2. Gene
  3. Dot1l - DOT1 like histone lysine methyltransferase Gene

Dot1l - DOT1 like histone lysine methyltransferase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 362831 | Gene type: protein coding

About Dot1l

Primary_assembly 7: 8,917,786-8,956,475 reverse strand.mRatBN7.2:CM026980.1

This gene has 3 transcripts (splice variants), 205 orthologues and is associated with 7 phenotypes. Biased expression in Spleen (RPKM 51.8), Adrenal (RPKM 43.4) and 9 other tissues.

Summary

Predicted to enable Histone Methyltransferase activity (H3-K79 specific). Predicted to be involved in several processes, including DNA damage checkpoint signaling; regulation of receptor signaling pathway via JAK-STAT; and subtelomeric heterochromatin assembly. Predicted to act upstream of or within with a negative effect on gene expression. Predicted to act upstream of or within histone H3-K79 methylation; positive regulation of cell population proliferation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in mixed phenotype acute leukemia. Orthologous to human DOT1L (DOT1 like histone lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Dot1l Products(1)

mRNA Protein Name
NM_001108733.2 NP_001102203.2 histone-lysine N-methyltransferase, H3 lysine-79 specific

Dot1l Protein Structure

DOT1

DOT1: pfam08123 (114 - 316)

CC_DOT1L

CC_DOT1L: cd20902 (480 - 544)

Mplasa_alph_rch

Mplasa_alph_rch: cl37461 (505 - 658)

PHA03307

PHA03307: cl33723 (783 - 1124)

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  • 1736 a.a.
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase, H3 lysine-79 specific

DOT1-like histone H3K79 methyltransferase

DOT1-like, histone H3 methyltransferase

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-15593 Pinometostat Inhibitor 99.99% Phase 2
Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15650 SGC0946 Inhibitor 99.68% Unkown
HY-135128 Dot1L-IN-5 Inhibitor 98.57% Unkown
HY-135127 Dot1L-IN-4 Inhibitor 99.60% Unkown
HY-101520A Dot1L-IN-1 TFA Inhibitor 98.56% Unkown
HY-101520 Dot1L-IN-1 Inhibitor / Unkown
HY-145813 MU1656 Inhibitor / Unkown
HY-146724 Dot1L-IN-7 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dot1l NCBI NCBI:84444