121 2-Oleoylglycerol Agonist ≥98.0% Unkown
HY-15564 AR 231453 Agonist 99.70% Unkown
HY-107535 AS1269574 Agonist 99.84% Unkown
HY-16673 PSN632408 Agonist 99.64% Unkown
HY-108258 PSN 375963 Agonist 99.96% Unkown
HY-109032 Firuglipel Agonist 99.21% Unkown
HY-146468 DPP-4/GPR119 modulator 1 Agonist / Unkown
HY-18354 GSK1104252A Activator / Unkown
HY-146469 DPP-4/GPR119 modulator 2 Agonist / Unkown
HY-108258A PSN 375963 hydrochloride Agonist / Unkown
HY-12375 BMS-903452 Agonist / Unkown
HY-113653 GSK2041706A Agonist / Unkown
HY-155553 GPR119 agonist 2 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gpr119 NCBI NCBI:139760