ANGPTL4 - angiopoietin like 4 Gene

Also Known as NL2; ARP4; FIAF; HARP; PGAR; HFARP; TGQTL; UNQ171; pp1158

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51129

About ANGPTL4

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:8,364,155-8,374,370 (from NCBI)

This gene has 11 transcripts (splice variants), 240 orthologues, 25 paralogues and is associated with 1 phenotype. Broad expression in liver (RPKM 42.4), fat (RPKM 23.7) and 17 other tissues.

Summary

This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and Insulin sensitivity. This protein can also act as an Apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013]

ANGPTL4 Products (2)

mRNA Protein Name
NM_001039667.3 NP_001034756.1 angiopoietin-related protein 4 isoform b precursor
NM_139314.3 NP_647475.1 angiopoietin-related protein 4 isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
19028676 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21397862 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
10698685 GOA
involved in negative regulation of lipoprotein lipase activity IDA
IDA: Inferred from direct assay
19542565 GOA
involved in protein unfolding IDA
IDA: Inferred from direct assay
29899144 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
10698685 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
10698685 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANGPTL4 Protein Structure

Fibrinogen_C

Fibrinogen_C: Fibrinogen beta and gamma chains, C-terminal globular domain (185 - 399)

  • 0
  • 100
  • 200
  • 300
  • 406 a.a.
Protein Preferred Names Protein Names

angiopoietin-related protein 4

  • PPARG angiopoietin related protein

ANGPTL4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ANGPTL4 Q9BY76 ITGB5 Homo sapiens P18084
Anti Bait CoIP
21397862
Intra
ANGPTL4 Q9BY76 NMT2 Homo sapiens O60551
Anti Tag CoIP
33961781
Intra
ANGPTL4 Q9BY76 LPL Homo sapiens P06858
ELISA
19318355
Intra
ANGPTL4 Q9BY76 ANGPTL4 Homo sapiens Q9BY76
GMS
19028676
Intra
ANGPTL4 Q9BY76 PM20D2 Homo sapiens Q8IYS1
Anti Tag CoIP
33961781
Intra
ANGPTL4 Q9BY76 AASDHPPT Homo sapiens Q9NRN7
Anti Tag CoIP
33961781
Intra
ANGPTL4 Q9BY76 PM20D2 Homo sapiens Q8IYS1
Anti Tag CoIP
28514442
Intra
ANGPTL4 Q9BY76 AASDHPPT Homo sapiens Q9NRN7
Anti Tag CoIP
28514442
Intra
ANGPTL4 Q9BY76 ITGB1 Homo sapiens P05556
PLA
21397862
Intra
ANGPTL4 Q9BY76 NMT2 Homo sapiens O60551
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ANGPTL4 Proteins

Cat. No. Product Name Accession Purity
HY-P7507 ANGPTL4/Angiopoietin-related 4 Protein, Human (HEK293, His) Q9BY76-1(P166-S406) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700562 ANGPTL4/Angiopoietin-related 4 Protein, Human (GST) Q9BY76-1 (V28-E403) ≥ 90%, as determined by reducing SDS-PAGE.

ANGPTL4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82345 Angiopoietin Like 4 Antibody (YA2090) WB, ICC/IF, FC Human
HY-P82345A Angiopoietin Like 4 Antibody (YA2090)(PBS only) WB, ICC/IF, FC Human

Related Diseases

Diseases Alias
Plasma Triglyceride Level Quantitative Trait Locus

  • TGQTL

  • Plasma Triglyceride Level Qtl, Low
Gastric Antral Vascular Ectasia

  • Watermelon Stomach

  • Gave
Familial Hyperlipidemia

  • Familial Hyperlipoproteinemia

  • Hyperlipidaemia

  • Hyperlipoproteinemias

  • Hyperlipidemia

  • Hyperlipemia

  • Hyperlipidemias
Endometrial Clear Cell Adenocarcinoma

  • Clear Cell Carcinoma Of Endometrium
Hyperlipoproteinemia, Type I

  • Lipoprotein Lipase Deficiency

  • Familial Chylomicronemia Syndrome

  • Lpl Deficiency

  • Hyperchylomicronemia, Familial

  • Hyperlipemia, Idiopathic, Burger-Grutz Type

  • Hyperlipemia, Essential Familial

  • Lipase D Deficiency

  • Lipd Deficiency

  • Hyperlipoproteinemia, Type Ia

  • Chylomicronemia, Familial

  • High Density Lipoprotein Cholesterol Level Qtl 11

  • Hyperlipoproteinemia Type 1

  • Hyperlipoproteinemia 1

  • HLPP1

  • Lipoprotein Lipase

  • Hyperlipoproteinemia Type I

  • Familial Hyperchylomicronemia Syndrome
Mesenteric Lymphadenitis

  • Mesenteric Adenitis
Hypobetalipoproteinemia, Familial, 2

  • Familial Hypobetalipoproteinemia 2

  • FHBL2

  • Hypolipidemia, Familial, Combined

  • Combined Familial Hypolipidemia

  • Combined Hypobetalipoproteinemia Familial

  • Hypobetalipoproteinemia, Familial, Type 2
Familial Lipoprotein Lipase Deficiency

  • Familial Lpl Deficiency

  • Familial Hyperchylomicronemia

  • Hyperlipoproteinemia Type I

  • Familial Hyperlipoproteinemia Type I

  • Hyperchylomicronemia

  • Burger-Grutz Syndrome

  • Endogenous Hypertriglyceridaemia

  • Familial Fat-Induced Hypertriglyceridemia

  • Lipd Deficiency

  • Lpl Deficiency

  • Lipase D Deficiency

  • Lipoprotein Lipase Deficiency, Familial

  • Familial Chylomicronemia Syndrome

  • Fredrickson Type I Hyperlipoproteinemia

  • Fredrickson Type I Lipaemia

  • Hypercholesterinaemic Xanthomatosis

  • Mixed Hyperglyceridemia

  • Lipoprotein Lipase Deficiency

  • Type I Hyperlipoproteinemia

  • Hyperlipoproteinemia Type Ia

  • Familial Hyperlipo-Proteinemia Type 1
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Nephrotic Syndrome

  • Finnish Congenital Nephrotic Syndrome

  • Ns - [Nephrotic Syndrome]

  • Nephrosis Syndrome

  • Nephrosis Nos

  • Glomerular Lesion Nephrosis
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diabetes Mellitus

  • Diabetes
Heart Disease

  • Heart Failure

  • Congenital Heart Disease

  • Heart Diseases

  • Congenital Heart Defects

  • Congenital Heart Defect

  • Heart Malformation

  • Congenital Anomaly Of Heart

  • Heart Defect

  • Heart-Congenital Defect

  • Congenital Heart Disorder

  • Heart Defects Congenital

  • Heart Defects, Congenital

  • Heart Defects

  • Heart Disease, Congenital

  • Disease, Heart, Congenital

  • Congestive Heart Failure
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-103325 JTE-907 Activator 98.54% Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990335 Anti-ANGPTL4 Antibody Inhibitor 97.18% Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ANGPTL4 VGNC VGNC:37860
Mus musculus ANGPTL4 MGD MGI:1888999
Rattus norvegicus ANGPTL4 RGD RGD:735058
Felis catus ANGPTL4 VGNC VGNC:59780
Bos taurus ANGPTL4 VGNC VGNC:25893
Macaca mulatta ANGPTL4 VGNC VGNC:108464
Others ANGPTL4 NCBI