Irak1 - interleukin-1 receptor-associated kinase 1 Gene

Also Known as RGD1563841

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 363520

About Irak1

Primary_assembly X: 151,768,777-151,778,521 reverse strand.mRatBN7.2:CM026994.1

This gene has 3 transcripts (splice variants), 187 orthologues, 4 paralogues and is associated with 24 phenotypes. Biased expression in Kidney (RPKM 194.8), Adrenal (RPKM 179.6) and 9 other tissues.

Summary

Enables heat shock protein binding activity and protein kinase activity. Involved in several processes, including JNK cascade; cellular response to lipopolysaccharide; and positive regulation of smooth muscle cell proliferation. Located in membrane. Biomarker of brain ischemia and cognitive disorder. Human ortholog(s) of this gene implicated in ankylosing spondylitis; diffuse scleroderma; psoriatic arthritis; and squamous cell carcinoma. Orthologous to human IRAK1 (interleukin 1 receptor associated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Irak1 Products (1)

mRNA Protein Name
NM_001127555.1 NP_001121027.1 interleukin-1 receptor-associated kinase 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables heat shock protein binding IDA
IDA: Inferred from direct assay
23324889 RGD
enables protein kinase activity IDA
IDA: Inferred from direct assay
15793310 RGD
Biological Process GO Annotation Evidence References Source
involved in JNK cascade IMP
IMP: Inferred from mutant phenotype
15890643 RGD
involved in cellular response to heat IDA
IDA: Inferred from direct assay
23324889 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
15793310 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
15793310 RGD
involved in cytokine-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
15890643 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
15890643 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
15793310 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Irak1 Protein Structure

Death_IRAK1

Death_IRAK1: cd08794 (16 - 99)

PKc_like

PKc_like: cl21453 (218 - 521)

  • 0
  • 200
  • 400
  • 600
  • 711 a.a.
Protein Preferred Names Protein Names

interleukin-1 receptor-associated kinase 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0380 Trimebutine Inhibitor 99.42% Yes
HY-B0380A Trimebutine maleate Inhibitor 99.66% Yes

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-160487 KME-2780 Inhibitor 98.94% Phase 2
HY-153110 Larotinib Inhibitor 99.50% Phase 1

Pre-clinical Phase

Bioactive Molecules (23)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0039 Ginsenoside Rb1 Inhibitor 99.75% Unkown
HY-147141 HS-276 Inhibitor 98.93% Unkown
HY-103017A JH-X-119-01 Inhibitor 99.65% Unkown
HY-153188 JNJ-1013 Degrader 99.97% Unkown
HY-111101 AZ1495 Inhibitor 98.07% Unkown
HY-103017 JH-X-119-01 hydrochloride Inhibitor 99.14% Unkown
HY-137342 SB1-G-187 Degrader 98.70% Unkown
HY-134911 HS-243 Inhibitor 99.95% Unkown
HY-159953 IRAK1/4/pan-FLT3 Kinase-IN-1 Inhibitor 99.25% Unkown
HY-153224 GLPG2534 Inhibitor 98.73% Unkown
HY-153110A Larotinib mesylate hydrate Inhibitor 98.66% Unkown
HY-177515 IRAK4 modulator-2 Inhibitor 99.86% Unkown
HY-179095 UR241-2 Inhibitor 99.68% Unkown
HY-159953A IRAK1/4/pan-FLT3 Kinase-IN-1 hydrochloride Inhibitor 98.46% Unkown
HY-N0039R Ginsenoside Rb1 (Standard) Inhibitor 99.26% Unkown
HY-147141A HS-276 hydrochloride Inhibitor / Unkown
HY-B0380S1 Trimebutine-d5 fumarate Inhibitor / Unkown
HY-181712 IRAK1-IN-2 Inhibitor / Unkown
HY-162641 AF-45 Inhibitor / Unkown
HY-B0380S2 Trimebutine-d3 hydrochloride Inhibitor / Unkown
HY-125142 AP-24567 Inhibitor / Unkown
HY-147141B HS-276 formic Inhibitor / Unkown
HY-153188A (S)-JNJ-1013 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Irak1 NCBI NCBI:3654