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Flt1 - Fms related receptor tyrosine kinase 1 Gene

Also Known as FLT-1; VEGFR-1

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 54251

About Flt1

Primary_assembly 12: 7,297,292-7,468,626 forward strand.mRatBN7.2:CM026985.1

This gene has 1 transcript (splice variant), 199 orthologues, 54 paralogues and is associated with 65 phenotypes. Biased expression in Lung (RPKM 293.4), Heart (RPKM 182.9) and 8 other tissues.

Summary

Enables ATP binding activity; growth factor binding activity; and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including liver regeneration; negative regulation of vascular endothelial growth factor production; and positive regulation of cell population proliferation. Located in extracellular space and plasma membrane. Used to study corneal neovascularization. Biomarker of breast cancer; diabetic retinopathy; liver cirrhosis; myocardial infarction; and vascular dementia. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; diabetic retinopathy; and pre-eclampsia. Orthologous to human FLT1 (fms related receptor tyrosine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Flt1 Products (2)

mRNA	Protein	Name
NM_001309381.1	NP_001296310.1	vascular endothelial growth factor receptor 1 isoform 2 precursor
NM_019306.2	NP_062179.2	vascular endothelial growth factor receptor 1 isoform 1 precursor

Flt1 Protein Structure

Ig_3

IG_like

I-set

PKc_like

0
300
600
900
1200
1336 a.a.

Protein Preferred Names	Protein Names
vascular endothelial growth factor receptor 1	FMS-like tyrosine kinase 1 Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) tyrosine-protein kinase receptor FLT vascular endothelial growth factor receptor 1-like vascular endothelial growth factor/vascular permeability factor receptor

Recombinant Flt1 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P73552	VEGFR-1 Protein, Rat (HEK293, His)	P53767 (Y23-E758)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (6)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-50751	Linifanib		99.39%	Phase 3
HY-10205	Cediranib		99.87%	Phase 3
HY-10517	Orantinib		99.29%	Phase 3
HY-100315	XL 999	Inhibitor	99.01%	Phase 2
HY-50703	MK-2461	Inhibitor	99.28%	Phase 2
HY-10204	OSI-930		98.33%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-P991430	RO5323441	Inhibitor	95.85%	Phase 1

Pre-clinical Phase

Bioactive Molecules (20)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-15813	FIIN-1	Inhibitor	99.04%	Unkown
HY-P10831	GNQWFI	Antagonist	99.82%	Unkown
HY-108551	MG-262		95.0%	Unkown
HY-13049	Cediranib maleate		99.68%	Yes
HY-145293	TNIK-IN-3	Inhibitor	99.79%	Unkown
HY-P5438	Srctide	Substrate	99.71%	Unkown
HY-101219	VEGFR-IN-1	Inhibitor	99.07%	Unkown
HY-50751G	Linifanib (GMP)	Inhibitor	/	Unkown
HY-110272	Vatalanib succinate	Inhibitor	/	Unkown
HY-123586	L-783277	Inhibitor	/	Unkown
HY-168114	Multi-kinase inhibitor 3	Inhibitor	/	Unkown
HY-168115	Multi-kinase inhibitor 4	Inhibitor	/	Unkown
HY-181754	TPKI-39	Inhibitor	/	Unkown
HY-182354	VEGFR2-IN-84	Inhibitor	/	Unkown
HY-18692	Multi-kinase-IN-12	Inhibitor	/	Unkown
HY-NP223	PLGF-2 Protein, human		/	Unkown
HY-RS04987	FLT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04988	Flt1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04989	Flt1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174684	Human FLT1 mRNA		/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P99364	Icrucumab		99.9%	Unkown
HY-P990541	Anti-VEGFR1/FLT1 Antibody	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Flt1	NCBI	NCBI:2321