Flt1 - Fms related receptor tyrosine kinase 1 Gene

Rattus norvegicus

Also known as FLT-1; VEGFR-1

Gene ID: 54251 | Gene type: protein coding

About Flt1

Primary_assembly 12: 7,297,292-7,468,626 forward strand.mRatBN7.2:CM026985.1

This gene has 1 transcript (splice variant), 199 orthologues, 54 paralogues and is associated with 65 phenotypes. Biased expression in Lung (RPKM 293.4), Heart (RPKM 182.9) and 8 other tissues.

Summary

Enables ATP binding activity; growth factor binding activity; and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including liver regeneration; negative regulation of vascular endothelial growth factor production; and positive regulation of cell population proliferation. Located in extracellular space and plasma membrane. Used to study corneal neovascularization. Biomarker of breast cancer; diabetic retinopathy; liver cirrhosis; myocardial infarction; and vascular dementia. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; diabetic retinopathy; and pre-eclampsia. Orthologous to human FLT1 (fms related receptor tyrosine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Flt1 Products(2)

mRNA	Protein	Name
NM_001309381.1	NP_001296310.1	vascular endothelial growth factor receptor 1 isoform 2 precursor
NM_019306.2	NP_062179.2	vascular endothelial growth factor receptor 1 isoform 1 precursor

Flt1 Protein Structure

Ig_3

IG_like

I-set

PKc_like

0
300
600
900
1200
1336 a.a.

Protein Preferred Names

Protein Names

vascular endothelial growth factor receptor 1

FMS-like tyrosine kinase 1	Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
tyrosine-protein kinase receptor FLT	vascular endothelial growth factor receptor 1-like
vascular endothelial growth factor/vascular permeability factor receptor

Recombinant Flt1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73552	VEGFR-1 Protein, Rat (HEK293, His)	P53767 (Y23-E758)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-50751	Linifanib		99.28%	Phase 3
HY-10205	Cediranib		99.58%	Phase 3
HY-10517	Orantinib		99.21%	Phase 3
HY-13049	Cediranib maleate		99.95%	Phase 3
HY-50751G	Linifanib (GMP)	Inhibitor	/	Phase 3
HY-10204	OSI-930		98.57%	Phase 1

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99830	Conbercept		/	Phase 4
HY-P99364	Icrucumab	Inhibitor	95.00%	Phase 2

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100315	Tyrosine kinase-IN-1	Inhibitor	99.34%	Unkown
HY-145293	TNIK-IN-3	Inhibitor	99.88%	Unkown
HY-101219	VEGFR-IN-1		98.42%	Unkown
HY-15813	FIIN-1	Inhibitor	99.11%	Unkown
HY-110272	Vatalanib succinate	Inhibitor	/	Unkown
HY-RS04987	FLT1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS04988	Flt1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS04989	Flt1 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Flt1	NCBI	NCBI:2321
Mus musculus	Flt1	NCBI	NCBI:14254

Name
Email *

	Sorry, but the email address you supplied was invalid.