2. Gene
  3. H2ax - H2A.X variant histone Gene

H2ax - H2A.X variant histone Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as H2afx; RGD1566119

Gene ID: 500987 | Gene type: protein coding

About H2ax

Summary

Predicted to enable damaged DNA binding activity; Enzyme binding activity; and histone binding activity. Involved in several processes, including cellular response to gamma radiation; cellular senescence; and cerebral cortex development. Located in nucleus. Used to study hypertension; status epilepticus; and transient cerebral ischemia. Biomarker of liver benign neoplasm. Orthologous to human H2AX (H2A.X variant histone). [provided by Alliance of Genome Resources, Apr 2022]

H2ax Products(1)

mRNA Protein Name
NM_001109291.2 NP_001102761.1 H2A.X variant histone
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to gamma radiation IDA
IDA: Inferred from direct assay
17552875 RGD
involved in cellular senescence IEP
IEP: Inferred from expression pattern
19946210 RGD
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
3622934 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
3932111 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

H2A.X variant histone

H2A histone family, member X

Related Agents

Clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-12037A Rigosertib 98.52% Phase 3
HY-12037 Rigosertib sodium 99.57% Phase 3
HY-18174 Prexasertib 98.74% Phase 2
HY-18174A Prexasertib dihydrochloride 99.41% Phase 2
HY-18174E Prexasertib dimesylate 99.04% Phase 2
HY-18174B Prexasertib Mesylate Hydrate / Phase 2
HY-18174C Prexasertib mesylate / Phase 2
Pre-clinical Phase
Bioactive Molecules (16)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-117693 Mirin Inhibitor 98.12% Unkown
HY-123834 FEN1-IN-1 99.50% Unkown
HY-101089 RHPS4 99.88% Unkown
HY-122181B OTS186935 hydrochloride Inhibitor 99.22% Unkown
HY-N0316 Mollugin 99.48% Unkown
HY-103241 Ro 90-7501 99.10% Unkown
HY-122182 OTS193320 98.64% Unkown
HY-122181 OTS186935 Inhibitor 98.55% Unkown
HY-RS05957 H2AX Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-122181A OTS186935 trihydrochloride Inhibitor / Unkown
HY-117688 WJ35435 / Unkown
HY-121777 SFOM-0046 Inhibitor / Unkown
HY-145288 Antitumor agent-36 / Unkown
HY-145289 Antitumor agent-37 / Unkown
HY-162985 JHD205 Inhibitor / Unkown
HY-18174H Prexasertib lactate / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens H2ax NCBI NCBI:3014