SLC15A3 - solute carrier family 15 member 3 Gene

Also Known as OCTP; PHT2; PTR3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51296

About SLC15A3

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:60,937,084-60,952,176 (from NCBI)

This gene has 14 transcripts (splice variants), 121 orthologues and 4 paralogues. Broad expression in spleen (RPKM 20.2), lung (RPKM 17.9) and 23 other tissues.

Summary

Enables dipeptide transmembrane transporter activity. Involved in dipeptide import across plasma membrane. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]

SLC15A3 Products (1)

mRNA Protein Name
NM_016582.3 NP_057666.1 solute carrier family 15 member 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables dipeptide transmembrane transporter activity IDA
IDA: Inferred from direct assay
31073693 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24695226 GOA
Biological Process GO Annotation Evidence References Source
involved in dipeptide import across plasma membrane IDA
IDA: Inferred from direct assay
31073693 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC15A3 Protein Structure

PTR2

PTR2: POT family (101 - 500)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 581 a.a.
Protein Preferred Names Protein Names

solute carrier family 15 member 3

  • osteoclast transporter

SLC15A3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SLC15A3 Q8IY34 KRTAP12-2 Homo sapiens P59991
MAPPIT
32296183
Intra
SLC15A3 Q8IY34 KRTAP12-2 Homo sapiens P59991
Y2H Prey Pooling
32296183
Intra
SLC15A3 Q8IY34 KRTAP9-8 Homo sapiens Q9BYQ0
Validated Y2H
32296183
Intra
SLC15A3 Q8IY34 KRTAP9-8 Homo sapiens Q9BYQ0
Y2H Array
32296183
Intra
SLC15A3 Q8IY34 KRTAP9-8 Homo sapiens Q9BYQ0
Y2H Prey Pooling
32296183
Intra
SLC15A3 Q8IY34 KRTAP19-2 Homo sapiens Q3LHN2
Y2H Prey Pooling
32296183
Intra
SLC15A3 Q8IY34 KRTAP19-2 Homo sapiens Q3LHN2
Y2H Array
32296183
Intra
SLC15A3 Q8IY34 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
32296183
Intra
SLC15A3 Q8IY34 KRTAP5-9 Homo sapiens P26371
Y2H Array
32296183
Intra
SLC15A3 Q8IY34 SLC15A4 Homo sapiens Q8N697
Anti Tag CoIP
24695226
Intra
SLC15A3 Q8IY34 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
SLC15A3 Q8IY34 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
SLC15A3 Q8IY34 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
SLC15A3 Q8IY34 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
Intra
SLC15A3 Q8IY34 HOXA1 Homo sapiens P49639
Y2H Array
32296183
Intra
SLC15A3 Q8IY34 NOD2 Homo sapiens Q9HC29
Anti Tag CoIP
24695226
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypotrichosis 4

  • HYPT4

  • Marie Unna Hereditary Hypotrichosis 1

  • Muhh1

  • Hypotrichosis, Marie Unna Type, 1

  • Hypotrichosis Marie Unna 1

  • Marie Unna Hereditary Hypotrichosis Type 1

  • Hypotrichosis, Hereditary, Marie Unna Type, 1

  • Hypotrichosis, Type 4
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13014 SLC15A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SLC15A3 RGD RGD:628663
Macaca mulatta SLC15A3 VGNC VGNC:77504
Canis familiaris SLC15A3 VGNC VGNC:52046
Bos taurus SLC15A3 VGNC VGNC:34680
Felis catus SLC15A3 VGNC VGNC:65202
Mus musculus SLC15A3 MGD MGI:1929691
Others SLC15A3 NCBI