H2ax - H2A.X variant histone Gene

Also Known as H2afx; RGD1566119

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 500987

Summary

Predicted to enable damaged DNA binding activity; enzyme binding activity; and histone binding activity. Involved in several processes, including cellular response to gamma radiation; cellular senescence; and cerebral cortex development. Located in nucleus. Used to study hypertension; status epilepticus; and transient cerebral ischemia. Biomarker of liver benign neoplasm. Orthologous to human H2AX (H2A.X variant histone). [provided by Alliance of Genome Resources, Apr 2022]

H2ax Products (1)

mRNA Protein Name
NM_001109291.2 NP_001102761.1 H2A.X variant histone

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cellular response to gamma radiation IDA
IDA: Inferred from direct assay
17552875 RGD
involved in cellular senescence IEP
IEP: Inferred from expression pattern
19946210 RGD
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
3622934 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
3932111 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

H2A.X variant histone

  • H2A histone family, member X

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-113041 Prostaglandin A2 99.9% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-12037 Rigosertib sodium 99.57% Phase 3
HY-18174H Prexasertib lactate / Phase 2

Pre-clinical Phase

Bioactive Molecules (39)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18174 Prexasertib 99.64% Unkown
HY-117693 (E/Z)-Mirin Inhibitor 99.22% Unkown
HY-123834 FEN1-IN-1 99.85% Unkown
HY-12037A Rigosertib 99.01% Unkown
HY-101089 RHPS4 99.88% Unkown
HY-122181 OTS186935 Inhibitor 99.69% Unkown
HY-18174A Prexasertib dihydrochloride 99.73% Unkown
HY-158975 VRK1/CK1-IN-1 Inhibitor 98.69% Unkown
HY-122181B OTS186935 hydrochloride Inhibitor 99.58% Unkown
HY-W1126504 ETN029 Ligand 99.91% Unkown
HY-18174E Prexasertib dimesylate 98.90% Unkown
HY-N0316 Mollugin 99.79% Unkown
HY-103241 Ro 90-7501 98.50% Unkown
HY-163944 LL-K12-18 98.42% Unkown
HY-122182 OTS193320 99.11% Unkown
HY-N2445 Flavokawain C 99.79% Unkown
HY-181557 SY-589 98.50% Unkown
HY-18174B Prexasertib Mesylate Hydrate / Unkown
HY-RS05957 H2AX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-18174C Prexasertib mesylate / Unkown
HY-122181A OTS186935 trihydrochloride Inhibitor / Unkown
HY-117688 WJ35435 / Unkown
HY-121777 SFOM-0046 Inhibitor / Unkown
HY-122860 SKLB-C05 / Unkown
HY-132972 TrxR-IN-2 / Unkown
HY-145288 Antitumor agent-36 / Unkown
HY-145289 Antitumor agent-37 / Unkown
HY-162985 JHD205 Inhibitor / Unkown
HY-167237 Calactin / Unkown
HY-168877 FMP Activator / Unkown
HY-174989 ATM-IN-2 / Unkown
HY-175700 YCJ-02 / Unkown
HY-181018 Topo I/DDX5-IN-1 / Unkown
HY-181678 DNA-PK/HDAC6-IN-1 / Unkown
HY-183330 Topo I/II-IN-3 / Unkown
HY-184416 GDD-261 / Unkown
HY-W414334 ICR-191 dihydrochloride Activator ≥95.0% Unkown
HY-RS16644 H2ax Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23078 H2ax Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens H2ax NCBI NCBI:3014