ACACB - acetyl-CoA carboxylase beta Gene

Also Known as ACC2; ACCB; ACCbeta; HACC275; ACACbeta; ACC-beta

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 32

About ACACB

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:109,111,189-109,268,226 (from NCBI)

This gene has 15 transcripts (splice variants), 207 orthologues and 4 paralogues. Biased expression in fat (RPKM 94.8), liver (RPKM 8.9) and 6 other tissues.

Summary

Acetyl-CoA Carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. [provided by RefSeq, Oct 2022]

ACACB Products (9)

mRNA Protein Name
NM_001093.4 NP_001084.3 acetyl-CoA carboxylase 2 isoform a precursor
NM_001412734.1 NP_001399663.1 acetyl-CoA carboxylase 2 isoform a precursor
NM_001412735.1 NP_001399664.1 acetyl-CoA carboxylase 2 isoform a precursor
NM_001412736.1 NP_001399665.1 acetyl-CoA carboxylase 2 isoform b
NM_001412737.1 NP_001399666.1 acetyl-CoA carboxylase 2 isoform c
NM_001412738.1 NP_001399667.1 acetyl-CoA carboxylase 2 isoform d
NM_001412739.1 NP_001399668.1 acetyl-CoA carboxylase 2 isoform e
NM_001412741.1 NP_001399670.1 acetyl-CoA carboxylase 2 isoform f
NM_001412742.1 NP_001399671.1 acetyl-CoA carboxylase 2 isoform g

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables acetyl-CoA carboxylase activity IDA
IDA: Inferred from direct assay
19236960 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
20457939 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16794074 GOA
Biological Process GO Annotation Evidence References Source
involved in acetyl-CoA metabolic process IDA
IDA: Inferred from direct assay
20952656 GOA
involved in protein homotetramerization IDA
IDA: Inferred from direct assay
20952656 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
10677481 GOA
located in nucleus IDA
IDA: Inferred from direct assay
10677481 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACACB Protein Structure

Biotin_carb_N

Biotin_carb_N: Biotin carboxylase, N-terminal domain (260 - 379)

CPSase_L_D2

CPSase_L_D2: Carbamoyl-phosphate synthase L chain, ATP binding domain (431 - 614)

Biotin_carb_C

Biotin_carb_C: Biotin carboxylase C-terminal domain (651 - 757)

Biotin_lipoyl

Biotin_lipoyl: Biotin-requiring enzyme (897 - 961)

ACC_central

ACC_central: Acetyl-CoA carboxylase, central region (962 - 1688)

Carboxyl_trans

Carboxyl_trans: Carboxyl transferase domain (1780 - 2333)

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  • 2458 a.a.
Protein Preferred Names Protein Names

acetyl-CoA carboxylase 2

  • acetyl-Coenzyme A carboxylase beta

ACACB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ACACB O00763 GSK3A Homo sapiens P49840
Anti Tag CoIP
33961781
Intra
ACACB O00763 TACC1 Homo sapiens O75410
Anti Tag CoIP
33961781
Intra
ACACB O00763 ACACA Homo sapiens Q13085
Anti Tag CoIP
33961781
Intra
ACACB O00763 HMGA1 Homo sapiens P17096
Crosslink
30021884
Intra
ACACB O00763 IDS Homo sapiens P22304
Anti Tag CoIP
33961781
Intra
ACACB O00763 GSK3B Homo sapiens P49841
Anti Tag CoIP
33961781
Intra
ACACB O00763 PRKAA1 Homo sapiens Q13131
Anti Tag CoIP
33961781
Intra
ACACB O00763 GRK7 Homo sapiens Q8WTQ7
Anti Tag CoIP
33961781
Intra
ACACB O00763 MID1IP1 Homo sapiens Q9NPA3
Anti Tag CoIP
33961781
Intra
ACACB O00763 ACACB Homo sapiens O00763
GMS
20457939
Intra
ACACB O00763 ACAA1 Homo sapiens P09110
Anti Tag CoIP
33961781
Intra
ACACB O00763 MRPL46 Homo sapiens Q9H2W6
Anti Tag CoIP
33961781
Intra
ACACB O00763 ACACB Homo sapiens O00763
Comig Non-Denat Gel
20457939
Cross: Cross-species interaction Intra: Intraspecies interaction

ACACB Antibodies

Cat. No. Product Name Application Reactivity
HY-P80528 Acetyl Coenzyme A Carboxylase Antibody (YA644) WB, IHC-F, IHC-P, ICC/IF Human
HY-P80528A Acetyl Coenzyme A Carboxylase Antibody (YA644)(PBS only) WB, IHC-F, IHC-P, ICC/IF Human
HY-P86324 Acetyl Coenzyme A Carboxylase Antibody (YA6016) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Biotin Deficiency

  • Biotin Deficiency Disease

  • B7 Deficiency

  • Biotan Vitamin Deficiency
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00122 ACACB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20357 Acacb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26866 Acacb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ACACB MGD MGI:2140940
Bos taurus ACACB VGNC VGNC:25520
Macaca mulatta ACACB VGNC VGNC:99876
Felis catus ACACB VGNC VGNC:68655
Rattus norvegicus ACACB RGD RGD:620500
Canis familiaris ACACB VGNC VGNC:37490
Others ACACB NCBI